Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis

Journal of Clinical Investigation

Volumn 97, Issue 2, 1996, Pages 349-358

  Mastronardi, Fabrizio G ^a   Mak, Baldwin ^a   Ackerley, Cameron A ^a   Roots, Betty I ^b   Moscarello, Mario A ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

demyelination; DM20; dysmyelination; multiple sclerosis; transgenic mice

Indexed keywords

ARGININE; CITRULLINE; MESSENGER RNA; MYELIN BASIC PROTEIN; PROTEIN ARGININE DEIMINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GENE DOSAGE; GENE EXPRESSION; IMMUNOGOLD STAINING; MULTIPLE SCLEROSIS; MYELIN SHEATH; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; TRANSGENIC MOUSE;

EID: 0030032373     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118422     Document Type: Article

References (30)

1. Moscarello, M. A , D. D. Wood, C. A. Ackerley, and C Boulias. 1994. The myelin membrane in multiple sclerosis is developmentally immature. J. Clin. Invest. 94:146-154.
2. Simons-Johnson, R. J. C. Roder, and J. R. Riordan. 1995. Over-expression of the DM-20 myelin proteolipid causes central nervous system demyelination in transgenic mice. J. Neurochem 64:967-975.
3. Mastronardi, F G., C A. Ackerley, L. Arsenault, B I. Roots, and M. A Moscarello. 1993. Demyelination in a transgenic mouse: a model for multiple sclerosis. J. Neurosci. Res. 36:315-324.
4. Chirgwin, J., A. E Przybyla, R. McDonald, and W. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
5. Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
6. Milner, R. J., and J. G. Sutcliffe. 1983. Gene expression in rat brain. Nucleic Acids Res. 11:5497-5520.
7. Fannon, A. M., and M. A. Moscarello. 1991. Characterization of myelin basic protein charge isomers from adult mouse brain. Neuroreport. 2:135-138.
8. Peterson, G. L. 1977. A simplification of the protein assay method of Lowry et al., which is more generally applicable Anal Biochem. 83:346-356
9. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227.680-685.
10. Towbin, H., T. Staehlin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application. Proc Natl. Acad. Sci. USA. 76:4350-4354.
11. Deibler, G. E., R E Martenson, and M. W. Kies. 1972. Large scale preparation of myelin basic protein from the central nervous tissue from several mammalian species. Prep. Biochem. 2:131-165.
12. Wood, D. D., and M. A. Moscarello. 1989. The isolation, characterization and lipid-aggregating properties of a citrulline containing myelin basic protein J Biol. Chem 264:5121-5127.
13. Griffith, G. 1981. Immunocytochemistry using thawed frozen sections. In The Science of Biological Specimen Preparation for Electron Microscopy and Microanalysis. J. P Revel, T. Barnord, and G H. Haggis, editors. Scanning Electron Microscopy Inc. O'Hare, IL. 153-159.
14. McLaurin, J , C. A. Ackerley. and M. A Moscarello. 1993 Localization of basic proteins in human myelin. J. Neurosci Res. 35:618-628.
15. Groome, N., A. Dawkes, R. Barry. S. Hruby, and E. Alvord, Jr. 1988. New monoclonal antibodies reactive with defined sequential epitopes in human myelin basic protein. J. Neuroimmunol. 19:305-315.
16. Weibel, E. R., G. S. Kistler, and W. F Scherle. 1966. Practical stereological methods for morphometric cytology. J. Cell Biol. 30:23-37.
17. Lamensa, J., and M. A. Moscarello. 1993. Deimination of human myelin basic protein by a peptidylarginine deiminase from bovine brain. J. Neurochem 61:987-996.
18. Deleted in proof
19. Moscarello, M. A., G. W. Brady, D. B. Fein, D. D. Wood, and T F. Cruz. 1986, The role of charge microheterogeneity of basic protein in the formation and maintainance of the multilayered structure of myelin: a possible role in multiple sclerosis. J. Neurosci. Res. 15:87-99.
20. Sorg, B. A., M. W. Smith, and A. T. Campagnoni. 1987. Developmental expression of myelin proteolipid protein and basic protein mRNA's in normal and dysmyelinating mutant mice. J. Neurochem. 49.1146-1154.
21. Fannon, A. M., F. G. Mastronardi, and M. A. Moscarello 1994. Isolation and identification of proteolipid proteins in jimpy mouse brain. Neurochem Res 19:1005-1012.
22. Fannon, A. M , and M A. Moscarello. 1990. C8 is the only MBP charge isomer in jimpy mouse brain Ann. N.Y Acad Sci. 605:379-381.
23. Fannon, A. M., and M. A. Moscarello. 1990. Myelin basic protein is affected by reduced synthesis of myelin proteolipid protein in the jimpy mouse. Biochem. J. 268:105-110.
24. Olsson, J E., J. W. Gordon, B. S. Pawlyk, D. Roof, A. Hayes, R. S. Molday, S. Mukai, G. S. Cowley, E. L. Berson, and T. P. Dryja. 1992. Transgenic mice with a rhodopsin mutation (PRO 23 HIS), a mouse model of autosomal dominant retinitis pigmentosa. Neuron 9:815-830.
25. Côté, F., J.-F. Collard, and J.-P. Julien. 1993. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotropic lateral sclerosis. Cell. 73:35-46.
26. Xu, Z., L. C. Cork, J. W. Griffin, and D. W. Cleveland. 1993. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell. 73:23-33
27. Westaway, D., S. J. De Armond, J. Cayetano-Canlas, D. Groth, D. Foster, S. L. Yang, M Torchia, G. A. Carlson. and S. B. Prusiner. 1994. Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild type prion proteins. Cell 76:117-129.
28. Prusiner, S. B , and S. J. DeArmond. 1994. Prion diseases and neurodegeneration. Ann Rev. Neurosci. 17:311-339.
29. Manetto, V., N H. Sternberger, G. Perry, L. A. Sternberger, and P Gambetti. 1988. Phosphorylation of neurofilaments is altered in amyotropic lateral sclerosis. J. Neuropath. & Exp. Neurol. 47:642-653.
30. Brady, G. W , D. B. Fein, D. D. Wood, and M A Moscarello. 1985 The role of charge microheterogeneity of human myelin basic protein in the formation of phosphatidyglycerol multilayers. Biochem. Biophys. Res. Commun. 126: 1161-1165.