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Journal of Receptors and Signal Transduction

Volumn 22, Issue 1-4, 2002, Pages 241-252

Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor

(3) Heding, A a Elling, C E a Schwartz, T W a

a 7TM Pharma A S (Denmark)

Author keywords

Calcium measurements; Engineered metal ion bending site; Medium throughput screening; NK 1 receptor

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; CYCLIC AMP; METAL ION; NEUROKININ 1 RECEPTOR; NOLPITANTIUM; SUBSTANCE P;

CALCIUM SIGNALING; CONFERENCE PAPER; EQUIPMENT; FLUORESCENCE; HUMAN; LIQUID; LUMINESCENCE; PIPETTE; ROBOTICS; SIGNAL TRANSDUCTION;

ANIMALS; BIPHENYL COMPOUNDS; CALCIUM; CALCIUM SIGNALING; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; MUTAGENESIS, SITE-DIRECTED; PHOSPHATIDYLINOSITOLS; PIPERIDINES; QUINUCLIDINES; RECEPTORS, NEUROKININ-1; STEREOISOMERISM; SUBSTANCE P; ZINC;

EID: 0036975892 PISSN: 10799893 EISSN: 15324281 Source Type: Journal
DOI: 10.1081/RRS-120014599 Document Type: Conference Paper

Times cited : (14)

References (10)

1
- 0035827631
- Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis
- Holst, B.; Hastrup, H.; Raffetseder, U.; Martini, L.; Schwartz, T.W. Two Active Molecular Phenotypes of the Tachykinin NK1 Receptor Revealed by G-Protein Fusions and Mutagenesis. J. Biol. Chem. 2001, 276, 19793-19799.
- (2001) J. Biol. Chem. , vol.276 , pp. 19793-19799
- Holst, B.¹ Hastrup, H.² Raffetseder, U.³ Martini, L.⁴ Schwartz, T.W.⁵

2
- 0028800729
- Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor
- Elling, C.E.; Nielsen, S.M.; Schwartz, T.W. Conversion of Antagonist-Binding Site to Metal-Ion Site in the Tachykinin NK-1 Receptor. Nature 1995, 374, 74-77.
- (1995) Nature , vol.374 , pp. 74-77
- Elling, C.E.¹ Nielsen, S.M.² Schwartz, T.W.³

3
- 0031914895
- Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor
- Holst, B.; Zoffmann, S.; Elling, C.E.; Hjorth, S.A.; Schwartz, T.W. Steric Hindrance Mutagenesis Versus Alanine Scan in Mapping of Ligand Binding Sites in the Tachykinin NK1 Receptor. Mol. Pharmacol. 1998, 53, 166-175.
- (1998) Mol. Pharmacol. , vol.53 , pp. 166-175
- Holst, B.¹ Zoffmann, S.² Elling, C.E.³ Hjorth, S.A.⁴ Schwartz, T.W.⁵

4
- 0027933763
- Locating ligand-binding sites in 7TM receptors by protein engineering
- Schwartz, T.W. Locating Ligand-Binding Sites in 7TM Receptors by Protein Engineering. Curr. Opinion Biotechnol. 1994, 5, 434-444.
- (1994) Curr. Opinion Biotechnol. , vol.5 , pp. 434-444
- Schwartz, T.W.¹

5
- 0033607270
- Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor
- Elling, C.E.; Thirstrup, K.; Holst, B.; Schwartz, T.W. Conversion of Agonist Site to Metal-Ion Chelator Site in the Beta(2)-Adrenergic Receptor. Proc. Natl. Acad. Sci. USA 1999, 96, 12322-12327.
- (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12322-12327
- Elling, C.E.¹ Thirstrup, K.² Holst, B.³ Schwartz, T.W.⁴

6
- 0029957956
- Connectivity and orientation of the seven helical bundle in the tachykinin NK-1 receptor probed by zinc site engineering
- Elling, C.E.; Schwartz, T.W. Connectivity and Orientation of the Seven Helical Bundle in the Tachykinin NK-1 Receptor Probed by Zinc Site Engineering. EMBO J. 1996, 15, 6213-6219.
- (1996) EMBO J. , vol.15 , pp. 6213-6219
- Elling, C.E.¹ Schwartz, T.W.²

7
- 0030634725
- Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors
- Elling, C.E.; Thirstrup, K.; Nielsen, S.M.; Hjorth, S.A.; Schwartz, T.W. Engineering of Metal-Ion Sites as Distance Constraints in Structural and Functional Analysis of 7TM Receptors. Fold. Des. 1997, 2, S76-S80.
- (1997) Fold. Des. , vol.2
- Elling, C.E.¹ Thirstrup, K.² Nielsen, S.M.³ Hjorth, S.A.⁴ Schwartz, T.W.⁵

8
- 0029873472
- Construction of a high affinity zinc switch in the kappa-opioid receptor
- Thirstrup, K.; Elling, C.E.; Hjorth, S.A.; Schwartz, T.W. Construction of a High Affinity Zinc Switch in the Kappa-Opioid Receptor. J. Biol. Chem. 1996, 271, 7875-7878.
- (1996) J. Biol. Chem. , vol.271 , pp. 7875-7878
- Thirstrup, K.¹ Elling, C.E.² Hjorth, S.A.³ Schwartz, T.W.⁴

9
- 0033944938
- Partial agonism through a zinc-ion switch constructed between transmembrane domains VII in the tachykinin NK(1) receptor
- Holst, B.; Elling, C.E.; Schwartz, T.W. Partial Agonism Through a Zinc-Ion Switch Constructed Between Transmembrane Domains III and VII in the Tachykinin NK(1) Receptor. Mol. Pharmacol. 2000, 58, 263-270.
- (2000) Mol. Pharmacol. , vol.58 , pp. 263-270
- Holst, B.¹ Elling, C.E.² Schwartz T.W. III³

10
- 12244285355
- Intracellular calcium assay preformed on novostar microtiter plate reader
- Heding, A. Intracellular Calcium Assay Preformed on NovoStar Microtiter Plate Reader. BMG Application Note (2001).
- (2001) BMG Application Note
- Heding, A.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.