Ceramide is involved in MPP+-induced cytotoxicity in human neuroblastoma cells

Korean Journal of Physiology and Pharmacology

Volumn 6, Issue 6, 2002, Pages 281-286

  Nam, Eun Joo ^b   Lee, Hye Sook ^b   Lee, Young Jae ^a   Joo, Wan Seok ^b   Maeng, Sungho ^b   Im, Hye In ^b   Park, Chan Woong ^b   Kim, Yong Sik ^b  

^a Gachon University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Ceramide activated protein phosphate; Dopaminergic neuroblastoma; MPP+; Sphingomyelinase

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CERAMIDE; ENZYME INHIBITOR; ETHANOLAMINE DERIVATIVE; FUMONISIN B1; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

CELL DEATH; CELL LEVEL; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIPID DEGRADATION; MEDIATOR; METHODOLOGY; NEUROBLASTOMA CELL; REVIEW;

EID: 0036977947     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. Brugg B, Michel PP, Agid Y, Ruberg M. Ceramide, induces apoptosis in cultured mesencephalic neurons. J Neurochem 66: 733-739, 1996
2. Chan C, Goldkorn T. Ceramide path in human lung cell death. Am J Respir Cell Mol Biol 22: 460-468, 2000
3. Cleeter MW, Coope JM, Schpira HV. Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement. J Neurochem 58: 786-789, 1992
4. +) cytotoxicity. Biochem Biophys Res Commun 137: 303-309, 1986
5. Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem 268: 15523-15530, 1993
6. Dressler KA, Kolesnik RN. Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin. J Biol Chem 265: 14917-14921, 1990.
7. Fernandez-checa JC, Ren C, Aw TY, Ookhtens M, Kaplowitz N. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes. Am J Physiol 255: G403-408, 1988
8. + and MPTP in PC12 cells independent of reactive oxygen species formation. Brain Res 905: 199-206, 2001
9. Gamard CJ, Blobe GC, Hannun YA, Obeid LM. Specific role for protein kinase C in cell differentiation. Cell Growth Differ 5: 405-409, 1994
10. Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 274: 1855-1859, 1996
11. Hauser JM, Buehrer BM, Bell RM. Role of ceramide in mitogenesis induced by exogenous sphingoid bases. J Biol Chem 269: 6803-6809, 1994
12. Heller RA, Kronke M. Tumor necrosis factor receptor-mediated signaling pathways. J Cell Biol 126: 5-9, 1994
13. Jarvis WD, Kolesnick RN, Fornari FA, Taylor RS, Gewirtz DA, Grant S. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc Natl Acad Sci 91: 73-77, 1994
14. 1-induced apoptosis. Environ Health Perspect 109(S2): 315-320, 2001
15. Kolesnick RN, Golde DW. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77: 325-328, 1994
16. Kopin IJ, Markey SP. MPTP toxicity: implications for research in Parkinson's disease. Ann Rev Neurosci 11: 81-96, 1988
17. Kowluru A, Metz SA. Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells. FEBS Lett 418: 179-182, 1997
18. Kroesen BJ, Pettus B, Luberto C, Busman M, Sietsma H, de Leij L, Hannun YA. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem 276: 13604-13614, 2001
19. + increases the vulnerability of oxidative stress rather than directly mediating oxidative damage in human neuroblastoma cells. Exp Neurol 165: 164-171, 2000
20. Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor- α -induced cell death. J Biol Chem 273: 11313-11320, 1998
21. Martinovits G, Melamed E, Cohen O, Rosental J, Uzzan A. Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurosci Lett 69: 192-197, 1986
22. Mihatsch W, Russ H, Gerlach M, Riederer P, Przuntek H. Treatment with antioxidants does not prevent loss of dopamine in the striatum of MPTP-treated common marmosets. J Neural Transm Park Dis Dement Sect 3: 73-78, 1991
23. Mithofer K, Sandy MS, Smith MT. Mitochondrial poisons cause depletion of reduced glutathione in isolated hepatocytes. Arch Biochem Biophys 295: 132-136, 1992
24. Nakamura K, Bindoras VP, Marks JD, Wright DA, From DM, Miller RJ, Kang UJ. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol 58: 271-278, 2000
25. Nickels JY, Broach JR. A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev, 10: 382-394, 1996
26. Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science 259: 1769-1771, 1993
27. Phelps DT, Ferro TJ, Higgins PJ, Shankar R, Parker DM, Johnson A. TNF-α induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C. Am J Physiol 269: L551-559, 1995
28. Prinetti A, Bassi R, Riboni L, Tettamanti G. Involvement of ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells. FEBS Lett 414: 475-479, 1997
29. Ross RA, Spengler BA, Biedler JL. Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J Natl Cancer Inst 71: 741-749, 1983
30. Salinas M, Lopez-Valdaliso R, Martin D, Alvarez A, Cuadrado A. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Mol Cell Neurosci 15: 156-169, 2000
31. Sharma RP, Bhandari N, He Q, Riley RT, Voss KA. Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1. Toxicology 159: 69-79, 2001
32. Takahashi T, Deng Y, Maruyama W, Dostert P, Kawai M. Naoi M. Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydrohydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system. J Neural Transm Geri Sect 98: 107-118, 1994
33. van den Dobbelsteen DJ, Nobel CSI, Schlegel J, Cotgreave IA, Orrenius S, Slater AF. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J Biol Chem 271: 15420-15427, 1996
34. Vento R, Giuliano M, Lauricella M, Carabillo M, Di Liberto D, Tesoriere G. Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide. Mol Cell Biochem 185: 1-7, 1998
35. Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 269: 19605-19609, 1994
36. Yoshimura S, Banno Y, Nakashima S, Takenaka K, Sakai H, Nishimura Y, Sakai N, Shimizu S, Eguchi Y, Tsujimoto Y, Nozawa Y. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J Biol Chem 273: 6921-6927, 1998
37. Yoshimura S, Banno Y, Nakashima S, Hayashi K, Yamakawa H, Sawada M, Saiai N, Nozawa Y. Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. J Neurochem 73: 675-683, 1999