Disulfide-bond formation in the transthyretin mutant Y114C prevents amyloid fibril formation in vivo and in vitro

Biochemistry

Volumn 41, Issue 44, 2002, Pages 13143-13151

  Eneqvist, Therese ^a,b   Olofsson, Anders ^a   Ando, Yukio ^c   Miyakawa, Taihei ^c   Katsuragi, Shoichi ^c   Jass, Jana ^a   Lundgren, Erik ^a   Sauer Eriksson, A Elisabeth ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANTS;

ANTIBODIES; CHEMICAL BONDS; DISEASES; X RAY CRYSTALLOGRAPHY;

BIOCHEMISTRY;

AMYLOID; DNA; MUTANT PROTEIN; PLASMA PROTEIN; PREALBUMIN;

ADULT; AMYLOID NEUROPATHY; AMYLOIDOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; CASE REPORT; CRYSTALLIZATION; DISULFIDE BOND; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILIAL AMYLOID POLYNEUROPATHY; FAMILIAL DISEASE; FEMALE; GEL ELECTROPHORESIS; GENE MUTATION; HUMAN; HUMAN TISSUE; NEUROPATHY; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; VITREOUS BODY; X RAY CRYSTALLOGRAPHY;

ADULT; AMINO ACID SUBSTITUTION; AMYLOID; AMYLOID NEUROPATHIES, FAMILIAL; ANTIBODIES, MONOCLONAL; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISULFIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPES; FEMALE; HUMANS; MIDDLE AGED; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; PREALBUMIN; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TYROSINE;

EID: 0037027338     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi025800w     Document Type: Article

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