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Volumn 8, Issue 12, 2002, Pages 857-862

Farnesyl protein transferase inhibition interferes with activation of MAP kinase family members in human peripheral blood monocytes

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; FTI 744832; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P42; PROTEIN P44;

EID: 0037000161     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402091     Document Type: Article
Times cited : (5)

References (22)
  • 1
    • 0030962347 scopus 로고    scopus 로고
    • The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
    • Gibbs JB, Oliff A. (1997) The potential of farnesyltransferase inhibitors as cancer chemotherapeutics. Annu. Rev. Pharmacol. Toxicol. 37: 143-166.
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 143-166
    • Gibbs, J.B.1    Oliff, A.2
  • 2
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • Cox AD, Der CJ. (1997) Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? Biochim. Biophys. Acta 1333: F51-F71.
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Cox, A.D.1    Der, C.J.2
  • 3
    • 0027323459 scopus 로고
    • Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells
    • James GL, Goldstein JL, Brown MS, et al. (1993) Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. Science 260: 1937-1942.
    • (1993) Science , vol.260 , pp. 1937-1942
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 4
    • 0029000897 scopus 로고
    • Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells
    • Manne V, Yan N, Carboni JM, et al. (1995) Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells. Oncogene 10: 1763-1779.
    • (1995) Oncogene , vol.10 , pp. 1763-1779
    • Manne, V.1    Yan, N.2    Carboni, J.M.3
  • 5
    • 0028869067 scopus 로고
    • Inhibition of human tumor xenograft growth by treatment with the farnesyl protein transferase inhibitor B956
    • Nagasu T, Yoshimatsu K, Rowell C, Lewis MD, Garcia AM. (1995) Inhibition of human tumor xenograft growth by treatment with the farnesyl protein transferase inhibitor B956 Cancer Res. 55: 5310-5314.
    • (1995) Cancer Res. , vol.55 , pp. 5310-5314
    • Nagasu, T.1    Yoshimatsu, K.2    Rowell, C.3    Lewis, M.D.4    Garcia, A.M.5
  • 6
    • 0028318136 scopus 로고
    • Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton NE
    • Prendergast GC, Davide JP, deSolms SJ, et al. (1994) Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton NE. Mol. Cell. Biol. 14: 4193-4202.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4193-4202
    • Prendergast, G.C.1    Davide, J.P.2    DeSolms, S.J.3
  • 7
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • Sepp-Lorenzino L, Ma Z, Rands E, et al. (1995) A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res. 55: 5302-5309.
    • (1995) Cancer Res. , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3
  • 8
    • 0029023145 scopus 로고
    • Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion
    • Sun J, Qian Y, Hamilton AD, Sebti SM. (1995) Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res. 55: 4243-4247.
    • (1995) Cancer Res. , vol.55 , pp. 4243-4247
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 10
    • 0033016719 scopus 로고    scopus 로고
    • Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
    • Du W, Lebowitz PF, Prendergast GC. (1999) Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol. Cell. Biol. 19: 1831-1840.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1831-1840
    • Du, W.1    Lebowitz, P.F.2    Prendergast, G.C.3
  • 11
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • Sepp-Lorenzino L, Ma Z, Rands E, et al. (1995) A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res. 55: 5302-5309.
    • (1995) Cancer Res. , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3
  • 12
    • 0029150669 scopus 로고
    • Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
    • Kohl NE, Omer CA, Conner MW, et al. (1995) Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat. Med. 1: 792-797.
    • (1995) Nat. Med. , vol.1 , pp. 792-797
    • Kohl, N.E.1    Omer, C.A.2    Conner, M.W.3
  • 13
    • 0032900619 scopus 로고    scopus 로고
    • Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis
    • Norgaard P, Law B, Joseph H, et al. Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis. Clin. Cancer Res. 5: 35-42.
    • Clin. Cancer Res. , vol.5 , pp. 35-42
    • Norgaard, P.1    Law, B.2    Joseph, H.3
  • 14
    • 0033582455 scopus 로고    scopus 로고
    • Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway
    • Law BK, Norgaard P, Gnudi L, et al. (1999) Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway. J. Biol. Chem. 274: 4743-4748.
    • (1999) J. Biol. Chem. , vol.274 , pp. 4743-4748
    • Law, B.K.1    Norgaard, P.2    Gnudi, L.3
  • 15
    • 0033214846 scopus 로고    scopus 로고
    • In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
    • Mahgoub N, Taylor BR, Gratiot M, et al. (1999) In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells. Blood 94: 2469-2476.
    • (1999) Blood , vol.94 , pp. 2469-2476
    • Mahgoub, N.1    Taylor, B.R.2    Gratiot, M.3
  • 16
    • 0035160822 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo
    • van den Blink B, Juffermans NP, ten Hove T, et al. (2001) p38 mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo. J. Immunol. 166: 582-587.
    • (2001) J. Immunol. , vol.166 , pp. 582-587
    • Van Den Blink, B.1    Juffermans, N.P.2    Ten Hove, T.3
  • 17
    • 0032984348 scopus 로고    scopus 로고
    • Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
    • Sebolt-Leopold JS, Dudley DT, Herrera R, et al. (1999) Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat. Med. 5: 810-816.
    • (1999) Nat. Med. , vol.5 , pp. 810-816
    • Sebolt-Leopold, J.S.1    Dudley, D.T.2    Herrera, R.3
  • 18
    • 0037090078 scopus 로고    scopus 로고
    • Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    • Branger J, van Den Blink B, Weijer S, et al. (2002) Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. J. Immunol. 168: 4070-4077.
    • (2002) J. Immunol. , vol.168 , pp. 4070-4077
    • Branger, J.1    Van Den Blink, B.2    Weijer, S.3
  • 19
    • 0036142395 scopus 로고    scopus 로고
    • Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease
    • Hommes D, van den Blink B, Plasse T, et al. (2002) Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 122: 7-14.
    • (2002) Gastroenterology , vol.122 , pp. 7-14
    • Hommes, D.1    Van Den Blink, B.2    Plasse, T.3
  • 20
    • 0035913984 scopus 로고    scopus 로고
    • Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells
    • Mizukami Y, Ura H, Obara T, et al. (2001) Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells. Biochem. Biophys. Res. Commun. 288: 198-204.
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , pp. 198-204
    • Mizukami, Y.1    Ura, H.2    Obara, T.3
  • 21
    • 0027326410 scopus 로고
    • Protein kinase C alpha activates RAF-1 by direct phosphorylation
    • Kolch W, Heidecker G, Kochs G, et al. (1993) Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature 364: 249-252.
    • (1993) Nature , vol.364 , pp. 249-252
    • Kolch, W.1    Heidecker, G.2    Kochs, G.3
  • 22
    • 0028892646 scopus 로고
    • Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
    • Lebowitz PF, Davide JP, Prendergast GC. (1995) Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol. Cell. Biol. 15: 6613-6622.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6613-6622
    • Lebowitz, P.F.1    Davide, J.P.2    Prendergast, G.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.