Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy

Gene Therapy

Volumn 9, Issue 24, 2002, Pages 1653-1658

  Miura, F ^a,b   Moriuchi, S ^a   Maeda, M ^c   Sano, A ^d   Maruno, M ^a   Tsanaclis, A M ^b   Marino Jr , R ^b   Glorioso, J C ^e   Yoshimine, T ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c OSAKA NATIONAL HOSPITAL   (Japan)

^d DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Drug delivery system; Ganciclovir; Gene therapy; Glioma; Herpes simplex virus; Silicone

Indexed keywords

GANCICLOVIR; SILICONE; THYMIDINE KINASE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG POTENTIATION; DRUG SAFETY; DRUG TISSUE LEVEL; GENE EXPRESSION; GLIOSARCOMA; HERPES SIMPLEX VIRUS 1; HISTOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SUICIDE GENE; SUICIDE GENE THERAPY; SURVIVAL TIME; SUSTAINED RELEASE PREPARATION;

ANIMALS; ANTIVIRAL AGENTS; BRAIN NEOPLASMS; BYSTANDER EFFECT; CAUDATE NUCLEUS; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; FEMALE; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; GLIOSARCOMA; HERPESVIRUS 1, HUMAN; INJECTIONS, INTRALESIONAL; INJECTIONS, INTRAPERITONEAL; MODELS, ANIMAL; RATS; RATS, INBRED F344; SILICONES; SURVIVAL RATE; THYMIDINE KINASE;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0036954249     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301860     Document Type: Review

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