Splenic denervation blocks leptin-induced enhancement of humoral immunity in Siberian hamsters (Phodopus sungorus)

Neuroendocrinology

Volumn 76, Issue 3, 2002, Pages 178-184

  Demas, Gregory E ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Adrenal; Catecholamines; Energy balance; Hamster; Neuroimmune interactions; Photoperiod; Spleen; Splenic denervation

Indexed keywords

KEYHOLE LIMPET HEMOCYANIN; LEPTIN;

ADIPOSE TISSUE; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; BODY FAT; CONTROLLED STUDY; DENERVATION; HAMSTER; HORMONAL REGULATION; HORMONE RELEASE; HUMORAL IMMUNITY; MALE; NONHUMAN; OSMOTIC MINIPUMP; PHODOPUS; PHOTOPERIODICITY; PRIORITY JOURNAL; SPLEEN;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; BODY WEIGHT; CRICETINAE; DENERVATION; HEMOCYANIN; LEPTIN; MALE; ORGAN SIZE; PHODOPUS; PHOTOPERIOD; SPLEEN; SYMPATHETIC NERVOUS SYSTEM; TESTIS;

EID: 0036973448     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064527     Document Type: Article

References (38)

1. Bronson F, Heideman PD: Seasonal regulation of reproduction in mammals; in Knobil E, Neill JD (eds): The Physiology of Reproduction, ed 2. New York, Raven Press, 1994, vol 2, pp 541-584.
2. Maier SF, Watkins LR, Fleshner M: Psychoneuroimmunolgy: The interface between behavior, brain, and immunity. Am Psychol 1994;49:1004-1017.
3. Demas GE, Chefer VC, Talan MI, Nelson RJ: Metabolic costs of mounting an antigen-stimulated immune response in adult and aged C57BL/6J mice. Am J Physiol 1997;273:R1631-R1637.
4. Lochmiller RL, Deerenberg C: Trade-offs in evolutionary immunology: Just what is the cost of immunity? Oikos 2000;88:87-98.
5. Nelson RJ, Demas GE: Seasonal changes in immune function. Q Rev Biol 1996;71:511-548.
6. Sheldon BC, Verhulst S: Ecological immunology: Costly parasite defenses and trade-offs in evolutionary ecology. TREE 1996;11:317-321.
7. Woods SC, Seeley RJ: Adiposity signals and the control of energy homeostasis. Nutrition 2000;16:894-902.
8. Van Dijk G: The role of leptin in the regulation of energy balance and adiposity. J Neuroendocrinol 2001;13:913-921.
9. Drazen DL, Demas GE, Nelson RJ: Leptin effects on immune function and energy balance are photoperiod dependent in Siberian hamsters (Phodopus sungorus). Endocrinology 2001;142:2768-2775.
10. Havel PJ: Peripheral signals conveying metabolic information to the brain: Short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med 2001;226:963-977.
11. Elmquist JK: Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Physiol Behav 2001;74:703-708.
12. Mizuno A, Murakami T, Otani S, Kuwajima M, Shima K: Leptin affects pancreatic endocrine functions through the sympathetic nervous system. Endocrinology 1998;139:3863-3870.
13. Rayner DV: The sympathetic nervous system in white adipose tissue regulation. Proc Nutr Soc 2001;60:357-364.
14. Scarpace PJ, Matheny M, Moore RL, Kumar MV: Modulation of uncoupling protein 2 and uncouplin protein 3: Regulation by denervation, leptin and retinoic acid treatment. J Endocrinol 2000;164:331-337.
15. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897-901.
16. Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C: Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 1999;276:R136-R142.
17. Finck BN, Kelley KW, Dantzer R, Johnson RW: In vivo and in vitro evidence for the involvement of tumor necrosis factor-alpha in the induction of leptin by lipopolysaccharide. Endocrinology 1998;139:2278-2283.
18. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM: Leptin regulates proinflammatory immune responses FASEB J 1998;12:57-65.
19. Takahashi N, Waelput W, Guisez Y: Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 1999;189:207-212.
20. Bartness TJ, Powers JB, Hastings MH, Bittman EL, Goldman BD: The timed infusion paradigm for melatonin delivery: What has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses? J Pineal Res 1993;15:161-190.
21. Goldman BD: The Siberian hamster as a model for study of the mammalian photoperiodic mechanism. Adv Exp Med Biol 1999;460:155-164.
22. Demas GE, Drazen DL, Jasnow AM, Bartness TJ, Nelson RJ: Sympathoadrenal system differentially affects photoperiodic changes in immune function in Siberian hamsters (Phodopus sungorus). J Neuroendocrinol 2002;14:29-35.
23. Drazen DL, Kriegsfeld LJ, Schneider JE, Nelson RJ: Leptin, but not immune function, is linked to reproductive responsiveness to photoperiod. Am J Physiol 2000;278:R1401-R1407.
24. Yellon SM, Fagoaga OR, Nehlsen-Cannarella SL: Influence of photoperiod on immune cell functions in the male Siberian hamster. Am J Physiol 1999;276:R97-R102.
25. Okamoto S, Irie Y, Ishikawa I, Kimura K, Saito M: Central leptin suppresses lymphocyte functions through activation of the corticotrophin-releasing hormone-sympathetic nervous system. Brain Res 2000;855:192-197.
26. Williams JM, Peterson RG, Shea PA, Schmedtje JF, Bauer DC, Felten DL: Sympathetic innervation of murine thymus and spleen: Evidence for a functional link between the nervous and immune systems. Brain Res Bull 1981;6:83-94.
27. Dixon FJ, Jacot-Guillarmod H, McConahey PJ: The antibody responses of rabbits and rats to hemacyanin. J Immunol 1966;97:350-355.
28. Bilbo SD, Drazen DL, Quan N, He L, Nelson RJ: Short day lengths attenuate the symptoms of infection in Siberian hamsters. Proc Roy Soc Lond [B] 2001;269:447-454.
29. Bellinger DL, Lorton D, Luhahn C, Felten DL: Innervation of lymphoid organs: Association of nerves with cells of the immune system and their implications in disease; in Ader R, Felten DL, Cohen N (eds): Psychoneuroimmunology, ed 3. New York, Academic Press, 2001, pp 55-111.
30. Sanders VM, Kasprowicz DH, Kohm AP, Swanson MA: Neurotransmitter receptors on lymphocytes and other lymphoid tissues; in Ader R, Felten DL, Cohen N (eds): Psychoneuroimmunology, ed 3. New York, Academic Press, 2001, pp 161-196.
31. Miles K, Quintans, J Chelmicka-Schorr E, Arnason BG: The sympathetic nervous system modulates antibody response to thymus-independent antigens. J Neuroimmunol 1981;1:101-105.
32. Depelchin A, Letesson JJ: Adrenaline influence on the immune response. I. Accelerating or suppressor effects according to the time of applications. Immunol Lett 1981;3:199-205.
33. Kruszewska B, Felten DL, Stevens SY, Moynihan JA: Sympathectomy-induced immune changes are not abrogated by the glucocorticoid receptor blocker RU-486. Brain Behav Immunol 1998;12:181-200.
34. Kohm AP, Sanders VM: Norepinephrine: A messenger from the brain to the immune system. Immunol Today 2000;21:539-542.
35. Livnat S, Felten SY, Carlson SL, Bellinger DL, Felten DL: Involvement of peripheral and central catecholamine systems in neural-immune interactions. J Neuroimmunol 1985;10:5-30.
36. Fuchs BA, Albright JW, Albright JF: β-Adrenergic receptors on murine lymphocytes: Density varies with cell maturity and lymphocyte subtype and is decreased after antigen administration. Cell Immunol 1988;114:231-245.
37. Elenkov IJ, Wilder RJ, Chrousos GP, Vizi ES: The sympathetic nerve: An integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev 2000;52:595-638.
38. Blalock JE: The immune system as a sensory organ. J Immunol 1984;132:1067-1070.