Pallido-nigral spheroids in nonhuman primates: Accumulation of heat shock proteins in astroglial processes

Acta Neuropathologica

Volumn 103, Issue 3, 2002, Pages 276-280

  Willwohl, Dirk ^a   Kettner, Mattias ^a   Braak, Heiko ^a   Hubbard, Gene B ^b   Dick Jr , Edward J ^c   Cox, Ann B ^c   Schultz, Christian ^a  

^a GOETHE UNIVERSITY   (Germany)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

Alpha B crystallin; Heat shock proteins; Iron; Nonhuman primates; Spheroid bodies

Indexed keywords

ALPHA CRYSTALLIN; BIOLOGICAL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 27; MICROTUBULE ASSOCIATED PROTEIN 2; UBIQUITIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BABOON; BRAIN DISEASE; BRAIN NERVE CELL; BRAIN REGION; CELL STRUCTURE; CELL SWELLING; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENDRITE; FEMALE; GLOBUS PALLIDUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MACACA; MACROGLIA; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RHESUS MONKEY; SPHEROID CELL; STRUCTURE ANALYSIS; SUBSTANTIA NIGRA;

ANIMALS; ASTROCYTES; BRAIN NEOPLASMS; CRYSTALLINS; DISEASE MODELS, ANIMAL; FEMALE; GLOBUS PALLIDUS; HEAT-SHOCK PROTEINS; MACACA MULATTA; MALE; NEOPLASM PROTEINS; PAPIO; SPHEROIDS, CELLULAR; SUBSTANTIA NIGRA; UBIQUITIN;

EID: 0036934241     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-001-0466-8     Document Type: Article

References (23)

1. Arai N (1995) Grumose or foamy spheroid bodies involving astrocytes in the human brain. Neuropathol Appl Neurobiol 21: 238-245
2. Braak H, Braak E, Ohm TG, Bohl J (1988) Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment. Stain Technol 63: 197-200
3. Bronson RT, Schoene W (1980) Spontaneous pallido-nigral accumulation of iron pigment and spheroid-like structures in macaque monkeys. J Neuropathol Exp Neurol 39: 181-196
4. Castellani RJ, Siedlak SL, Perry G, Smith MA (2000) Sequestration of iron by Levy bodies in Parkinson's disease. Acta Neuropathol 100: 111-114
5. Chai Y, Koppenhafer SL, Bonini NM, Paulson HL (1999) Analysis of the role of heat shock protein (hsp): molecular chaperones in polyglutamine disease. J Neurosci 19: 10338-10347
6. Chan HY, Warrick JM, Gray-Board GL, Paulson HL, Bonini NM (2000) Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Hum Mol Genet 9: 2811-2820
7. Chin SSN, Goldman JE (1996) Glial inclusions in CNS degenerative diseases. J Neuropathol Exp Neurol 55: 499-508
8. Gelman BB (1995) Iron in CNS disease. J Neuropathol Exp Neurol 54: 477-486
9. Head MW, Corbin E, Goldman JE (1993) Overexpression and abormal modification of the stress proteins alpha-B crystallin and hsp27 in Alexander disease. Am J Pathol 143:1743-1753
10. Head MW, Corbin E, Goldman JE (1994) Coordinate and independent regulation of alpha-B crystallin and hsp27 expression in response to physiological stress. J Cell Physiol 159: 41-50
11. Jellinger K, Jirasek A (1971) Neuroaxonal dystrophy in man: character and natural history. Acta Neuropathol (Berlin) [Suppl V]: 3-16
12. Jellinger KA, Kienzl E, Rumpelmaier G, Paulus W, Riederer P, Stachelberger H, Youdim MBH, Ben-Shachar D (1993) Iron and ferritin in substantia nigra of Parkinson's disease. Adv Neurol 60: 267-272
13. Messing A, Goldman JE, Johnson AB, Brenner M (2001) Alexander disease: new insights from genetics. J Neuropathol Exp Neurol 60: 563-573
14. Ohtsuka K, Suzuki T (2000) Roles of molecular chaperones in the nervous system. Brain Res Bull 53: 141-146
15. Olanow CW (1994) Hallervorden-Spatz syndrome: an iron storage disorder. In: Calne DB (ed) Neurodegenerative diseases. Saunders, Philadelpha, pp 807-823
16. Riederer P, Dirr A, Goetz M, Sofic E, Jellinger KA, Youdim MBH (1992) Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease. Ann Neurol 32: 101-104
17. Santoro MG (2000) Heat shock factors and the control of the stress response. Biochem Pharmacol 59: 55-63
18. Schultz C, Deghani F, Hubbard GB, Thal DR, Struckhoff G, Braak E, Braak H (2000) Filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons. J Neuropathol Exp Neurol 59: 39-52
19. Schultz C, Hubbard GB, Rüb U, Braak E, Braak H (2000) Age-related progression of tau pathology in brains of baboons. Neurobiol Aging 21: 905-911
20. Schultz C, Dick EJ, Cox AB, Hubbard GB, Braak E, Braak H (2001) Expression of stress proteins alpha-B crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys. Neurobiol Aging 22: 677-682
21. Seitelberger F (1986) Neuroaxonal dystrophy: its relation to aging and neurological diseases. Hand Clin Neurol 5: 391-415
22. Siddiqi ZA, Peters A (1999) The effect of aging on pars compacta of the substantia nigra in rhesus monkey. J Neuropathol Exp Neurol 58: 903-920
23. Youdim MBH (1994) Inorganic neurotoxins in neurodegenerative disorders without primary dementia. In: Calne DB (ed) Neuodegenerative diseases. Saunders, Philadelphia, pp 251-275