Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom

International Journal of Colorectal Disease

Volumn 17, Issue 4, 2002, Pages 259-267

  Christie, Angela ^a   Guest, Julian F ^a  

^a CATALYST Health Economics Consultants   (United Kingdom)

Author keywords

Anal fissure; Costs; Lateral internal sphincterotomy; Nitroglycerin; Rectogesic

Indexed keywords

BOTULINUM TOXIN; DILTIAZEM; GLYCERYL TRINITRATE;

ANUS FISSURE; ANUS SURGERY; ARTICLE; CHRONIC DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; COST CONTROL; COST EFFECTIVENESS ANALYSIS; DISEASE MODEL; DRUG FORMULATION; GENERAL PRACTITIONER; HEALTH ECONOMICS; HUMAN; INTERVIEW; MEDICAL DECISION MAKING; NATIONAL HEALTH SERVICE; OUTCOMES RESEARCH; PATIENT CARE; PRIORITY JOURNAL; RESOURCE MANAGEMENT; SURGEON; TREATMENT OUTCOME; UNITED KINGDOM;

ANAL CANAL; COST CONTROL; DECISION TREES; FISSURE IN ANO; GREAT BRITAIN; HEALTH CARE COSTS; HEALTH RESOURCES; HUMANS; MODELS, ECONOMIC; NITROGLYCERIN; STATE MEDICINE; VASODILATOR AGENTS;

EID: 0036943862     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-001-0371-6     Document Type: Article

References (48)

1. Lund JN, Scholefield JH (1997) A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 349:11-14
2. Carapeti EA, Kamm MA, McDonald PJ, et al (1999) Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. Gut 44:727-730
3. Bacher H, Mischinger H-J, Werkgartner G, et al (1997) Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 40:840-845
4. Dorfman G, Levitt M, Platell C (1999) Treatment of chronic anal fissure with topical glyceryl trinitrate. Dis Colon Rectum 42:1007-1010
5. Jonas M, Lobo DN, Gudgeon AM (1999) Lateral internal sphincterotomy is not redundant in the era of glyceryl trinitrate therapy for chronic anal fissure. J R Soc Med 92:186-188
6. Chase D, Milne R (1999) Glyceryl trinitrate for chronic anal fissures. Southampton: Wessex Institute for Health Research and Development; March. Development and Evaluation Committee report, no 96
7. Hyman NH, Cataldo PA (1999) Nitroglycerin ointment for anal fissures. Dis Colon Rectum 42:383-385
8. Kennedy ML, Sowter S, Nguyen H, et al (1999) Glyceryl trinitrate ointment for the treatment of chronic anal fissure. Dis Colon Rectum 42:1000-1006
9. Jonas M, Lund JN, Amin S, et al (2000) Topical glyceryl trinitrate (GTN) for anal fissures in clinical practice: long-term efficacy. Colorectal Dis 2 [Suppl 1]:15
10. Oettlé GJ (1997) Glyceryl trinitrate vs sphincterotomy for treatment of chronic fissure-in-ano. Dis Colon Rectum 40:1318-1320
11. Pernikoff BJ, Eisenstat TE, Rubin RJ, et al (1994) Reappraisal of partial lateral internal sphincterotomy. Dis Colon Rectum 37:1291-1295
12. Nyam DCNK, Pemberton JH (1999) Long-term results of lateral internal sphincterotomy for chronic anal fissure with particular reference to incidence of fecal incontinence. Dis Colon Rectum 42:1306-1310
13. Walker WA, Rothenberger DA, Goldberg SM (1985) Morbidity of internal sphincterotomy for anal fissure and stenosis. Dis Colon Rectum 28:832-835
14. Sharp FR (1996) Patient selection and treatment modalities for chronic anal fissure. Am J Surg 171:512-515
15. Leong AFPK, Seow-Choen F (1995) Lateral sphincterotomy compared with anal advancement flap for chronic anal fissure. Dis Colon Rectum 38:69-71
16. Hananel N, Gordon PH (1997) Lateral internal sphincterotomy for fissure-in-ano revisited. Dis Colon Rectum 40:597-602
17. Usattoff V, Polglase AL (1995) The longer term results of internal anal sphincterotomy for anal fissure. Aust N Z J Surg 65:576-578
18. Changyul O, Divino CM, Steinhagen RM (1995) Anal fissure: 20-year experience. Dis Colon Rectum 38:378-382
19. Schouten WR, Briel JW, Auwerda JJ, et al (1996) Anal fissure: new concepts in pathogenesis and treatment. Scand J Gastroenterol Suppl 218:78-81
20. Littlejohn DRG, Newstead GL (1997) Tailored lateral sphincterotomy for anal fissure. Dis Colon Rectum 40:1439-1442
21. Ŝimkovic D, Ŝiroký M, Ŝmejkal K (1997) The chronic anal fissure treatment by internal partial lateral sphincterotomy and following anal manometry. Acta Med (Hradec Králové) 40:13-15
22. Farouk R, Duthie GS, Gunn J (1998) Changing patterns of treatment for chronic anal fissure. Ann R Coll Surg Engl 80:194-196
23. Department of Health (1999) The new NHS 1999 reference costs. Department of Health, London
24. Bruce NJ, McCloskey EV, Kanis JA, et al (1999) Economic impact of using clodronate in the management of patients with multiple myeloma. Br J Haematol 104:358-364
25. Haymarket Publishing Services (2000) Monthly index of medical specialities 2000 editions. Haymarket Medical, London
26. Netten A, Dennett J, Knight J (1999) Unit costs of health and social care. Personal Social Services Research Unit, University of Kent, Canterbury
27. Flynn TN, Kelsey SM, Hazel DL, et al (1999) Cost-effectiveness of amphotericin B plus G-CSF compared with amphotericin B monotherapy treatment of presumed deep-seated fungal infection in neutropenic patients in the UK. Pharmacoeconomics 16:543-550
28. The Treasury (1997) Annex G: the cost of capital discounts and required rate of return. In: Appraisal and evaluation in central government. HMSO, London
29. Corman ML (1998) Anal fissure. In: Corman ML (ed) Colon and rectal surgery. Lippincott-Raven, New York, pp 206-223
30. Brisinda G, Maria G, Bentivoglio A, et al (1999) A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med 341:65-69
31. Altomare DF, Rinaldi M, Milito G, et al (2000) Glyceryl trinitrate for chronic anal fissure-healing or headache? Results of a multicenter, randomized, placebo-controlled, double-blind trial. Dis Colon Rectum 43:174-179
32. Hasegawa H, Radley S, Morton DG, et al (2000) Audit of topical glyceryl trinitrate for treatment of fissure-in-ano. Ann R Coll Surg Engl 82:27-30
33. Jost WH, Schimrigk K (1994) Therapy of anal fissure using botulinum toxin. Dis Colon Rectum 37:1321-1324
34. Maria G, Cassetta E, Gui D, et al (1998) A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 338:217-220
35. Maria G, Brisinda G, Bentivoglio AR, et al (1998) Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure: long-term results after two different dosage regimens. Ann Surg 228:664-669
36. Maria G, Brisinda G, Bentivoglio AR, et al (2000) Influence of botulinum toxin site of injections on healing rate in patients with chronic anal fissure. Am J Surg 179:46-50
37. Department of Health (2001) Hospital episode statistics 1999-2000. Department of Health, London
38. Bhardwaj R, Vaizey C, Boulos P (2000) Topical 2% diltiazem in the treatment of chronic anal fissure. Colorectal Dis 2 [Suppl 1]:16
39. Khubchandani IT, Reed JF (1989) Sequelae of internal sphincterotomy for chronic fissure in ano. Br J Surg 76:431-434
40. Hoffman D, Goligher J (1970) Lateral subcutaneous internal sphincterotomy in treatment of anal fissure. BMJ 3:673-675
41. Notaras MJ (1971) The treatment of anal fissure by lateral subcutaneous internal sphincterotomy - a technique and results. Br J Surg 58:96-100
42. Bailey RV, Rubin RJ, Salvati EP (1978) Lateral internal sphincterotomy. Dis Colon Rectum 21:584-586
43. Vafai M, Mann C (1981) Closed lateral internal sphincterotomy without removal of sentinel pile for fissure-in-ano. Coloproctology 3:91-93
44. Gordon PH, Vasilevsky CA (1985) Symposium on outpatient anorectal procedures. Lateral internal sphincterotomy rationale, technique and anesthesia. Can J Surg 28:228-230
45. Lewis TH, Corman ML, Prager ED, et al (1988) Long-term results of open and closed sphincterotomy for anal fissure. Dis Colon Rectum 31:368-371
46. Garcia-Aguilar J, Belmonte C, Wong WD, et al (1996) Open vs. closed sphincterotomy for chronic anal fissure: long-term results. Dis Colon Rectum 39:440-443
47. Kamm MA (1998) Diagnostic, pharmacological, surgical and behavioural developments in benign anorectal disease. Eur J Surg Suppl 582:119-123
48. Oliver DW, Booth MWC, Kernick VFM, et al (1998) Patient satisfaction and symptom relief after anal dilatation. Int J Colorectal Dis 13:228-231