Saturation and self-inhibition of rat hippocampal GABAA receptors at high GABA concentrations

European Journal of Neuroscience

Volumn 16, Issue 12, 2002, Pages 2253-2259

  Mercik, Katarzyna ^a,b   Zarnowska, Ewa D ^a   Mandat, Maria ^a   Mozrzymas, Jerzy W ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Patch clamp; Receptor gating; Self block; Ultrafast perfusion

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CONTROLLED STUDY; DESENSITIZATION; ELECTRIC POTENTIAL; EVOKED RESPONSE; HIPPOCAMPUS; INHIBITION KINETICS; MEMBRANE CURRENT; NONHUMAN; PRIORITY JOURNAL; RAT; REBOUND; RECEPTOR INTRINSIC ACTIVITY; RECORDING; STEADY STATE;

ANIMALS; ANIMALS, NEWBORN; BINDING, COMPETITIVE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; NEURAL INHIBITION; NEURONS; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 0036924875     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02307.x     Document Type: Article

References (24)

1. Andjus, P.R., Stevic-Markovic, Z. & Cherubini, E. (1997) Immunoglobulins from motoneurone disease patients enhance glutamate release from rat hippocampal neurones in culture. J. Physiol. (Lond.), 504, 103-112.
2. A receptor gating. J. Neurosci., 20, 8618-8627.
3. Colquhoun, D. & Ogden, D.C. (1988) Activation of ion channels in the frog end-plate by high concentrations of acetylcholine. J. Physiol. (Lond.), 395, 131-159.
4. Colquhoun, D., Ogden, D.C. & Mathie, A. (1987) Nicotinic acetylcholine receptors of nerve and muscle: Functional aspects. Trends Pharmacol. Sci., 8, 465-472.
5. Curmi, J.P., Premkumar, L.S., Birnir, B. & Gage, P.W. (1993) The influence of the membrane potential on chloride channels activated by GABA in rat cultured hippocampal neurons. J. Membrane Biol., 136, 273-280.
6. Franke, Ch & Dudel, J. (1987) Liquid filament switch for ultra-fast exchanges of solutions at excised patches at synaptic membranes of crayfish muscle. Neurosci. Lett., 77, 199-204.
7. Franke, Ch, Parnas, H., Hovav, G. & Dudel, J. (1993) A molecular scheme for the reaction between acetylcholine and nicotinic channels. Biophys. J., 64, 339-356.
8. A-receptor desensitization in cultured chick cerebral neurons. Synapse, 12, 169-171.
9. Jonas, P. (1995) Fast application of agonist to isolated membrane patches. In Sakmann, B. & Neher, E. (eds), Single-Channel Recording. Plenum Press, New York, pp. 231-243.
10. A receptor kinetics. Soc. Neurosci. Abstr., 25, 1246.
11. A receptor. J. Neurosci., 18, 8590-8604.
12. A channel responses to brief agonist pulses. Neuron, 15, 181-191.
13. Lester, R.A.J. & Jahr, C.E. (1992) NMDA channel behaviour depends on agonist affinity. J. Neurosci., 12, 635-643.
14. Liu, Y. & Dilger, J.P. (1991) Opening rate of acetylcholine receptor channels. Biophys. J., 60, 424-432.
15. Maconochie, D.J. & Steinbach, J.H. (1995) Block by acetylcholine of mouse muscle nicotinic receptors, stably expressed in fibroblasts. J. Gen. Physiol., 106, 113-147.
16. Maconochie, D.J. & Steinbach, J.H. (1998) The channel opening rate of adult-and fetal-type mouse muscle nicotinic receptors activated by acetylcholine. J. Physiol. (Lond.), 506, 53-72.
17. A receptor open? Neuron, 12, 61-71.
18. Magleby, K.L. & Stevens, C.F. (1972) A quantitative description of the end-plate currents. J. Physiol. (Lond.), 223, 173-197.
19. A receptors. J. Physiol. (Lond.), 515, 711-727.
20. A receptors. J. Neurosci., 19, 2474-2488.
21. Ogden, D.C. & Colquhoun, D. (1985) Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction. Proc. R. Soc. Lond. B Biol. Sci., 225, 329-355.
22. Oh, D.J. & Dichter, M.A. (1992) Desensitization of GABA-induced currents in cultured rat hippocampal neurons. Neuroscience, 49, 571-576.
23. Weiss, D.S. (1988) Membrane potential modulates the activation of GABA-gated channels. J. Neurophysiol., 59, 514-527.
24. Yoon, K.W. (1994) Voltage-dependent modulation of GABAA receptor channel desensitization in rat hippocampal neurons. J. Neurophysiol., 71, 2151-2160.