p16INK4A and p14ARF tumour suppressors in melanoma: Lessons from the mouse

Lancet

Volumn 359, Issue 9300, 2002, Pages 7-8

  Walker, Graeme J ^a   Hayward, Nicholas K ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; DIMETHYLBENZ[A]ANTHRACENE; MONOPHENOL MONOOXYGENASE; PROTEIN; PROTEIN P14ARF; PROTEIN P16INK4A; UNCLASSIFIED DRUG;

CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHROMOSOME 9P; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; MELANOCYTE; MELANOMA; NONHUMAN; NOTE; PHOSPHORYLATION; PRIORITY JOURNAL; PROGENY; PROTEIN BINDING; PROTEIN DEGRADATION; RETINOBLASTOMA; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSGENE; TUMOR SUPPRESSOR GENE;

EID: 0037021981     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)07271-9     Document Type: Note

References (15)

1. The genetics of cutaneous melanoma
2. Germline mutations of the p16 binding domain of CDK4 in familial melanoma
3. Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France
4. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
5. A melanoma-associated germline mutation in exon 1b inactivates p14ARF
6. Role of INK4a locus in tumour suppression and cell mortality
7. Tumour suppression at the mouse INK4a locus mediated by the alternate reading frame product p19ARF
8. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
9. Essential role for oncogenic Ras in tumour maintenance
10. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
11. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
12. Dual inactivation of RB and p53 pathways in RAS-induced melanomas
13. Invasive melanoma in Cdk4-targeted mice
14. Neonatal sunburn and melanoma in mice
15. Childhood sun exposure as a risk factor for melanoma: A systematic review of epidemiologic studies