Complement activating antibodies against the human 60 kDa heat shock protein as a new independent family risk factor of coronary heart disease

European Journal of Clinical Investigation

Volumn 32, Issue 6, 2002, Pages 405-410

  Veres, A ^a   Szamosi, T ^a   Ablonczy, M ^a   Szamosi Jr , T ^a   Singh, M ^b   Karadi I ^a,c   Romics, L ^a,c   Fust G ^a,c   Prohaszka Z ^a,c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH   (Germany)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Children; Cholesterol; Complement activating antibodies; Coronary heart disease; Family risk; Heat shock protein 60

Indexed keywords

AUTOANTIBODY; COMPLEMENT ACTIVATING ANTIBODY; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 65; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN G ANTIBODY; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UNCLASSIFIED DRUG;

ADOLESCENT; AGE; ANTIBODY BLOOD LEVEL; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILIAL DISEASE; FEMALE; HUMAN; ISCHEMIC HEART DISEASE; LEUKOCYTE COUNT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; SMOKING;

ADOLESCENT; AUTOANTIBODIES; CHAPERONIN 60; CHILD; COMPLEMENT ACTIVATION; CORONARY DISEASE; FEMALE; HUMANS; HUNGARY; LIPIDS; MALE; MYOCARDIAL INFARCTION; REGRESSION ANALYSIS; RISK FACTORS;

EID: 0036997958     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2002.01007.x     Document Type: Article

References (32)

1. Barrett-Connor E, Khaw K-T. Family history of heart attack as an independent predictor of death due to cardiovascular disease. Circulation 1984;69:1065-9.
2. Shea S, Ottman R, Gabrieli C, Stein Z, Nichols A. Family history as an independent risk factor for coronary artery disease. JACC 1984;4:793-801.
3. Schildkraut JM, Myers RH, Cupples A, Kyeli DK, Kannel WB. Coronary risk associated with age and sex of parental heart disease in the Framingham study. Am J Cardiol 1989;64:555-9.
4. Myers RH, Kiely DK, Cupples A, Kannel WB. Parental history is an independent risk factor for coronary artery disease: the Framingham study. Am Heart J 1990;120:963-9.
5. Jousilahti P, Puska P, Vartiainen E, Pekkanen J, Tuomilehto J. Parental history of premature coronary heart disease: an independent risk factor of myocardial infarction. J Clin Epidemiol 1996;49:497-503.
6. Higgins M. Epidemiology and prevention of coronary heart disease in families. Am J Med 2000;108:387-95.
7. Marenberg M, Risch N, Berkman LF, Floderus B, de Faire U. Genetic susceptibility from coronary heart disease in a study of twins. New Eng J Med 1994;330:1041-6.
8. Heller DA, de Faire U, Pedersen NL, Dahlen G, McClearn GE. Genetic and environmental influences on serum lipid levels in twins. New Engl J Med 1993;328:1150-6.
9. Prohászka Z, Duba J, Horváth L, Császár A, Karádi I, Szebeni A. Comparative study on antibodies to human and bacterial 60 kD heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects. Eur J Clin Invest 2001;31:285-92.
10. Zhu J, Quyyumi AA, Rott D, Csako Gy, Wu H, Halcox Jet al. Antibodies to human heat shock protein 60 are associated with the presence and severity of coronary artery disease. Evidence for an autoimmune component of atherosclerosis. Circulation 2001;103:1071-5.
11. Hopplicher F, Lechleitner M, Traweger C, Schett G, Dzien A, Sturm W et al. Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction. Atherosclerosis 1996;126:333-41.
12. Birnie DH, Holme ER, McKay IC, Hood S, McColl KE, Hillis WE. Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk. Eur Heart J 1998;19:387.
13. Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhollenzer F et al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Clinical significance determined in a follow-up study. Circulation 1999;100: 1169-74.
14. Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl Set al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet 1993;341: 255-6.
15. Mukherjee M, De Benedictis C, Jewitt D, Kakkar WW. Association of antibodies to heat-shock protein 65 with percutaneous transluminal coronary angioplasty and subsequent restenosis. Thromb Haemost 1996;75:258.
16. Hoppichler F, Koch T, Dzien A, Gschwandtner G, Lechleitner M. Prognostic value of antibody titre to heat-shock protein 65 on cardiovascular events. Cardiology 2000;94:220-3.
17. Burian K, Kis Z, Virok D, Endresz V, Prohászka Z, Duba J et al. Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis. Circulation 2001;103:1503-8.
18. Prohászka Z, Duba J, Lakos G, Kiss E, Varga L, Jánoskúti L. Antibodies against human hsp60 and mycobacterial hsp65 differ in their antigen specificity and complement activating ability. Int Immunol 1999;11:1363-70.
19. Friedewald JT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
20. Genest JJ Jr, Martin-Munley SS, McNamara JR, Ordovas JM, Jenner J, Myers RH. Familial lipoprotien disorders in patients with premature coronary artery disease. Circulation 1992;85:2025-33.
21. Cohen IR, Young DB. Autoimmunity, microbal immunity and the immunological homunculus. Immunol Today 1991;12: 105-8.
22. Schwartz M, Cohen IR. Autoimmunity can benefit self-maintenance. Immunol Today 2000;21:265-8.
23. Xu Q, Wick G. The role of heat shock proteins in protection and pathophysiology of the arterial wall. Mol Med Today 1996;2:372.
24. Rodman TC, To SE, Sullivan JJ, Winston R. Innate natural antibodies. Primary roles indicated by specific epitopes. Hum Immunol 1997;55:87-95.
25. Lacroix-Desmazes S. Self-reactive antibodies (natural antibodies) in healthy individuals. J Immunol Methods 1999;216:2-3.
26. Menoret A, Chandawarkar RY, Srivastava PK. Natural autoantibodies against heat-shock proteins hsp70 and gp96: implications for immunotherapy using heat-shock proteins. Immunology 2000;101:364-70.
27. Grandia AA, de Visser H, van Embden JD, van der Zee R, van den Berg WB et al. Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for Mycobacterium tuberculosis induced adjuvant arthritis. Immunobiology 1991;182:127-34.
28. Mayr M, Metzler B, Kiechl S, Willeit J, Schett G, Xu Qet al. Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae. Circulation 1999;99:1560-6.
29. Torzewski J, Bowyer DE, Waltenberg J, Fitzsimonns C. Processes in atherogenesis: complement activation. Atherosclerosis 1997;132:141-5.
30. Ross R. Atherosclerosis - An inflammatory disease. New Engl J Med 1999;340:115.
31. Schett G, Xu Q, Amberger A, van der Zee R, Recheis H, Willeit J et al. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest 1995;96:2569-77.
32. Schett G, Metzler B, Mayr M, Amberger A, Niederwieser D, Gupta RS. Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60. Atherosclerosis 1997;128:27-38.