Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain

Journal of Clinical Pharmacology

Volumn 38, Issue 12 SUPPL., 1998, Pages

  McGurk, Mark ^a   Robinson, Paul ^b   Rajayogeswaran, Vairavapillai ^a   De Luca, Massimo ^c   Casini, Alessandro ^c   Artigas, Remei ^d   Muñoz, Genís ^d   Mauleón, David ^d  

^a GUY S HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL LEWISHAM   (United Kingdom)

^c Menarini Ricerche SpA   (Italy)

^d Laboratorios Menarini SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; DEXKETOPROFEN; KETOPROFEN; PARACETAMOL;

ADULT; ANALGESIC ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FAINTNESS; FEMALE; FEVER; HEADACHE; HUMAN; LETHARGY; MAJOR CLINICAL STUDY; MALE; MUSCLE WEAKNESS; ORAL DRUG ADMINISTRATION; PAIN ASSESSMENT; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; TOOTH PAIN;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KETOPROFEN; MALE; MOLAR, THIRD; PAIN, POSTOPERATIVE; TOOTH EXTRACTION; TREATMENT OUTCOME; TROMETHAMINE;

EID: 0032416892     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Veys EM: 20 years' experience with ketoprofen. Scand J Rheumatol Suppl 1991;90:1-44.
2. Hayball PJ, Nation RL, Bochner F: Enantioselective pharmacodynamics of the nonsteroidal anti-inflammatory drug ketoprofen: in vitro inhibition of human platelet cyclooxygenase activity. Chirality 1992;4:484-487.
3. Suesa N, Fernandez MF, Gutierrez M, Rufat MJ, Rotllan E, Calvo L, Mauleon D, Carganico G. Stereoselective cyclooxygenase inhibition in cellular models by the enantiomers of ketoprofen. Chirality 1993;5:589-595.
4. Mauleón D, Artigas R, García ML, Carganico G: Preclinical and clinical development of dexketoprofen. Drugs 1996;52(Suppl 5): 34-46.
5. Gich I, Bayés MJ, Barbanoj MJ, et al: Bioinversion of R(-)-ketoprofen after oral administration in healthy volunteers. Clin Drug Invest 1996;11:347-353.
6. Rudy AC, Liu Y, Brater C, Hall SD: Stereoselective pharmacokinetics and inversion of (R)-ketoprofen in healthy volunteers. J Clin Pharmacol 1998;38:3S-10S.
7. Evans AM: Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs. Eur J Clin Pharmacol 1992;42:237-256.
8. Palomer A, Cabré M, Ginesta J, Mauleón D, Carganico G: Resolution of rac-ketoprofen esters by enzymatic reactions in organic media. Chirality 1993;5:320-328.
9. Carganico G, Mauleón D, García ML: A novel arylpropionic derivative, its method of preparation and its application as an analgesic. Patent WO9411332, 1994.
10. Cooper SA, Beaver WT: A model to evaluate mild analgesics in dental pain. Clin Pharmacol Ther 1976;20:241-250.
11. Cooper S, Gelb SB, Maggio Cavaliere MB, Cohn P, Dyer C: An analgesic relative potency assay comparing ketoprofen and aspirin in postoperative dental pain. Adv Ther 1984;1:410-418.
12. Mehlisch D, Frakes L, Cavaliere MB, Gelman M: Double-blind parallel comparison of single oral doses of ketoprofen, codeine and placebo in patients with moderate to severe dental pain. J Clin Pharmacol 1984;24:486-492.
13. Cooper SA, Berrie R, Cohn P: Comparison of ketoprofen, ibuprofen and placebo in a dental surgery pain model. Adv Ther 1988;5:43-53.
14. Forbes AJ: Oral surgery, in Max MB, Portenoy RK, Laska EM (eds): Advances in Pain Research and Therapy. Vol. 18. The Design of Analgesic Clinical Trials. New York: Raven Press, 1991; 347-374.
15. Levin LM, Cooper SA, Betts NJ, Wedell D, Hermann DG, Lamp C, Secreto SA, Hersh EV: Ketoprofen dental pain study. J Clin Dentistry 1997;4:103-106.
16. Gay C, Planas E, Donado M, Martínez JM, Artigas R, Torres F, Mauleón D, Carganico G: Analgesic efficacy of low doses of dexketoprofen in the dental pain model. A randomised, double-blind, placebo-controlled study. Clin Drug Invest 1996;11:320-330.
17. Geisslinger G, Ferreira SH, Menzel S, Schlott D, Brune K: Antinociceptive actions of R(-)-flurbiprofen - a non-cyclooxygenase inhibiting 2-arylpropionic acid in rats. Life Sci 1994;54:173-177.
18. Lotsch J, Geislinger G, Mohammadian P, Brune K, Kobal G: Effects of flurbiprofen enantiomers on pain-related chemosomatosensory evoked potentials in human subjects. Br J Clin Pharmacol 1995;40:339-346.
19. Geisslinger G, Schaible HG: New insights into the site and mode of antinociceptive action of flurbiprofen enantiomers. J Clin Pharmacol 1996;36:513-520.
20. Cooper SA, Reynolds DC, Reynolds B, Hersh EV: Analgesic efficacy and safety of (R)-ketoprofen in postoperative dental pain. J Clin Pharmacol 1998;38:11S-18S.