Upregulation of Kv 1.4 protein and gene expression after chronic spinal cord injury

Journal of Comparative Neurology

Volumn 443, Issue 2, 2002, Pages 154-167

  Edwards, Lori ^a   Nashmi, Raad ^a,d   Jones, Owen ^a,e   Backx, Peter ^b   Ackerley, Cameron ^c   Becker, Larry ^c   Fehlings, Michael G ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Axons; Glia; Neurotrauma; Rat; Voltage gated potassium channels

Indexed keywords

4 AMINOPYRIDINE; CALCIUM CHANNEL; GENE PRODUCT; KV 1.4 PROTEIN; MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CELL PROLIFERATION; CHANNEL GATING; CONTROLLED STUDY; DEMYELINATION; GENE CONTROL; GENE EXPRESSION; GRAY MATTER; IMMUNOBLOTTING; IMMUNOGOLD ELECTRON MICROSCOPY; IN SITU HYBRIDIZATION; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; RAT; SPINAL CORD INJURY; STEM CELL; WHITE MATTER;

ANIMALS; ASTROCYTES; AXONS; CELL DIVISION; CELL LINEAGE; FEMALE; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KV1.4 POTASSIUM CHANNEL; MICROSCOPY, ELECTRON; NERVE FIBERS, MYELINATED; NEUROFILAMENT PROTEINS; OLIGODENDROGLIA; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, WISTAR; RNA, MESSENGER; SPINAL CORD; SPINAL CORD INJURIES; STEM CELLS; UP-REGULATION;

EID: 0037016859     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.10115     Document Type: Article

References (69)

1. Cells ot the oligodendrocyte lineage proliferate following cortical stab wounds: An in vitro analysis
2. Preoligodendrocytes from adult human CNS
3. Characterization of delayed rectifier Kv channels in oligodendrocytes and progenitor cells
4. Pathology of experimental spinal cord trauma. II. Ultrastructure of axons and myelin
5. Ion channel expression by white matter glia: I. Type 2 astrocytes and oligodendrocytes
6. Ion channel expression by white matter glia: The O-2A glial progenitor cell
7. Ion channel expression by white matter glia: The type-1 astrocyte
8. Ion channel organization of the myelinated fiber
9. Axonal physiology of chronic spinal cord injury in the cat: Intracellular recording in vitro
10. Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury
11. Morphometric analysis of experimental spinal cord injury intensity to survival of myelinated axons
12. Augmentation by 4-aminopyridine of vestibulospinal free fall responses in chronic spinal-injured cats
13. NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions
14. Regulation of Kvl channel expression in oligodendrocyte progenitor cells
15. Distinct populations of identified glial cells in the developing rat spinal cord slice: Ion channel properties and cell morphology
16. Assessment of axonal dysfunction in an in vitro model of acute compressive injury to adult rat spinal cord axons
17. Changes in pharmacological sensitivity of the spinal cord to potassium channel blockers following acute spinal cord injury
18. The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury
19. + channel block
20. Nerve fibers in spinal cord impact injuries. Part 1. Changes in the myelin sheath during the initial 5 weeks
21. + Channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines
22. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family
23. 4-Aminopyridine in chronic spinal cord injury: A controlled, double-blind, crossover study of eight patients
24. 4-Aminopyridine-sensitive neurologic deficits in patients with spinal cord injury
25. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
26. + channels in activated microglia in vivo
27. Internalization of the Kvl.4 potassium channel is suppressed by clustering interactions with PSD-95
28. Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord
29. + channel expression and cell proliferation are regulated by intracellular sodium and membrane depolarization in oligodendrocyte progenitor cells
30. A Kv 1.5 to Kv 1.3 switch in endogenous hippocampal microglia and a role in proiferation
31. Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury
32. Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination
33. Proliferation of mature oligodendrocytes after trauma to the central nervous system
34. Reaction ofoligodendrocytes and astrocytes to trauma and implantation. A combined autoradiographic and immunohistochemical study
35. Can oligodendrocytes attached to myelin proliferate?
36. Loss of myelin basic protein cationicity in DM20 transgenic mice is dosage dependent
37. Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis
38. + channels in rat spinal cord
39. Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord
40. Assessment of spinal cord injury by counting corticospinal and rubrospinal neurons
41. + channels after chronic spinal cord injury
42. A simplification of the protein assay method of Lowry et al. which is more generally applicable
43. Effects of 4-aminopyridine on motor evoked potentials in patients with spinal cord injury
44. Potassium channel distribution, clustering, and function in remyelinating rat axons
45. In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination
46. Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo
47. Objective clinical assessment of motor function after experimental spinal cord injury in the rat
48. Manipulation of the delayed rectifier Kv 1.5 potassium channel in glial cells by antisense oligodeoxynucleotides
49. + and CI channels and their involvment in proliferation of rat microglial cells
50. Hetergeneous expression of voltage-gated potassuim channels of the shaker family (Kv1) in oligodendrocyte progenitors
51. Subcellular segregation of two A-type K channel proteins in rat central neurons
52. Presynaptic A-current based on heteromultimeric K channels detected in vivo
53. Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve
54. Conduction block in acute and chronic spinal cord injury: Different dose-response characteristics for reversal by 4-aminopyridine
55. FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord
56. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes
57. Identification of the delayed rectifier potassium channel, Kv 1.6, in cultured astrocytes
58. Channel expression correlates with differentiation stage during the development of oligodendrocytes from their precursor cells in culture
59. + channels
60. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain
61. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain
62. Immunohistrchemical localization of five members of the Kvl channel subunits: Contrasting subcellular locations and neruon-specific colocalizations in rat brain
63. + channels in terminal and juxtaparanodal regions of neurons
64. + channel expression in mouse mutants shiver and Trembler
65. Demyelination of spinal cord injury
66. Molecular dissection of myelinated axon
67. + currents and K channel gene expression in rat ventricle
68. Myelin gene expression after experimental contusive spinal cord injury
69. A role for glutamate and its receptors in the regulation of oligodendrocyte development in cerebellar tissue slices