Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 3, 1996, Pages 302-305

  D'Amico, Michele ^a   Berrino, Liberato ^a   Pizzirusso, Anna ^a   De Novellis, Vito ^a   Rossi, Francesco ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Glutamatergic neurotransmission; Hypertension; Raphe obscurus

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; DIZOCILPINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; HISTOLOGY; INTRACEREBRAL DRUG ADMINISTRATION; MALE; MICROINJECTION; NEUROTRANSMISSION; NONHUMAN; RAPHE NUCLEUS; RAT;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANALYSIS OF VARIANCE; ANIMALS; BENZOATES; BLOOD PRESSURE; CYCLOLEUCINE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; HYPERTENSION; MALE; MICROINJECTIONS; N-METHYLASPARTATE; NEUROTOXINS; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE;

EID: 0029998920     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168632     Document Type: Article

References (28)

1. Barnard AE, Henley JM (1990) The non-NMDA receptors: types, protein structure and molecular biology. Trends Pharmacol Sci 11:500-507
2. Baskys A (1992) Metabotropic receptors and slow excitatory action of glutamate agonists in the hippocampus. Trends Neurosci 15:92-96
3. Baude A, Nusser Z, Roberts JD, Mulvihill E, McIllhinney RA, Somogyi P (1993) The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 11:771-787
4. Bockaert J, Pin JP, Fagni L (1993) Metabotropic glutamate receptors: an original family of G protein-coupled receptors. Fundam Clin Pharmacol 7:473-485
5. Collingridge GL, Lester AJR (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 40:145
6. Coote JH (1988) The organization of cardiovascular neurones in the spinal cord. Rev Physiol Biochem Pharmacol 110:148-163
7. Craig AM, Blackstone CD, Huganir RL, Banker G (1993) The distribution of glutamate receptors in cultured rat hippocampal neurons: postsynaptic clustering of AMPA-selective subunits. Neuron 10:1055-1068
8. 1A receptor agonist into the raphe obscurus of the anaesthetized rat. Br J Pharmacol 102:317-322
9. Gilbey MP, Futuro-Neto HA, Zhou SY (1994) Respiratory-related discharge patterns of caudal raphe neurones projecting to the upper thoracic spinal cord in the rat. J Auton Nerv Syst 50: 263-273
10. Glaum SR, Miller RJ (1992) Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of solitary tract. J Neurosci 12:2251-2258
11. Gores TJ, Penke B, Boti Z, Katarova Z, Hamori J (1993) Immunohistochemical visualization of a metabotropic glutamate receptor. Neuroreport 4:283-286
12. Hornby PJ, Rossiter CD, White RL, Norman WP, Kuhn DH, Gillis RA (1990) Medullary raphe: a new site for vagally mediated stimulation of gastric motility in cats. Am J Physiol 258: G637-G647
13. Loewy AD (1981) Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res 222: 129-133
14. Lovick TA (1992) Serotonergic influence from nucleus raphe obscurus on neurones in the periaqueductal grey matter in the rat. Brain Res 606:92-98
15. Maione S, Berrino L, Vitagliano S, Leyva J, Rossi F (1992) Interactive role of L-glutamate and vasopressin, at level of the PAG area, for cardiovascular tone and stereotyped behaviour. Brain Res 597:166-169
16. Maione S, Berrino L, Leyva J, Pizzirusso A, Vitagliano S, Rossi F (1994) Effects of the polyamine spermidine on NMDA-induced arterial hypertension in freely moving rats. Neuropharmacology 33:789-793
17. Martin LJ, Blackstone CD, Uganir RL, Price DL (1992) Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron 9:259-270
18. Minson JB, Chalmers JP, Caon AC, Renaud B (1987) Separate areas of rat medulla oblongata with populations of serotonin- and adrenaline-containing neurons alter blood pressure after L-glutamate stimulation. J Auton Nerv Syst 19:39-50
19. Pawloski-Dahm C, Gordon FJ (1992) Evidence for a kynurenate-insensitive glutamate receptor in the nucleus tractus solitarii. Am J Physiol 262:H1611-H1615
20. Pitkanen M, Sirvio J, Lahtinen H, Koivisto E, Riekkinen P (1994) D-Cycloserine, a partial agonist at the glycine site, enhances the excitability of dentate granule cells in vivo in rats. Eur J Pharmacol 253:125-129
21. Schoepp D, Conn PJ (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci 14:13
22. Sladeczek F, Manzoni O, Fagni L, Dumuis A, Pin JP, Sebben M, Bockaert J (1992) The metabotropic glutamate receptor (MGR): pharmacology and subcellular localization. J Physiol (Paris) 86:47-55
23. Strack AM, Sawier WB, Hughes JH, Platt KB, Loewy AD (1989) A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infection. Brain Res 491:156-162
24. Tallarida RJ, Murray RB (1987) Manual of pharmacologic calculations with computer programs, 2nd edn. Springer, Berlin Heidelberg New York
25. Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S (1992) A family of metabotropic glutamate receptors. Neuron 8: 169-179
26. Vitagliano S, Berrino L, Pizzirusso A, D'Amico M, Calderaro V, Maione S, Rossi F (1994) Metabotropic glutamate receptors are involved in the control of breathing at medulla oblongata level of anaesthetized rats. Neuropharmacology 33:859-864
27. Wang WH, Lovick TA (1993) The inhibitory effect of the ventrolateral periaqueductal grey matter on neurones in the rostral ventrolateral medulla involves a relay in the medullary raphe nuclei. Exp Brain Res 94:295-300
28. Yool AJ, Krieger RM, Gruol DL (1992) Multiple ionic mechanisms are activated by the potent agonist quisqualate in cultured cerebellar Purkinje neurons. Brain Res 573:83-94