Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus

Gene Therapy

Volumn 7, Issue 3, 2000, Pages 263-270

  Kluth, D C ^a   Erwig, L P ^a   Pearce, W P ^a   Rees, A J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Glomerulonephritis; Interleukin 4; Macrophages; Nitric oxide; Recombinant adenovirus

Indexed keywords

BETA GALACTOSIDASE; CYTOKINE; GROWTH FACTOR; INTERLEUKIN 4; NITRIC OXIDE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; GLOMERULONEPHRITIS; KIDNEY ARTERY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOVIRIDAE; ALBUMINURIA; ANIMALS; CELL LINE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GLOMERULONEPHRITIS; KIDNEY GLOMERULUS; MACROPHAGE ACTIVATION; MACROPHAGES; RATS; TRANSFECTION;

EID: 0034004373     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301060     Document Type: Article

References (51)

1. Savill J, Rees AJ. Mechanisms of glomerular injury. In: Davison AM et al (eds). Oxford Textbook of Clinical Nephrology, 2nd edn. Oxford University Press: Oxford, 1997, pp 403-439.
2. Green SJ, Nacy CA, Meltzer MS. Cytokine induced synthesis of nitric oxide in macrophages: a protective host response to leishmania and other intracellular pathogens. J Leuk Biol 1991; 50: 93-103.
3. Imhof BA, Dunon D. Leukocyte migration and adhesion. Adv Immunol 1995; 58: 345-416.
4. DiPietro LA et al. MIP-1alpha as a critical macrophage chemoattractant in murine wound repair. J Clin Invest 1998; 101: 1693-1698.
5. Subramaniam M et al. Role of endothelial selectins in wound repair. Am J Pathol 1997; 150: 1701-1709.
6. Meszaros AJ, Reichner JS, Albina JE. Macrophage phagocytosis of wound neutrophils. J Leuk Biol 1999; 65: 35-42.
7. Tsuyuki S et al. Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways. J Clin Invest 1995; 96: 2924-2931.
8. Cox G, Crossley J, Xing Z. Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am J Resp Cell Mol Biol 1995; 12: 232-237.
9. Savill J. Apoptosis in resolution of inflammation. J Leuk Biol 1997; 61: 375-380.
10. Grigg JM et al. Neutrophil apoptosis and clearance from neonatal lungs. Lancet 1991; 338: 720-722.
11. Ajuebor MN et al. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. J Immunol 1999; 162: 1685-1691.
12. Akbar AN et al. The specific recognition by macrophages of CD8+, CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections. J Exp Med 1994; 180: 1943-1947.
13. Ferkol T, Perales JC, Mularo F, Hanson RW. Receptor-mediated gene transfer into macrophages. Proc Natl Acad Sci USA 1996; 93: 101-105.
14. Naldini L et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267.
15. Huang S, Endo RI, Nemerow GR. Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J Virol 1995; 69: 2257-2263.
16. Haddada H et al. Efficient adenovirus-mediated gene transfer into human blood monocyte-derived macrophages. Biochem Biophys Res Commun 1993; 195: 1174-1183.
17. Wan Y et al. Dendritic cells transduced with an adenoviral vector encoding a model tumor-associated antigen for tumor vaccination. Hum Gene Ther 1997; 8: 1355-1363.
18. Bondeson J et al. Selective regulation of cytokine induction by adenoviral gene transfer of IkBa into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor kB independent. J Immunol 1999; 162: 2939-2945.
19. Zhong L, Granelli-Piperno A, Choi Y, Steinman RM. Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells. Eur J Immunol 1999; 29: 964-972.
20. Unanue ER, Dixon FJ. Experimental glomerulonephritis: immunological events and pathogenetic mechanisms. Adv Immunol 1967; 6: 1-90.
21. Jones N, Shenk T. Isolation of adenovirus tvpe 5 host range deletion mutants defective for transformation of rat embryo cells. Cell 1979; 16: 683-689.
22. Erwig LP, Kluth DC, Walsh GM, Rees AJ. Initial cytokine exposure determines macrophage function and renders them unresponsive to other cytokines. J Immunol 1998; 161: 1983-1988.
23. Tam FW et al. Interleukin-4 ameliorates experimental glomerulonephritis and up-regulates glomerular gene expression of IL-1 decoy receptor. Kidney Int 1997; 52: 1224-1231.
24. Karkar AM et al. Abrogation of glomerular injury in nephrotoxic nephritis by continuous infusion of interleukin-6. Kidney Int 1997; 52: 1313-1320.
25. Nathan CF, Murray HW, Cohn ZA. The macrophage as an effector cell. New Engl Med 1980; 303: 622-626.
26. Seljilid R, Busund L-TR. The biology of macrophages: II inflammation and tumours. Eur J Haematol 1994; 52: 1-12.
27. Karupiah G et al. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 1993; 261: 1445-1448.
28. Smith PD et al. Cytomegalvirus induction of tumour necrosis factor-a by human monocytes and mucosal macrophages. J Clin Invest 1992; 90: 1642-1648.
29. Henke A et al. Coxsackie B3-induced production of tumour necrosis factor-a, IL-1b and IL-6 in human monocytes. J Immunol 1992; 148: 2270-2277.
30. Yang Y et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
31. Guerette B et al. Inflammatory damage following first generation replication-defective adenovirus controlled by anti-LFA-1. J Leuk Biol 1997; 61: 533-538.
32. Morral N et al. Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors. Hum Gene Ther 1997; 8: 1275-1286.
33. Zhang H et al. Inhibition of tumour necrosis factor a decreases inflammation and prolongs adenovirus gene expression in lung and liver. Hum Gene Ther 1998; 9: 1875-1884.
34. Worgall S et al. Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract. Hum Gene Ther 1997; 8: 1675-1684.
35. Wolff G et al. Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. J Virol 1997; 71: 624-629.
36. Tomita N et al. Direct in vivo gene introduction into rat kidney. Biochem Biophys Res Commun 1992; 186: 129-134.
37. Isaka Y et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney. J Clin Invest 1993; 92: 2597-2601.
38. Heikkila P et al. Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome. Gene Therapy 1996; 3: 21-27.
39. Moullier P et al. Adenoviral-mediated gene transfer to renal tubular cells in vivo. Kidney Int 1994; 45: 1220-1225.
40. Sukhatme VP, Cowley BD, Zhu G. Gene transfer into kidney tubules and vasculature by adenoviral vectors. Exp Nephrol 1997; 5: 137-143.
41. Zeigler ST et al. Molecular conjugate-mediated gene transfer into isolated human kidneys. Transplantation 1996; 61: 812-817.
42. McDonald GA et al. Enhanced adenoviral gene transfer to kidney vasculature utilizing a fiber modified vector. J Am Soc Nephrol 1997; 8: 502A (Abstr.).
43. Kitamura M. Gene delivery into the glomerulus via mesangial cell vectors. Exp Nephrol 1997; 5: 118-125.
44. Kitamura M, Suto TS. Transfer of genetically engineered macrophages into the glomerulus. Kidney Int 1997; 51: 1274-1279.
45. Yokoo T et al. Inflamed site specific gene delivery using bone marrow derived CD11b+ CD18+ vehicle cells in mice. Hum Gene Ther 1998; 9: 1731-1738.
46. Kolb H, Kolb-Bachofen V. Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator? Immunol Today 1998; 19: 556-561.
47. Ghivizzani SC et al. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal antiarthritic effects. Proc Natl Acad Sci USA 1998; 95: 4613-4618.
48. Bellingan GJ et al. In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes. J Immunol 1996; 157, 2577-2585.
49. Tomosugi NI et al. Modulation of antibody-mediated glomerular injury in vivo by bacterial lipopolysaccharide, tumor necrosis factor, and IL-1. J Immunol 1989; 142, 3083-3090.
50. Graham F, Prevec L. Murray EJ (eds). Manipulation of adenovirus vectors. Methods in Molecular Biology: Gene transfer and expression protocols. The Humuna Press: Clifton NJ, 1991, pp 109-128.
51. Bondi A et al. The use of β-galactosidase as a tracer in immunohistochemistry. Histochem 1982; 76: 153-158.