Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: Crystal structure of cathepsin B-E64c complex

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1597, Issue 2, 2002, Pages 244-251

  Yamamoto, Atsushi ^a   Tomoo, Koji ^a   Matsugi, Ken Ichi ^a   Hara, Tadaoki ^a   In, Yasuko ^a   Murata, Mitsuo ^b   Kitamura, Kunihiro ^b   Ishida, Toshimasa ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cathepsin B; E64c; Molecular design; Molecular dynamics simulation; X ray crystal structure

Indexed keywords

[1 [N (3 METHYLBUTYL)AMINO]LEUCYLCARBONYL]OXIRANE 2 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; CATHEPSIN B; EPOXIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; ATOM; COVALENT BOND; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME SPECIFICITY; MOLECULAR DYNAMICS; MOLECULE; PRIORITY JOURNAL; SIMULATION; X RAY DIFFRACTION;

ANIMALS; CATHEPSIN B; CATTLE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; DRUG DESIGN; ELECTROSTATICS; LEUCINE; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0037014129     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(02)00284-4     Document Type: Article

References (30)