Chronic lymphocytic leukaemia: One disease or two?

Annals of Hematology

Volumn 81, Issue 6, 2002, Pages 299-303

  Hamblin, T ^a  

^a ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

Author keywords

CD38; Chronic lymphocytic leukemia; Immunoglobulin VH genes; p53; Prognostic factors

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD38 ANTIGEN;

ANTIGEN EXPRESSION; APOPTOSIS; B LYMPHOCYTE; BENIGN TUMOR; CHROMOSOME ABERRATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GERMINAL CENTER; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALIGNANT NEOPLASTIC DISEASE; MORPHOLOGY; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; TUMOR CLASSIFICATION;

LEUKEMIA, LYMPHOCYTIC, CHRONIC;

EID: 0036942874     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-002-0476-1     Document Type: Review

References (44)

1. Kuppers R, Sousa AB, Baur AS, Strickler JG, Rajewsky K, Hausmann ML (2001) Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL. Mol Med 7:285-292
2. Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) The World Health Organization classification of tumours: tumours of haematopoietic and lymphoid tissues. WHO, Geneva
3. Melo JV (1996) The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 88: 2375-2384
4. Galton DAG (1966) The pathogenesis of chronic lymphocytic leukaemia. Can Med Assoc J 94:1005-1010
5. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1989) French-American-British (FAB) Cooperative Group. Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. J Clin Pathol 42: 567-584
6. Moreau EJ, Matutes E, A'Hern RP, Morilla AM, Morilla RM, Owusu-Ankomah KA, Seon BK, Catovsky D (1997) Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). Am J Clin Pathol 108: 378-382
7. Juliusson G, Oscier DG, Fitchett M, Ross FM, Stockdill G, Mackie MJ, Parker AC, Castoldi GL, Guneo A, Knuutila S (1990) Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 323:720-724
8. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94: 1848-1854
9. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, Buchbinder A, Budman D, Dittmar K, Kolitz J. Lichtman SM, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1840-1847
10. Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302:575-581
11. Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J (1992) VDJ recombination. Immunol Today 13:306-314
12. Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D (1984) Insertion of N regions into heavy chain genes is correlated with the expression of terminal deoxytransferase in B cells. Nature 311:752-755
13. Corbett SJ, Tomlinson IM, Sonnhammer EL, Buck D, Winter G (1997) Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol 270:587-597
14. MacLennan IC (1994) Germinal centers. Annu Rev Immunol 12:117-139
15. Stevenson F, Sahota S, Zhu D, Ottensmeier C, Chapman C, Oscier D, Hamblin T (1998) Insight into the origin and clonal history of B-cell tumours as revealed by immunoglobulin variable region gene analysis. Immunol Rev 162:247-259
16. Zhu D, McCarthy H, Ottensmeier CH, Johnson P, Hamblin TJ, Stevenson FK (2002) Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood 99: 2562-2568
17. Kipps TJ, Tomhave E, Pratt LF, Duffey S, Chen PP, Carson DA (1989) Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 86:5913-5917
18. H1 genes in human B-lineage leukaemias. Leukemia 5:646-650
19. Ebeling SB, Schutte MEM, Akkermans-Koolhaas KE, Bloem AC, Gmelig-Meyling FHJ, Logtenberg T (1992) Expression of members of the immunoglobulin VH-3 gene families is not restricted at the level of individual genes in human chronic lymphocytic leukemia. Int Immunol 4:313-320
20. Schroeder HW Jr, Dighiero G (1994) The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today 15:288-294
21. Fais F, Ghiotto F, Hashimoto S, Sellers B, Valetto A, Schulman P, Vinciguerra VP, Rai K, Rassenti LZ, Kipps TJ, Dighiero G, Schroeder HW Jr, Ferrarini M, Chiorazzi N (1998) Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 102:1515-1525
22. Oscier DG, Thompsett A, Zhu D, Stevenson FK (1997) Differential rates of somatic hypermutation in VH genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood 89:4153-4160
23. Maloum K, Davi F, Merle-Beral H, Pritsch O, Magnac C, Vuillier F, Dighiero G, Troussard X, Mauro FF, Benichou J (2000) Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia. Blood 95:377-378
24. Kroeber A, Seiler T, Leupolt E, Dohner H, Stilgenbauer S (2000) IgVH mutated and unmutated B-CLL tumors show distinct genetic aberration patterns (abstract). Blood 96:3609a
25. Bahler DW, Aguilera NS, Chen CC, Abbondanzo SL, Swerdlow SH (2000) Histological and immunoglobulin VH gene analysis of interfollicular small lymphocytic lymphoma provides evidence for two types. Am J Pathol 157:1063-1070
26. H3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 99:2262-2264
27. Hamblin TJ, Orchard JA, Ibbotson RE, Davies Z, Thomas PW, Stevenson FK, Oscier DG (2002) CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 99:1023-1029
28. Bauvois B, Durant L, Laboureau J, Barthelemy E, Rouillard D, Boulla G, Deterre P (1999) Upregulation of CD38 gene expression in leukemic B cells by interferon types I and II. J Interferon Cytokine Res 19:1059-1066
29. Oscier DG, Gardiner AC, Mould SJ, Glide S, Davies Z, Ibbotson RE, Corcoran MM, Chapman RM, Thomas PW, Copplestone JA, Orchard JA, Hamblin TJ (2002) Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood, in press
30. Johnson TA, Rassenti LZ, Kipps TJ (1997) VH1 genes expressed in B cell chronic lymphocytic leukemia exhibits distinctive molecular features. J Immunol 158:235-246
31. Rosenquist R, Lindstrom A, Holmberg D, Lindh J, Roos G (1999) V(H) gene family utilization in different B-cell lymphoma subgroups. Eur J Hematol 62:123-128
32. Brezinschek HP, Brezinschek RI, Dorner T, Lipsky PE (1998) Similar characteristics of the CDR3 of V(H)1-69/DP-10 rearrangements in normal human peripheral blood and chronic lymphocytic leukaemia blood cells. Br J Haematol 102: 516-521
33. Chen PP, Liu MF, Glass CA, Sinha S, Kipps TJ, Carson DA (1989) Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors. Arthritis Rheum 32:72-78
34. H 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J Mol Biol 256:577-589
35. H3-21 B cells escape from a state of tolerance in rheumatoid arthritis and secrete rheumatoid factor. Mol Med 1:768-780
36. Pritsch O, Magnac C, Dumas G, Egile C, Dighiero G (1993) V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity. Blood 82:3103-3112
37. Rosenwald A, Alizadeh AA, Widhopf G. Simon R, Davis RE, Yu X, Yang L, Pickeral OK, Rassenti LZ, Powell J, Botstein D, Byrd JC, Grever MR, Cheson BD, Chiorazzi N, Wilson WH, Kipps TJ, Brown PO, Staudt LM (2001) Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 194: 1639-1647
38. Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, Husson H, Freedman A, Inghirami G, Cro L, Baldini L, Neri A, Califano A, Dalla-Favera R. (2001) Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 194: 1625-1638
39. Klein U, Rajewsky K, Kuppers R (1998) Human immunoglobulin (Ig)M+ IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 188:1679-1689
40. Caligaris-Cappio F, Hamblin TJ (1999) B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol 17:399-408
41. Stankovic T, Stewart GS, Fegan C, Biggs P, Last J, Byrd PJ, Keenan RD, Moss PA, Taylor AM (2002) Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage. Blood 99: 300-309
42. Leupolt E, Stilgenbauer S, Krober A, Bullinger L, Lichter P, Dohner H (2001) Clonal evolution in B-CLL: acquisitions of deletions involving 6q21, 11q22, and 17p13 (TP53) associated with disease progression. Blood 98 [Suppl 1]:471a
43. Orchard JA, Oscier DG (1996) Prognostic value of Ki 67 and cell cycle analysis in chronic lymphocytic leukaemia. Br J Haematol 93 [Suppl 2]:116
44. H gene mutation status in chronic lymphocytic leukemia.