Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 17, 2002, Pages 2423-2426

  Duffy, Joseph L ^a   Kevin, Nancy J ^a   Kirk, Brian A ^a   Chapman, Kevin T ^a   Schleif, William A ^a   Olsen, David B ^a   Stahlhut, Mark ^a   Rutkowski, Carrie A ^a   Kuo, Lawrence C ^a   Jin, Lixia ^a   Lin, Jiunn H ^a   Emini, Emilio A ^a   Tata, James R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; INDINAVIR; PROTEINASE INHIBITOR; TERT BUTYLAMIDE; TRIFLUOROETHYLAMIDE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VIVO STUDY; NONHUMAN; VIRUS STRAIN; WILD TYPE; ANIMAL; CELL CULTURE; DRUG EFFECT; IC 50; METABOLIC CLEARANCE RATE; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CANIS FAMILIARIS;

ANIMALS; DOGS; DRUG RESISTANCE, MULTIPLE; HIV; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; INHIBITORY CONCENTRATION 50; METABOLIC CLEARANCE RATE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037009275     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00425-0     Document Type: Article

References (17)