Expanding on the purification methodology of polyethylene glycol (PEG) bound molecules: The synthesis of 3,5-pyrazolidinediones

Tetrahedron Letters

Volumn 39, Issue 46, 1998, Pages 8433-8436

  Zhao, Xu Yang ^a   Metz, William A ^a   Sieber, Frank ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC COMPOUND; MACROGOL; PYRAZOLE DERIVATIVE; PYRAZOLIDINE 3,5 DIONE DERIVATIVE; UNCLASSIFIED DRUG;

CHEMICAL STRUCTURE; DRUG PURIFICATION; PRECIPITATION; REVIEW; SYNTHESIS;

EID: 0032511939     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01921-2     Document Type: Article

References (15)

1. 1. Gravert, D. J.; Janda, K. D. Chem. Rev. 1997, 97, 489.
2. 2. Han, H.; Wolfe, M. M.; Brenner, S.; Janda, K. D. Proc. Natl. Acad. Sci. 1995, 92, 6419.
3. 3. a) The Organic Chemistry of Drug Synthesis; Lednicer, D.; Mitschner, L. A.; Eds.; John Wiley and Sons, New York, Vol. 1, 1977, p 234.
4. b) Buchanan, M. R. Thromb. Res. 1983, Issue Suppl. IV, 89.
5. c) Margulies, E. H.; White, A. M. Pharmacol. Biochem. Prop. Drug. Subst. 1979, 2, 255.
6. d) Heming, A. E.; Kuzell, W. C. Antibiot. Chemother. 1953, 3, 634.
7. e) Pfister, R.; Hafliger, F. Helv. Chim. Acta. 1961, 44, 232.
8. f) Sherry, S. et. al. N. Eng. J. Med. 1978, 298, 289; 1980, 302, 250.
9. g) El-Rayyes, N. R.; Al-Awadi, N. A. Synthesis 1985, 1028.
10. 4. Arriau, J.; Deschamps, J.; Teysseyre, J.; Maquestiau, A.; van Haverbeke, Y. Tetrahedron 1974, 30, 1225.
11. 5. El-Rayyes, N. R.; Al-Awadi, N. A. Synthesis 1985, 1028.
12. 6. Zhao, X.; Janda, K. D. Tetrahedron Lett. 1997, 38, 5437.
13. 7. Zhao, X.; Janda, K. D. Bioorg. Med. Chem. Lett. in press.
14. 8. For recent review on polymer supported reactions see: (a) Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. C. Tetrahedron 1997, 53, 5643.
15. (b) Chaiken, I. M. and Janda, K. D. Molecular Diversity and Combinatorial Chemistry, Libraries and Drug Design; ACS: Washington, D. C., 1996; Conference Proceedings Series III.