Increased proliferation within T lymphocyte subsets of HIV-infected adolescents

AIDS Research and Human Retroviruses

Volumn 18, Issue 17, 2002, Pages 1301-1310

  Starr, Stuart E ^a   Sarr, Moussa ^b   Campbell, Donald E ^a   Wilson, Craig M ^c   Douglas, Steven D ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WESTAT   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; KI 67 ANTIGEN;

ADOLESCENCE; ADOLESCENT; ADULT; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL REGENERATION; CELL SIZE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADP-RIBOSYL CYCLASE; ADULT; ANTIGENS, CD; ANTIGENS, CD38; CD4 LYMPHOCYTE COUNT; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOLOGIC MEMORY; KI-67 ANTIGEN; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; T-LYMPHOCYTE SUBSETS; VIRAL LOAD;

EID: 0036941596     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922202320886343     Document Type: Article

References (30)

1. Ibegbu C, Spira TJ, Nesheim S, et al.: Subpopulations of T and B cells in perinatally HIV-infected and noninfected age-matched children compared with those in adults. Clin Immunol Immunopathol 1994;71:27-32.
2. Rabin RL, Roederer M, Maldonado Y, et al.: Altered representation of naive and memory CD8 subsets in HIV-infected children. J Clin Invest 1995;95:2054-2060.
3. Autran B, Carcelain G, Li TS, et al.: Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997;227:112-116.
4. Cohen Stuart JWT, Slieker WAT, Rijkers GT, et al.: Early recovery of CD4+ T lymphocytes in children on highly active antiretroviral therapy. AIDS 1998; 12:2155-2159.
5. Sleasman JW, Nelson RP, Goodenow MM, et al.: Immunoreconstitution after ritonavir therapy in children with human immunodeficiency virus infection involves multiple lymphocyte lineages. J Pediatr 1999;134:597-606.
6. Vigano A, Vella S, Saresella M, et al.: Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume. AIDS 2000;14:251-261.
7. Ho DD, Neumann AU, Perelson AS, et al.: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-126.
8. Bucy RP, Hocker RD, Derdeyn CA, et al.: Initial increase in blood CD4+ lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest 1999;103: 1391-1398.
9. Wolthers KC, Wisman GBA, Otto SA, et al.: T cell telomere length in HIV-1 infection: No evidence for increased CD4+ T cell turnover. Science 1996;274:1543-1547.
10. Lempicki RA, Kovacs JA, Baseler MW, et al.: Impact of HIV-infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients. Proc Natl Acad Sci USA 2000;97:13778-13783.
11. Sachsenberg N, Perelson AS, Yerly S, et al.: Turnover of CD4+ and CD8+ T lymphocytes in HIV-1 infection as measured by Ki67 antigen. J Exp Med 1998;187:1295-1303.
12. Fleury S, De Boer RJ, and Rizzardi GP: Limited CD4+ T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy. Nature Med 1998;4:794-801.
13. Hazenberg MD, Cohen Stuart JWT, Otto SA, et al.: T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000;95:249-255.
14. Rogers AS, Futterman DK, Moscicki B, Wilson CM, Ellenberg J, and Vermund SH: The REACH Project of the Adolescent Medicine HIV/AIDS Research Network; design, methods and selected characteristics of the participants. J Adolesc Health 1998;22: 300-311.
15. Wilson CM, Houser J, Partlow C, Rudy B J, Futterman DC, Friedman LB: Adolescent Medicine HIV/AIDS Research Network. The REACH (Reaching for Excellence in Adolescent Care and Health) project: Study design, methods, and population profile. J Adolesc Health 2001;29(3 Suppl.):8-18.
16. Douglas SD, Rudy B, Muenz L, et al.: Peripheral blood mononuclear cell markers in antiretroviral therapy-naive HIV infected and high risk seronegative adolescents. AIDS 1999;13:1629-1635.
17. Ho HN, Hultin LE, Mitsuyasu RT, et al.: Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993;150:3070-3079.
18. Hultin LE, Matud JL, and Giorgi JV: Quantitation of CD38 activation antigen expression on CD8+ T cells in HIV-1 infection using CD4 expression on CD4+ T lymphocytes as a biological calibrator. Cytometry 1998;33:123-132.
19. SAS Institute: Statistical Analysis System, Release 8.1. Release TS1MO. SAS Institute, Inc., Cary, NC, 1999-2000.
20. SAS Institute: SAS/STAT User's Guide, Version 6, 4th Ed. SAS Institute, Inc., Cary, NC, 1989.
21. Douglas SD, Rudy B, Muenz L, et al.: T-lymphocyte subsets in HIV-infected and high-risk HIV-uninfected adolescents: Retention of naive T lymphocytes in HIV-infected adolescents. Arch Pediatr Adolesc Med 2000;154:375-380.
22. Mofenson LM, Korelitz J, Meyer WA, et al.: The relationship between serum human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 lymphocyte percent, and long-term mortality in HIV1-infected children. J Infect Dis 1997;175:1029-1038.
23. Jennings C, Rich K, Siegel JN, and Landay A: A phenotypic study of CD8+ lymphocyte subsets in infants using three-color flow cytometry. Clin Immunol Immunopathol 1994;71:8-13.
24. Plaeger-Marshall S, Isacescu V, O'Rourke S, et al.: T cell activation in pediatric AIDS pathogenesis: Three-color immunophenotyping. Clin Immunol Immunopathol 1994;71:19-26.
25. Giorgi JV, Hultin LE, McKeating JA, et al.: Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999;179:859-870.
26. Orendi JM, Bloem AC, Borleffs JCC, et al.: Activation and cell cycle antigens in CD4+ and CD8+ T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV-1 infection. J Infect Dis 1998;178:1279-1287.
27. Flynn P, Douglas S, Rudy B, Lathey J, Lindsey J, and Wang Y for the PACTG 381 Protocol Team: Establishment and maintenance of long-term undetectable plasma HIV-1 RNA: Correlation with immunologic reconstitution and viral dynamics. Program and Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections, Chicago, IL, 2001, p. 122 (abstract 692).
28. Hellerstein M, Hanley MB, Cesar D, et al.: Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nature Med 1999;5:83-89.
29. Mohri H, Perelson A, Tung K, et al.: Reduction of T lymphocyte turnover in HIV-1 infection by HAART: A longitudinal study using deuterated glucose labeling in vivo. Program and Abstracts of the 8th Conference on Retroviruses and Opportunistic Infections, Chicago, IL, 2001, p. 122 (abstract 269).
30. Douek DC, Koup RA, McFarland RD, Sullivan JL, and Luzuriaga K: Effect of HIV on thymic function before and after antiretroviral therapy in children. J Infect Dis 2000;181:1479-1482.