The Yin and Yang of cholesteryl ester transfer protein and atherosclerosis

Clinical Science

Volumn 103, Issue 6, 2002, Pages 595-597

  Watts, Gerald F ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLPROPANETHIOIC ACID S [2 [1 (2 ETHYLBUTYL)CYCLOHEXYLCARBOXAMIDO]PHENYL] ESTER; APOLIPOPROTEIN B; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN INHIBITOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

AORTA ATHEROSCLEROSIS; ATHEROGENESIS; CHOLESTEROL TRANSPORT; CORONARY ARTERY DISEASE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; NONHUMAN; NOTE; PRIORITY JOURNAL; RABBIT;

EID: 0036911578     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs1030595     Document Type: Note

References (20)

1. Gotto, A. M. (2001) Low high-density lipoprotein cholesterol as a risk factor in coronary heart disease. Circulation 103, 2213-2218
2. Sacks, F. M., for the Expert Group on HDL Cholesterol (2002) The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart disease: Expert Group recommendations. Am. J. Cardiol. 90, 139-143
3. Von Eckardstein, A., Nofer, J.-R. and Assmann, G. (2001) High density lipoproteins and arteriosclerosis: Role of cholesterol efflux and reverse cholesterol transport. Arterioscler. Thromb. Vasc. Biol. 21, 13-27
4. Nofer, J.-R., Kehrel, B., Fobker, M., Levkau, B., Assmann, G. and von Eckardstein, A. (2002) HDL and arteriosclerosis: Beyond reverse cholesterol transport. Atherosclerosis (Shannon, Irel.) 161, 1-16
5. Barter, P. J. and Rye, K.-A. (2001) Cholesteryl ester transfer protein, high density lipoprotein and arterial disease. Curr. Opin. Lipidol. 12, 377-382
6. Tall, A. R., Jiang, X.-C., Luo, Y. and Silver, D. (2002) Lipid transfer proteins, HDL metabolism, and atherogenesis. Arterioscler. Thromb. Vasc. Biol. 20, 1185-1191
7. Zhong, S., Sharp, D. S., Grove, J. S. et al. (1997) Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. J. Clin. Invest. 97, 2917-2923
8. Hirano, K., Yamashita, S., Kuga, Y. et al. (1959) Atherosclerotic disease in marked hyperalpha-lipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. Arterioscler. Thromb. Vasc. Biol. 15, 1849-1856
9. Agerholm-Larsen, B., Nordestgaard, B. G., Steffensen, R. et al. (2000) Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene. Circulation 101, 1907-1912
10. Agerholm-Larsen, B., Tybjaerg-Hansen, A., Schnohr, P. et al. (2000) Common cholesteryl ester transfer protein mutations, decreased HDL cholesterol, and possible decreased risk of ischemic heart disease. The Copenhagen City Heart Study. Circulation 102, 2197-2203
11. Marotti, K. R., Castle, C. K., Boyle, T. P. et al. (1993) Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein. Nature (London) 364, 73-75
12. Plump, A. S., Masucci-Magoulas, L., Bruce, T. P. et al. (1999) Increased atherosclerosis in apoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler. Thromb. Vasc. Biol. 19, 1105-1110
13. Hayek, T., Masucci-Magoulas, L., Jiang, X. et al. (1995) Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene. J. Clin. Invest. 96, 2071-2074
14. Sugano, M., Makino, N., Sawada, S. et al. (1998) Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits. J. Biol. Chem. 273, 5033-5036
15. Rittershaus, C. W., Miller, D. P., Thomas, L. J. et al. (2000) Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20, 2106-2112
16. Okamoto, H., Yonemori, F., Wakitani, K. et al. (2000) A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature (London) 406, 203-207
17. Inazu, A., Huang, Z., Nohara, A., Higashikata, T. and Mabuchi, H. (2002) Cholesterol ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia. Clin. Sci. 103, 587-594
18. Haraki, T., Inazu, A., Yagi, K., Kajinami, K., Koizumi, J. and Mabuchi, H. (1997) Clinical characteristics of double heterozygotes with familial hypercholesterolaemia and cholesteryl ester transfer protein deficiency. Atherosclerosis (Shannon, Irel.) 132, 229-236
19. de Grooth, G. J., Kuivenhoven, J. A., Stalenhoef, A. F. H. et al. (2002) Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: A randomised phase II dose-response study. Circulation 105, 2159-2165
20. Attie, A. D., Kastelein, J. P. and Hayden, M. R. (2001) Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42, 1717-1726