T cells and mast cells as a major source of interleukin-13 in atopic dermatitis

Dermatology

Volumn 205, Issue 1, 2002, Pages 11-17

  Obara, Wataru ^a   Kawa, Yoko ^a   Ra, Chisei ^b   Nishioka, Kusuki ^a   Soma, Yoshinao ^a   Mizoguchi, Masako ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Atopic dermatitis; Interleukin 13; Mast cells; T cells; Th2

Indexed keywords

INTERLEUKIN 13; MESSENGER RNA;

ADULT; ARTICLE; ATOPIC DERMATITIS; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MAST CELL; MICROSCOPE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; SKIN DEFECT; T LYMPHOCYTE;

ADULT; ANTIGENS, CD3; DERMATITIS, ATOPIC; FEMALE; HUMANS; IMMUNOGLOBULIN E; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-13; MALE; MAST CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; T-LYMPHOCYTES;

EID: 0036975938     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063145     Document Type: Article

References (17)

1. Stone SP, Muller SA, Gleich GJ: IgE levels in atopic dermatitis. Arch Dermatol 1973;108:806-811.
2. Jujo K, Renz H, Abe J, Gelfand EW, Leung DYM: Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis. J Allergy Clin Immunol 1992;90:323-331.
3. Tang MLK, Kemp AS: Spontaneous expression of IL-4 mRNA in lymphocytes from children with atopic dermatitis. Clin Exp Immunol 1994;97:491-498.
4. Hamid Q, Boguniewicz M, Leung DYM: Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 1994;94:870-876.
5. Kapsenberg ML, Wierenga EA, Bos JD, Jansen HM: Functional subsets of allergen-reactive human CD4+ T cells. Immunol Today 1991;12:392-395.
6. Grewe M, Gyufko K, Schöpf E, Krutmann J: Lesional expression of interferon-γ in atopic eczema. Lancet 1994;343:25-26.
7. Minty A, Chalon P, Derocq JM, Dumont X, Guillemot J-C, Kaghad M, Labit C, Leplatois P, Liauzun P, Miloux B, Minty C, Casellas P, Loison G, Lupker J, Shire D, Ferrara P, Caput D: Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993;362:248-250.
8. Zurawski G, de Vries JE: Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994;15:19-26.
9. Pawankar RU, Okuda M, Hasegawa S, Suzuki K, Yssel H, Okubo K, Okumura K, Ra C: Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis. Am J Respir Crit Care Med 1995;152:2059-2067.
10. Hamid Q, Naseer T, Minshall EM, Song YL, Boguniewicz M, Leung DYM: In vivo expression of IL-12 and IL-13 in atopic dermatitis. J Allergy Clin Immunol 1996;98:225-231.
11. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980;92(suppl):44-47.
12. Burd PR, Thompson WC, Max EE, Mills FC: Activated mast cells produce interleukin 13. J Exp Med 1995;181:1373-1380.
13. Ochensberger B, Daepp GC, Rihs S, Dahinden CA: Human blood basophils produce interleukin-13 in response to IgE-receptor-dependent and -independent activation. Blood 1996;88:3028-3037.
14. Akdis A, Akdis M, Simon D, Dibbert B, Weber M, Gratzl S, Kreyden O, Disch R, Wüthrich B, Blaser K, Simon H-U: T-cells and T-cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J Invest Dermatol 1999;113:628-634.
15. Takamatsu Y, Hasegawa M, Sato S, Takehara K: IL-13 production by peripheral blood mononuclear cells from patients with atopic dermatitis. Dermatology 1998;196:377-381.
16. Sato A, Tsuji K, Yamamura M, Morita Y, Kanzaki H, Tada J, Makino H, Arata J: Increased type 2 cytokine expression by both CD4+CD45RO+ T cells and CD8+CD45RO+ T cells in blood circulation is associated with high serum IgE but not with atopic dermatitis. J Invest Dermatol 1998;111:1079-1084.
17. Farrell AM, Antrobus P, Simpson D, Powell S, Chapel HM, Ferry BL: A rapid flow cytometric assay to detect CD4+ and CD8+ T-helper (Th)0, Th1 and Th2 cells in whole blood and its application to study cytokine levels in atopic dermatitis before and after cyclosporin therapy. Br J Dermatol 2001;144:24-33.