IRE_FINDER - Computational search of iron response element in human and mouse UTRs

Acta Biochimica et Biophysica Sinica

Volumn 34, Issue 6, 2002, Pages 743-747

  Chen, Xin ^a   Wang, Lu Quan ^b   Huang, Yi ^a   Qiu, Ping ^b   Murgolo, Nicholas J ^b   Greene, Jonathan R ^b   Wu, Cai Hong ^a   Jiang, Ying ^a  

^a PEKING UNIVERSITY   (China)

^b NONE

Author keywords

Iron regulatory protein; Iron responsive element (IRE); Stem loop structures; Untranslated region (UTR)

Indexed keywords

IRON; IRON BINDING PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; COMPUTER PROGRAM; CONFORMATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GENETICS; HUMAN; IRON RESPONSIVE ELEMENT; MATHEMATICAL ANALYSIS; METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; UNINDEXED SEQUENCE; UNTRANSLATED REGION;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BINDING SITES; GENE EXPRESSION REGULATION; HUMANS; IRON; IRON-BINDING PROTEINS; MICE; NUCLEIC ACID CONFORMATION; RESPONSE ELEMENTS; SOFTWARE;

ANIMALIA;

EID: 0036934388     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Yang R, Pan JW, Zhu MY. The mechanism of translation initiation in eukaryotes. Hereditas, 1999, 21(5): 67-70
2. Laing LG, Hall KB. A model of the iron responsive element RNA hairpin loop structure determined from NMR and thermodynamic data. Biochemistry, 1996, 35: 13586-13596
3. Samaniego F, Chin J, Iwai K, Rouault TA, Klausner RD. Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. J Biol Chem, 1994, 269: 30904-30910
4. Rouault TA, Tang CK, Kaptain S, Burgess WH, Haile DJ, Samaniego F, McBride OW et al. Cloning of the cDNA encoding an RNA regulatory protein - The human iron-responsive element-binding protein. Proc Natl Acad Sci USA, 1990, 87: 7958-7962
5. Theil EC, McKenzie RA, Sierzputowska-Gracz H. Structure and function of IREs, the noncoding mRNA sequences regulating synthesis of ferritin, transferrin receptor and (erythroid) 5-aminole-vulinate synthase. Adv Exp Med Biol, 1994, 356: 111-118
6. Theil EC. The IRE (iron regulatory element) family: Structures which regulate mRNA translation or stability. Biofactors, 1993, 4: 87-93
7. Matthias WH, Lukas CK. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci USA, 1996, 93: 8175-8182
8. Henderson BR, Menotti E, Bonnard C, Kuhn LC. Optimal sequence and structure of iron-responsive elements selection of RNA stem -loops with high affinity for iron regulatory factor. J Biol Chem, 1994, 269: 17481-17489
9. Qiu LQ, Wu ZL. Iron, oxygen free radical and renal tubule epithelial cells. Chinese J Nephrol, 1999, 15(1): 60-63
10. Pesole G, Liuni S, D'Souza M. PatSearch: A pattern matcher software that finds functional elements in nucleotide and protein sequences and assesses their statistical significance. Bioinformatics, 2000, 16(5): 439-450
11. Dandekar T, Beyer K, Bork P, Kenealy MR, Pantopoulos K, Hentze M, Sonntag-Buck V et al. Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: Combining experimental and computational approaches. Bioinformatics, 1998, 14(3): 271-278
12. Cairo G, Pietrangelo A. Iron regulatory proteins in pathobiology. Biochem J, 2000, 352: 241-250
13. Yang H, Cao XB, Huang ZX, Sun SG. Recent progress in studies on the correlation between iron and Parkinson's disease. Foreign Medical Science on Neurology & Neurosurgery, 2000, 27(4): 180-183