One pot solid phase synthesis of isoxazolines

Tetrahedron Letters

Volumn 39, Issue 17, 1998, Pages 2447-2448

  Shankar, B B ^a   Yang, D Y ^a   Girton, S ^a   Ganguly, A K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOXAZOLE DERIVATIVE; ISOXAZOLINE DERIVATIVE; NITRIC OXIDE;

ARTICLE; CHEMICAL STRUCTURE; CYCLIZATION; DIMERIZATION; PURIFICATION; SYNTHESIS;

EID: 0032560063     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00237-8     Document Type: Article

References (9)

1. 1. Torssell, K. B. G. Nitrile Oxides, Nitrones and Nitronates in Organic Synthesis, VCH Publishers: New York, 1988.
2. 2. Kozikowski, A. P. Acc. Chem. Res. 1984, 17, 410.
3. 3. Whitney, R. A.; Nicholas, E. S. Tetrahedron Lett, 1981, 35, 3371.
4. 4. For a recent comprehensive review see: Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. C. Tetrahedron, 1997, 53, 5643.
5. 2, DMF, DMF / water (1:1), water, EtOH, and diethyl ether.
6. 6. Sample of the resin was washed and dried. The resin was ground into fine powder and a pellet was made after mixing with KBr.
7. 7. Paton, R. M.; Young, A. A. J. Chem. Soc., Chem. Commun., 1994, 8, 993.
8. 8. DeWitt, S.H.; Czarnik, A. W. Acc. Chem. Res. 1996, 29, 114. (The kit was purchased from Chem Glass. Inc., Vineland, N. J. 08360.)
9. 3) 3.35 (dd, J = 16.0, 7.5 Hz, 1H), 3.8 (dd, J = 16.0, 10.0 Hz, 1H), 5.78 (dd, J = 10.0, 7.5 Hz, 1H), 6.9 (d, J = 7.5 Hz, 2H), 7.4 (m, 5H), 7.65 (d, J = 7.5 Hz, 2H).