Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs)

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 11, 2002, Pages 1481-1484

  Drizin, Irene ^a   Holladay, Mark W ^a   Yi, Lin ^a   Zhang, Henry Q ^a   Gopalakrishnan, Sujatha ^a   Gopalakrishnan, Murali ^a   Whiteaker, Kristi L ^a   Buckner, Steven A ^a   Sullivan, James P ^a   Carroll, William A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2,4 DICHLORO 6 METHYLBENZYLAMINO) 4 (1,1 DIMETHYLPROPYLAMINO) 3 CYCLOBUTENE 1,2 DIONE; 9 (3 CYANOPHENYL) 3,4,6,7,9,10 HEXAHYDRO 1,8(2H,5H) ACRIDINEDIONE; ADENOSINE TRIPHOSPHATE; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; POTASSIUM CHANNEL; PYRAZOLOPYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; WAY 133536; CROMAKALIM; FUSED HETEROCYCLIC RINGS; GUANIDINE DERIVATIVE; N CYANO N' (1,1 DIMETHYLPROPYL) N'' (3 PYRIDINYL)GUANIDINE; N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-(3-PYRIDINYL)GUANIDINE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANIMAL; BLADDER; CELL MEMBRANE POTENTIAL; CHEMISTRY; CULTURE TECHNIQUE; DRUG EFFECT; DRUG POTENTIATION; FLUORESCENCE; GUINEA PIG; IN VITRO STUDY; SYNTHESIS;

ANIMAL; BLADDER; CELL CULTURE; CROMAKALIM; FLUORESCENCE; GUANIDINES; GUINEA PIGS; HETEROCYCLIC COMPOUNDS, 3-RING; IN VITRO; MEMBRANE POTENTIALS; POTASSIUM CHANNELS; PYRIDINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; ANIMALS; CELL CULTURE TECHNIQUES; URINARY BLADDER;

EID: 0037013429     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00207-X     Document Type: Article

References (14)