Ca2+-activated potassium (KCa) channel inhibition decreases neuronal activity-blood flow coupling

Brain Research

Volumn 948, Issue 1-2, 2002, Pages 108-116

  Gerrits, Ronald J ^a,b   Stein, Elliot A ^a   Greene, Andrew S ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b MILWAUKEE SCHOOL OF ENGINEERING   (United States)

Author keywords

Cerebrovascular circulation; Functional coupling; Functional hyperemia; Whisker barrel cortex

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; IBERIOTOXIN; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BRAIN METABOLISM; CONTROLLED STUDY; ELECTRIC ACTIVITY; EVOKED RESPONSE; LASER DOPPLER FLOWMETRY; MALE; NERVE CELL; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT; RODENT; SKULL; SOMATOSENSORY CORTEX; TEMPORAL LOBE; VIBRISSA;

ANIMALS; BLOOD FLOW VELOCITY; BLOOD GAS ANALYSIS; CEREBROVASCULAR CIRCULATION; DRUG ADMINISTRATION ROUTES; LASER-DOPPLER FLOWMETRY; MALE; MEMBRANE POTENTIALS; NEURONS; PEPTIDES; PERFUSION; PHYSICAL STIMULATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RATS, SPRAGUE-DAWLEY; SOMATOSENSORY CORTEX; SYNAPTIC TRANSMISSION; TETRAETHYLAMMONIUM; VIBRISSAE;

EID: 0037032095     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02957-8     Document Type: Article

References (49)

1. K. Adachi, S. Takahashi, P. Melzer, K L. Campos, T. Nelson, C. Kennedy, L. Sokoloff, Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. Am. J. Physiol. 267 (6 Part 2) (Heart Circ. Physiol. 36) (1994) H2155-H2162.
2. Alkayed N.J., Birks E.K., Narayanan J., Petrie K.A., Kohler-Cabot A.E., Harder D.R. Role of p-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. Stroke. 28:1997;1066-1072.
3. Alkayed N.J., Birks E.K., Hudetz A.G., Roman R.J., Henderson L., Harder D.R. Inhibition of brain p-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow. Am. J. Physiol. 271:(Heart Circ. Physiol. 40):1996;H1541-H1546.
4. + channel by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. 91:1994;7583-7587.
5. + channels and cAMP in opioid-induced pial artery dilation. Brain Res. 747:1997;252-258.
6. + channels regulate the myogenic tone in the resting state of arteries from spontaneously hypertensive rats. Br. J. Pharmacol. 108:1993;214-222.
7. Ayata C., Ma J., Meng W., Huang P., Moskowitz M.A. L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice. J. Cereb. Blood Flow Metab. 16:1996;539-541.
8. + current in rat saphenous artery. Hypertension Dallas. 19:1992;725-729.
9. Bhardwaj A., Northington F.J., Carhuapoma J.R., Falck J.R., Harder D.R., Traytsman R.J., Koehler R.C. P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. Am. J. Physiol. 279:2000;H1616-H1624.
10. Brayden J.E., Nelson M.T. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science. 256:1992;532-535.
11. Budavari S., Merck Index. 12th Edition No. 9341. 1996;Merck.
12. Cholet N., Seylaz J., Lacombe P., Bonvento G. Local uncoupling of the cerebrovascular and metabolic responses to somatosensory stimulation after neuronal nitric oxide synthase inhibition. J. Cereb. Blood Flow Metab. 17:(11):1997;1191-1201.
13. Di S., Barth D.S. Topographic analysis of field potentials in rat vibrissa/barrel cortex. Brain Res. 546:1991;106-112.
14. Di S., Baumgartner C., Barth D.S. Laminar analysis of extracellular field potentials in rat vibrissa/barrel cortex. J. Neurophys. 63:(4):1990;832-840.
15. Dirnagl U., Kaplan B., Jacewicz M., Pulsinelli W. Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model. J. Cereb. Blood Flow Metab. 9:1989;589-596.
16. Dirnagl U., Lindauer U., Villringer A. Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats. Neurosci. Lett. 149:1993;43-46.
17. Faraci F.M., Breese K.R., Heistad D.D. Cerebral vasodilation during hypercapnia: role of glibenclamide-sensitive potassium channels and nitric oxide. Stroke. 25:(8):1994;1679-1683.
18. Faraci F.M., Heistad D.D. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol. Rev. 78:(1):1998;53-97.
19. Gerrits R.J., Stein E.A., Greene A.S. Blood flow increases linearly in rat somatosensory cortex with increased whisker movement frequency. Brain Res. 783:1998;151-157.
20. Gerrits R.J., Stein E.A., Greene A.S. Laser-Doppler flowmetry utilizing a thinned skull cranial window preparation and automated stimulation. Brain Res. Prot. 3:1998;14-21.
21. Gerrits R.J., Stein E.A., Greene A.S. Anesthesia alters NO-mediated functional hyperemia. Brain Res. 907:2001;20-26.
22. Harder D.R., Alkayed N.J., Lange A.R., Gebremedhin D., Roman R.J. Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites. Stroke. 29:(1):1998;229-234.
23. Ca channel activator, NS1619, on rat cerebral artery smooth muscle. Br. J. Pharmacol. 117:1996;119-129.
24. Hong K.W., Yoo S., Yu S.S., Lee J.Y., Rhim B.Y. Pharmacological coupling and functional role CGRP receptors in the vasodilation of rat pial arterioles. Am. J. Physiol. 270:1996;H317-H323.
25. Irikura K., Maynard K.I., Moskowitz M.A. Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-Nitroarginine during vibrissal stimulation. J. Cereb. Blood Flow Metab. 14:1994;45-48.
26. Kuschinsky W., Wahl M. Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol. Rev. 58:(3):1978;656-689.
27. Lang M.G., Paterno R., Faraci F.M., Heistad D.D. Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles. Stroke. 28:1997;181-185.
28. Lindauer U., Villringer A., Dirnagl U. Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics. Am. J. Physiol. 264:(Heart Circ. Physiol. 33):1993;H1223-H1228.
29. Matsuura T., Fujita H., Kashikura K., Kanno I. Evoked local cerebral blood flow induced by somatosensory stimulation is proportional to the baseline flow. Neurol. Res. 38:(4):2000;341-348.
30. Nelson M.T., Quayle J.M. Physiological roles and properties of potassium channels in arterial smooth muscle. Trends Cardiovasc. Med. 3:1993;54-60.
31. Nguyen T.S., Winn H.R., Janigro D. ATP-sensitive potassium channels may participate in the coupling of neuronal activity and cerebrovascular tone. Am J. Physiol. 278:(3):2000;H878-H885.
32. Oh Y. Ion channels in neuroglial cells. Kaohsiung J. Med. Sci. 13:1997;1-9.
33. + channels in cerebral vasodilatation induced by increases in cyclic GMP and cyclic AMP in the rat. Stroke. 27:(9):1996;1603-1608.
34. Paterno R., Heistad D.D., Faraci F. Potassium channels modulate cerebral autoregulation during acute hypertension. Am J. Physiol. 278:(Heart Circ. Physiol):2000;H2003-H2007.
35. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1998;Academic Press, San Diego, CA.
36. Pearce W.J., Harder D.R. Cerebrovascular smooth muscle and endothelium. Mraovitch S., Sercombe R., Neurophysiological Basis of Cerebral Blood Flow Control: An Introduction. 1996;145-175 John Libby, London.
37. Reid J.M., Paterson D.J., Ashcroft F.M., Bergel D.H. The effect of tolbutamide on cerebral blood flow during hypoxia and hypercapnia in the anesthetized rat. Pflugers Arch. 425:1993;362-364.
38. ATP ion channel link in the inhibition of hypercapnic dilation of pial arterioles by 7-nitroindazole and tetrodotoxin. Eur. J. Pharm. 417:2001;203-215.
39. Roy C.W., Sherrington C.S. On the regulation of the blood supply of the brain. J. Physiol. 11:1890;85-108.
40. + currents in neurones: types, physiological roles and modulation. Trends Neurosci. 19:1996;150-154.
41. + channels in smooth muscle cells from basilar artery of guinea pig. Pflugers Arch. 430:1995;984-993.
42. + channels. Circ. Res. 76:1995;1057-1062.
43. Tomiyama Y., Brian J.E., Todd M.M. Cerebral blood flow during hemodilution and hypoxia in rats: role of ATP-sensitive potassium channels. Stroke. 30:(9):1999;1942-1947.
44. Villringer A., Dirnagl U. Coupling of brain activity and cerebral blood flow. Cereb. Brain Metab. Rev. 7:(3):1995;240-276.
45. Wang Q., Bryan R.M., Pelligrino D.A. Calcium-dependent and ATP-sensitive potassium channels and the 'permissive' function of cyclic GMP in hypercapnia-induced pial arteriolar relaxation. Brain Res. 793:1998;187-196.
46. Wang Q., Kjaer T., Jorgensen M.B., Paulson O.B., Lassen N.A., Diemer N.H., Lou H.C. Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats. Neurol. Res. 15:(1):1993;33-36.
47. Wei E.P., Kontos H.A. Blockade of ATP-sensitive potassium channels in cerebral arterioles inhibits vasoconstriction from hypocapnic alkalosis in cats. Stroke. 30:(4):1999;851-853.
48. Wei E.P., Kontos H.A., Beckman J.S. Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. Am. J. Physiol. 271:(Heart Circ. Physiol. 40):1996;H1262-H1266.
49. 1 receptors in C6 glial cells are coupled to calcium-dependent potassium channels via release of calcium from internal stores. Naunyn-Schmiedeberg's Arch. Pharmacol. 355:1997;559-565.