Comparison of SXT and R391, two conjugative integrating elements: Definition of a genetic backbone for the mobilization of resistance determinants

Cellular and Molecular Life Sciences

Volumn 59, Issue 12, 2002, Pages 2065-2070

  Beaber, J W ^a   Burrus, V ^a   Hochhut, B ^a   Waldor, M K ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Comparative genomics; Conjugative transposon; Gene transfer; R391; SXT; Vibrio cholerae

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL DNA;

ANTIBIOTIC RESISTANCE; BACTERIAL GENE; DNA FLANKING REGION; DNA SEQUENCE; DNA STRUCTURE; DNA VECTOR; GENE DELETION; GENE FUNCTION; GENE IDENTIFICATION; GENE INSERTION; GENE LOCUS; GENE REPLICATION; HOST; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROVIDENCIA; R391 GENE; REVIEW; SEQUENCE ANALYSIS; SXT GENE; TRANSPOSON; VIBRIO CHOLERAE;

BASE SEQUENCE; CONJUGATION, GENETIC; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; GENE TRANSFER, HORIZONTAL; GENES, BACTERIAL; PLASMIDS; RETROELEMENTS; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); INSERTION SEQUENCES; NEGIBACTERIA; PROVIDENCIA; PROVIDENCIA RETTGERI; TRANSPOSONS; VIBRIO; VIBRIO CHOLERAE;

EID: 0036966973     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180200006     Document Type: Review

References (29)

1. Cholera Working Group (1993) Large epidemic of cholera-like disease in Bangladesh caused by Vibrio cholerae O139 synonym Bengal. International Centre for Diarrhoeal Diseases Research, Bangladesh. Lancet 342: 387-390
2. Waldor M. K., Tschape H. and Mekalanos J. J. (1996) A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim and streptomycin in Vibrio cholerae O139. J. Bacteriol. 178: 4157-4165
3. th Joint Conference U.S. - Japan Cooperative Medical Science Program Cholera and Related Diarrheal Diseases Panel, Fukuoka, Japan
4. Hochhut B. and Waldor M. K. (1999) Site-specific integration of the conjugal Vibrio cholerae SXT element into prfC. Mol. Microbiol. 32: 99-110
5. Mukhopadhyay A. K., Basu A., Garg P., Bag P. K., Ghosh A., Bhattacharya S. K. et al. (1998) Molecular epidemiology of reemergent Vibrio cholerae O139 Bengal in India. J. Clin. Microbiol. 36: 2149-2152
6. Hochhut B., Lotfi Y., Mazel D., Faruque S. M., Woodgate R. and Waldor M. K. (2001) Molecular analysis of the antibiotic resistance gene clusters in the Vibrio cholerae O139 and O1 SXT constins. Antimicrob. Agents Chemother. 45: 2991-3000
7. Dalsgaard A., Forslund A., Sandvang D., Arntzen L. and Keddy K. (2001) Vibrio cholerae O1 outbreak isolates in Mozambique and South Africa in 1998 are multiple-drug resistant, contain the SXT element and the aadA2 gene located on class 1 integrons. J. Antimicrob. Chemother. 48: 827-838
8. Hochhut B., Beaber J. W., Woodgate R. and Waldor M. K. (2001) Formation of chromosomal tandem arrays of the SXT element and R391, two conjugative chromosomally integrating elements that share an attachment site. J. Bacteriol. 183: 1124-1132
9. Ho C., Kulaeva O. I., Levine A. S. and Woodgate R. (1993) A rapid method for cloning mutagenic DNA repair genes: isolation of umu-complementing genes from multidrug resistance plasmids R391, R446b and R471 a. J. Bacteriol. 175: 5411-5419
10. Pembroke J. T. and Murphy D. B. (2000) Isolation and analysis of a circular form of the IncJ conjugative transposon-like elements, R391 and R997: implications for IncJ incompatibility. FEMS Microbiol. Lett. 187: 133-138
11. Nugent M. (1981) A conjugative 'plasmid' lacking autonomous replication. J. Gen. Microbiol. 126: 305-310
12. Murphy D. B. and Pembroke J. T. (1995) Transfer of the IncJ plasmid R391 to recombination deficient Escherichia coli K12: evidence that R391 behaves as a conjugal transposon. FEMS Microbiol. Lett. 134: 153-158
13. Coetzee J. N., Datta N. and Hedges R. W. (1972) R factors from Proteus rettgeri. J. Gen. Micro. 72: 543-552
14. Yokota T. and Kuwahari S. (1977) Temperature sensitive R plasmid obtained from naturally isolated drug-resistant Vibrio cholera (biotype El Tor). Antimicrob. Agents Chemother. 11: 13-20
15. Matthews M., Hedges R. W. and Smith J. T. (1979) Types of β-lactamase determined by plasmids in Gram-negative bacteria. J. Bacteriol. 138: 657-704
16. Hedges R. W. (1974) R factors from Providence. J. Gen. Microbiol. 181: 171-181
17. Figueroa-Bossi N. and Bossi L. (1999) Inducible prophages contribute to Salmonella virulence in mice. Mol. Microbiol. 33: 167-176
18. Zhao S. and Williams K. P. (2002) Integrative genetic element that reverses the usual target gene orientation. J. Bacteriol. 184: 859-860
19. Murphy D. B. and Pembroke J. T. (1999) Monitoring of chromosomal insertions of the IncJ elements R391 and R997 in Escherichia coli K-12. FEMS Microbiol. Lett. 174: 355-361
20. Beaber J. W., Hochhut B. and Waldor, M. K. (2002) Genomic and functional analyses of SXT an integrating antibiotic resistance gene transfer element derived from Vibrio cholerae. J. Bacteriol. 184: 4259-4269
21. Boeltner D., MacMahon C., Pembroke J. T., Strike P. and Osborn A. M. (2002) R391: a conjugative integrating mosaic comprised of phage, plasmid and transposon elements. J. Bacteriol. 184: 5158-5169
22. Bradley D. E. (1980) Determination of pili by conjugative bacterial drug resistance plasmids of incompatibility groups B, C, H, J, K, M, V and X. J. Bacteriol. 141: 828-837
23. Hochhut B., Marrero J. and Waldor M. K. (2000) Mobilization of plasmids and chromosomal DNA mediated by the SXT element, a constin found in Vibrio cholerae O139. J. Bacteriol. 182: 2043-2047
24. Hedges R. W., Jacob A. E., Datta N. and Coetzee J. N. (1975) Properties of plasmids produced by recombination between factors of group J and FII. Mol. Gen. Genet. 140: 289-302
25. Peters S. E., Hobman J. L., Strike P. and Ritchie, D. A. (1991) Novel mercury resistance determinants carried by IncJ plasmids pMERPH and R391. Mol. Gen. Genet. 228: 294-299
26. Sherburne C. K., Lawley T. D., Gilmour M. W., Blattner F. R., Burland V., Grotbeck E. et al. (2000) The complete DNA sequence and analysis of R27, a large IncHI plasmid from Salmonella typhi that is temperature sensitive for transfer. Nucleic Acids Res. 28: 2177-2186
27. Romine M. F., Stillwell L. C., Wong K. K., Thurston S. J., Sisk E. C., Sensen C. et al. (1999) Complete sequence of a 184-kilo-base catabolic plasmid from Sphingomonas aromaticivorans F199. J. Bacteriol. 181: 1585-1602
28. Murata T, Ohnishi M., Ara T., Kaneko J., Han C. G., Li Y. F. et al. (2002) Complete nucleotide sequence of plasmid Rts1: implications for evolution of large plasmid genomes. J. Bacteriol. 184: 3194-3202
29. Ruvolo P. P., Keating K. M., Williams K. R. and Chase J. W. (1991) Single-stranded DNA binding proteins (SSBs) from prokaryotic transmissible plasmids. Proteins 9: 120-134