Synthesis and structure-activity relationship of dehydroxymethylepoxyquinomicin analogues as inhibitors of NF-κB functions

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 12, 2002, Pages 3933-3939

  Chaicharoenpong, Chanya ^a   Kato, Kuniki ^b   Umezawa, Kazuo ^a  

^a KEIO UNIVERSITY   (Japan)

^b NIPPON KAYAKU CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHOXY N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 2 HEXYLOXY N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 2 METHOXY N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 2 METHYL N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 2 PHENOXY N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 3 CHLORO N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 3 FLUORO N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 3 HYDROXY N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; 4 HYDROXY N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; BIOTIN; HYDROXYL GROUP; I KAPPA B; N (2 HYDROXY 3,4 EPOXY 5 OXOCYCLOHEX 6 ENYL)BENZAMIDE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; LEUKEMIA CELL; LEUKEMIA CELL LINE; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; BENZAMIDES; CYCLOHEXANONES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; JURKAT CELLS; NF-KAPPA B; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036978903     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00315-2     Document Type: Article

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