Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high-dose antigen therapy in experimental autoimmune encephalomyelitis

Acta Neuropathologica

Volumn 104, Issue 4, 2002, Pages 385-390

  Weishaupt, Andreas ^a   Kuhlmann, Tanja ^b   Schönrock, Lisa M ^a,c   Toyka, Klaus V ^a   Brück, Wolfgang ^b   Gold, Ralf ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Antigen therapy; Apoptosis; Intravenous immunoglobin; Multiple sclerois

Indexed keywords

ALBUMIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOMODULATING AGENT; LIVER ENZYME; MYELIN BASIC PROTEIN; POLYCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL TISSUE; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; ENZYME BLOOD LEVEL; FEMALE; GLIA CELL; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LIVER CELL; LIVER INJURY; LIVER PROTECTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; RAT; SPINAL CORD; T LYMPHOCYTE; TISSUE SPECIFICITY;

EID: 0036942283     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-002-0568-y     Document Type: Article

References (29)

1. Zamvil SS, Steinman L (1990) The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 8:579-621
2. Gold R, Hartung HP, Toyka KV (2000) Animal models for autoimmune demyelinating disorders of the nervous system. Med Mol Today 6:88-91
3. Wekerle H (1993) Experimental autoimmune encephalomyelitis as a model of immune-mediated CNS disease. Curr Opin Neurobiol 3:779-784
4. Weishaupt A, Jander S, Brück W, Kuhlmann T, Stienekemeier M, Hartung T, Toyka KV, Stoll G, Gold R (2000) Molecular mechanisms of high-dose antigen therapy in experimental autoimmune encephalomyelitis: rapid induction of Th1-type cytokines and inducible nitric oxide synthase. J Immunol 165: 7157-7163
5. Jones AL, Selby P (1989) Tumor necrosis factor: clinical relevance. Cancer Surv 8:817-836
6. Leist M, Gantner F, Jilg S, Wendel A (1996) Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J Immunol 154:1307-1316
7. Weishaupt A, Gold R, Hartung T, Gaupp S, Wendel A, Brück W, Toyka KV (2000) Role of TNF-α in high dose antigen therapy in experimental autoimmune neuritis: inhibition of TNF-α by neutralizing antibodies reduces T-cell apoptosis and prevents liver necrosis. J Neuropathol Exp Neurol 59:368-376
8. Kleyweg RP, Meche FG van der, Meulstee J (1988) Treatment of Guillain-Barré syndrome with high-dose gammaglobulin. Neurology 38:1639-1641
9. Van Doorn PA, Brand A, Stengers PF, Meulstee J, Vermeulen M (1990) High-dose intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: a double-blind, placebo-controlled, crossover study. Neurology 40:209-212
10. Achiron A, Gabbay U, Gilad R, Hassin-Baer S, Barak Y, Gornish M, Elizur A, Goldhammer Y, Sarova-Pinhas I (1998) Intravenous immunoglobulin treatment in multiple sclerosis. Effect on relapses. Neurology 50:398-402
11. Fazekas F, Deisenhammer F, Strasser-Fuchs S, Nahler G, Mamoli B (1997) Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis. Lancet 349:589-593
12. Sorensen PS, Wanscher B, Jensen CV, Schreiber K, Blinkenberg M, Ravnborg M, Kirsmeier H, Larsen VA, Lee ML (1998) Intravenous immunoglobulin G reduces MRI activity in relapsing multiple sclerosis. Neurology 50:1273-1281
13. Stangel M, Hartung HP, Marx P, Gold R (1998) Intravenous immunoglobulin treatment of neurological autoimmune diseases. J Neurol Sci 153:203-214
14. Kazatchkine MD, Kaveri SV (2001) Immunmodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 345:747-755
15. Achiron A, Margalit R, Hershkoviz R, Markovits D, Reshef T, Melamed E, Cohen IR, Lider O (1994) Intravenous immunoglobulin treatment of experimental T cell-mediated autoimmune disease. J Clin Invest 93:600-605
16. Stangel M, Compston A (2001) Polyclonal immunglobulin (IVIg) modulate nitric oxide production and microglial functions in vitro via Fc receptor. J Neuroimmunol 112:65-71
17. Gold R, Giegerich G, Hartung,HP, Toyka KV (1995) T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR β-chain-variable-region Vβ8.2-positive T cells are not essential for induction and course of disease. Proc Natl Acad Sci USA 92:5850-5854
18. Bergmeyer HU (1984) Methods of enzymatic analysis, vol 82, 3rd edn. Verlag Chemie, Weinheim
19. Eylar EH, Kniskern PJ, Jackson JJ (1974) Myelin basic proteins. Methods Enzymol 3213:323-341
20. Zettl UK, Gold R, Toyka KV, Hartung HP (1995) Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat. J Neuropathol Exp Neurol 54:540-547
21. Piddlesden SJ, Lassmann H, Zimprich F, Morgan BP, Linington C (1993) The demyclinating potential of antibodies to myelin oligidendrocyte glycoprotein is related to their ability to fix complement. Am J Pathol 145:555-564
22. Gold R, Schmied M, Giegerich G, Breitschopf H, Hartung HP, Toyka KV, Lassmann H (1994) Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation technique. Lab Invest 71:219-225
23. Bursch W, Kleine L, Tenniswood M (1990) The biochemistry of cell death by apoptosis. Biochem Cell Biol 68:1071-1074
24. Weishaupt A, Gold R, Gaupp S, Giegerich G, Hartung HP, Toyka KV (1997) Antigen therapy eliminates T cell inflammation by apoptosis: effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Proc Natl Acad Sci USA 94:1338-1343
25. Flügel A, Berkowicz T, Ritter T, Labeur M, Jenne DE, Li Z, Ellwart JW, Willem M, Lassmann H, Wekerle H (2001) Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity 14:547-560
26. Merrill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE (1993) Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 151:2132-2141
27. Saoudi A, Hurez V, Kozak Y de, Kaveri SV, Kazatchkine MD, Druet P, Bellon B (1993) Human immunoglobulin preparations for intravenous use prevent experimental autoimmune uveoretinitis. Int Immunol 5:1559-1567
28. Pashov A, Dubey C, Kaveri SV, Lectard B, Huang YM, Kazatchkine MD, Bellon B (1998) Normal immunoglobulin G protects against experimental allergic encephalomyelitis by inducing transferable T cell unresponsiveness to myelin basic protein. Eur J Immunol 28:1823-1831
29. Miyagi F, Horiuchi H, Nagata I, Kitahara S, Kiyoki M, Komoriya K, Yuki N (1997) Fc portion of intravenous immunoglobulin suppresses the induction of experimental allergic neuritis. J Neuroimmunol 78:127-131