Rho-kinase inhibitors: Pharmacomodulations on the lead compound Y-32885

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 17, Issue 6, 2002, Pages 381-390

  Logé, Cédric ^a   Wallez, Valérie ^a   Scalbert, Elizabeth ^b   Cario Tourmaniantz, Christelle ^c   Loirand, Gervaise ^c   Pacaud, Pierre ^c   Lesieur, Daniel ^a  

^a Laboratoire de Physique   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c INSERM   (France)

Author keywords

Contraction; Inhibitors; Rho kinase; Smooth muscle; Structure activity relationships; Y 32885

Indexed keywords

ACTIN; BENZAMIDE DERIVATIVE; ENZYME INHIBITOR; N (4 PYRIDYL) 4 (1 AMINOETHYL)BENZAMIDE; RHO KINASE; UNCLASSIFIED DRUG; Y 32885;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION;

ACTINS; ANIMALS; AORTA; BENZAMIDES; ENZYME INHIBITORS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PERMEABILITY; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0036957215     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636021000005659     Document Type: Article

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