Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2432-2453

  Danilewicz, John C ^a   Abel, Stuart M ^a   Brown, Alan D ^a   Fish, Paul V ^a   Hawkeswood, Edward ^a   Holland, Stephen J ^a   James, Keith ^a   McElroy, Andrew B ^a   Overington, John ^a   Powling, Michael J ^a   Rance, David J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGATROBAN; BENZAMIDINE; PHENYLALANYLPROLYLARGININE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; CATALYSIS; COVALENT BOND; DRUG DESIGN; GASTROINTESTINAL ABSORPTION; HEMOSTASIS; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR INTERACTION; THROMBOCYTE AGGREGATION;

ANIMALS; ANTICOAGULANTS; BIOLOGICAL AVAILABILITY; CATTLE; DOGS; HUMANS; MALE; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0037030654     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011133d     Document Type: Article

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