Treatment of chronic anal fissure with topical glyceryl trinitrate

Diseases of the Colon and Rectum

Volumn 42, Issue 8, 1999, Pages 1007-1010

  Dorfman, Grigori ^a,b   Levitt, Michael ^a,b   Platell, Cameron ^a,b  

^a FREMANTLE HOSPITAL   (Australia)

^b NONE

Author keywords

Anal fissure; Glyceryl trinitrate

Indexed keywords

GLYCERYL TRINITRATE;

ADULT; AGED; ANUS FISSURE; ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; HEADACHE; HUMAN; PATIENT COMPLIANCE; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; VERTIGO; WOUND HEALING;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; CHRONIC DISEASE; FEMALE; FISSURE IN ANO; HUMANS; MALE; MIDDLE AGED; NITROGLYCERIN; PATIENT COMPLIANCE; PATIENT SATISFACTION; RECURRENCE; RETROSPECTIVE STUDIES; VASODILATOR AGENTS;

EID: 0032838022     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02236692     Document Type: Article

References (17)

1. Madoff R. Pharmacological therapy for anal fissure. N Engl J Med 1998;338:257-9.
2. Farouk R, Duthie GS, MacGregor AB, Bartolo DC. Sustained internal sphincter hypertonia in patients with chronic anal fissure. Dis Colon Rectum 1994;37:424-9.
3. Scheuten WR, Briel JW, Auwerda JJ. Relationship between anal pressure and the anodermal blood flow: the vascular pathogenesis of anal fissures. Dis Colon Rectum 1994;37:664-9.
4. Pernikoff BJ, Eisenstat TE, Rubin RJ, Oliver GC, Salvati EP. Reappraisal of partial lateral internal sphincterotomy. Dis Colon Rectum 1994;37:1291-5.
5. Khubchandani I, Reed J, Sequelae of internal sphincterotomy for chronic fissure in ano. Br J Surg 1989;76:431-4.
6. Maria G, Cassetta E, Gui D, Brisinda G, Bentivoglio A, Albanese A. A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 1998;338:217-20.
7. Lund J, Scholefield J. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997;349:11-4.
8. Bacher H, Mischinger H, Werkgartner G, et al. Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 1997;40:840-5.
9. Lund JN, Scholefield JH. Glyeryl trinitrate is an effective treatment for anal fissure. Dis Colon Rectum 1997;40:468-70.
10. Watson S, Kamm M, Nicholls R, Phillips R. Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 1996;83:771-5.
11. Gorfine S. Topical nitroglycerin therapy for anal fissures and ulcers. N Engl J Med 1995;333:1156-7.
12. Scheuten W, Briel J, Boerma M, Auwerda J, Wilms E, Graatsma B. Pathophysiological aspect and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure. Gut 1996;39:465-9.
13. Banerjee A. Treating anal fissure: glyceryl trinitrate ointment may remove the need for surgery. BMJ 1997;314:1638-9.
14. Gorfine S. Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum 1995;38:453-7.
15. Jost W. One hundred cases of anal fissure treated with botulin toxin: early and long-term results. Dis Colon Rectum 1997;40:1029-32.
16. Herxheimer A. Glyceryl trinitrate ointment for chronic anal fissure [letter; comment]. Lancet 1997;349:573.
17. O'Kelly T, Grading A, Mortensen N. Nerve mediated relaxation of the human internal anal sphincter: the role of nitric oxide. Gut 1993;34:689-93.