Association studies of QTL for multi-allele markers by mixed models

Human Heredity

Volumn 54, Issue 3, 2002, Pages 132-150

  Fan, Ruzong ^a,b   Jung, Jeesun ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Association study; Linkage analysis; Mixed models; Quantitative trait locus

Indexed keywords

ALLELE; ANALYSIS OF VARIANCE; ARTICLE; CHROMOSOME 16; CHROMOSOME 4; CHROMOSOME ANALYSIS; FAMILY; GENE LINKAGE GROUP; GENE LOCUS; GENETIC ALGORITHM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC DATABASE; GENETIC LINKAGE; GENETIC MODEL; GENETIC TRAIT; HETEROZYGOTE; HUMAN; MARKER GENE; PROGENY; QUANTITATIVE TRAIT LOCUS;

ASTHMA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 4; DATA INTERPRETATION, STATISTICAL; FEMALE; GENETIC MARKERS; HETEROZYGOTE; HUMANS; MALE; MODELS, GENETIC; PEDIGREE; QUANTITATIVE TRAIT LOCI; RESEARCH DESIGN;

EID: 0036920265     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068839     Document Type: Article

References (26)

1. Abecasis GR, Cardon LR, Cookson WOC (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292.
2. Allison DB (1997) Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet 60:676-690.
3. Cardon LR (2000) A sib-pair regression model of linkage disequilibrium for quantitative traits. Hum Hered 50:350-358.
4. Cookson W, Abecasis G (2001) Oxford genome screen for asthma-associated traits. Genet Epidemiol 21 (Suppl 1):S1-S3.
5. Daniel SE, Bhattacharrya S, James A, et al (1996) A genome-wide search for quantitative trait loci underlying asthma. Nature 383:247-250.
6. Falconer DS, Mackay TFC (1996) Introduction to quantitative genetics, ed 4, pp 15-19. London and New York: Longman.
7. Fan R, Floros J, Xiong M (2002) Models and tests of linkage and association studies of QTL for multi-allele marker loci. Hum Hered 53:130-145.
8. Fan RZ, Xiong MM (2003) Linkage and association studies of QTL for nuclear families by mixed models. Biostatistics (in press). http://stat.tamu.edu/~rfan/paper.html/nuclear_family.pdf.
9. Fulker DW, Cherny SS, Sham PC, Hewitt JK (1999) Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 64:259-267.
10. George V, Tiwari HK, Zhu XF, Elston RC (1999) A test of transmission/disequilibrium for quantitative traits in pedigree data, by multiple regression. Am J Hum Genet 65:236-245.
11. Graybill FA (1976) Theory and Application of the Linear Model. Pacific Grove, California.
12. Haseman JK, Elston RC (1972) The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19.
13. Miller JJ (1977) Asymptotic properties of maximum likelihood estimates in the mixed model of the analysis of variance. Ann Statistics 5: 746-762.
14. Pinheiro JC (1994) Topics in Mixed-effects models. Ph.D thesis, University of Wisconsin-Madison.
15. Pinheiro JC, Bates DM (2000) Mixed-effects models in S and S-plus. Spinger, New York.
16. Rabinowitz D (1997) A transmission disequilibrium test for quantitative trait loci. Hum Hered 47:342-350.
17. Sham PC, Cherny SS, Purcell S, Hewitt JK (2000) Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am J Hum Genet 66:1616-1630.
18. Sham PC, Curtis D (1995) An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 59:323-336.
19. Spielman RS, Ewens WJ (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
20. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
21. Van den Oord EJCG, Sneider H (2002) Including measured genotypes in statistical models to study the interplay of multiple factors affecting complex traits. Behavior Genetics 32:1-22.
22. Weiss L (1971) Asymptotic properties of maximum likelihood estimators in some nonstandard cases I. J Am Stat Ass 66:345-350.
23. Weiss L (1973) Asymptotic properties of maximum likelihood estimators in some nonstandard cases II. J Am Stat Ass 68:428-430.
24. Xiong MM, Krushkal J, Boerwinkle E (1998) TDT statistics for mapping quantitative loci. Ann Hum Genet 62:431-452.
25. Zhu XF, Elston RC (2000) Power comparison of regression methods to test quantitative traits for association and linkage. Genet Epidemiol 18:322-330.
26. Zhu XF, Elston RC (2001) Transmission/disequilibrium tests for quantitative traits. Genet Epidemiol 20:57-74.