Mood-stabilizing properties of lamotrigine: A review of data from controlled clinical trials

Psychiatric Annals

Volumn 32, Issue 12, 2002, Pages 766-772

  Leadbetter, Robert ^a   Messenheimer, John ^a   Bentley, Beth ^a   Greene, Paul ^a   Huffman, Russell ^a   Spaulding, Theodore ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMOTRIGINE; PLACEBO;

ATYPICAL DEPRESSION; BIPOLAR DISORDER; CLINICAL TRIAL; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; HAMILTON SCALE; HEADACHE; HUMAN; INFECTION; INJURY; MAINTENANCE DRUG DOSE; MANIC PSYCHOSIS; MEDICAL ASSESSMENT; MONOTHERAPY; NAUSEA; PAIN; RATING SCALE; REVIEW; SOMNOLENCE; STEVENS JOHNSON SYNDROME; VERTIGO;

EID: 0036909068     PISSN: 00485713     EISSN: None     Source Type: Journal    
DOI: 10.3928/0048-5713-20021201-12     Document Type: Review

References (32)

1. Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd G. A double-blind, placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. J Clin Psychiatry. 1999;60:79-88.
2. Fatemi SH, Rapport DJ, Calabrese JR, Thuras P. Lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry. 1997;58:522-527.
3. Fogelson DL, Sternbach H. Lamotrigine treatment of refractory bipolar disorder. J Clin Psychiatry. 1997;58:271-273.
4. Kusumakar V, Yatham LN. Lamotrigine treatment of rapid cycling bipolar disorder. Am J Psychiatry. 1997;154:1171-1172.
5. Sporn J, Sachs GS. The anticonvulsant lamotrigine in treatment-resistant manic-depressive illness. J Clin Psychopharmacol. 1997;17:185-189.
6. Walden J, Hesslinger B, van Calker D, Berger M. Addition of lamotrigine to valproate may enhance efficacy in the treatment of bipolar affective disorder. Pharmacopsychiatry. 1996;29:193-195.
7. Calabrese JR, Suppes T, Bowden CL, et al. A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry. 2000;61:841-850.
8. Frye MA, Ketter TA, Kimbrell TA, et al. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharm. 2000;20:607-614.
9. Bowden CL, Calabrese JR, McElroy SL, et al. The efficacy of lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder. Biol Psychiatry. 1999;45:953-958.
10. Calabrese JR, Bowden CL, McElroy SL, et al. Spectrum of activity of lamotrigine in treatment-refractory bipolar disorder. Am J Psychiatry. 1999;156:1019-1023.
11. Berk M. Lamotrigine and the treatment of mania in bipolar disorder. Eur Neuropsychopharmacol. 1999;9(Suppl 4):S119-S123.
12. Ichim L, Berk M, Brook S. Lamotrigine compared with lithium in mania: A double-blind randomized controlled trial. Ann Clin Psychiatry. 2000;12:5-10.
13. Post RM, Denicoff KD, Frye MA, et al. A history of the use of anticonvulsants as mood stabilizers in the last two decades of the 20th century. Neuropsychobiology. 1998;38:152-166.
14. Ketter TA, Calabrese JR. Stabilization of mood from below versus above baseline in bipolar disorder: A new nomenclature. J Clin Psychiatry. 2002;63:146-151.
15. American Psychiatric Association. Practice guidelines for the treatment of patients with bipolar disorder. Am J Psychiatry. 2002;159:1-50.
16. Yatham LN, Kusumakar V, Calabrese JR, Rao R, Scarrow G, Kroeker G. Third-generation anti-convulsants in bipolar disorder: A review of efficacy and summary of clinical recommendations. J Clin Psychiatry. 2002;63:275-283.
17. Bowden CL, Ghaemi N, Gyulai L, et al. Lamotrigine delays mood episodes in recently depressed bipolar I patients. In: New Research Abstracts of the 155th Annual Meeting of the American Psychiatric Association; May 18-23, 2002; Philadelphia, PA, p 81.
18. Bowden CL, Calabrese JR, Sachs G, et al. A randomized, placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. In: Scientific Abstracts of the 40th Annual Meeting of the American College of Neuropsychopharmacology; December 9-13, 2001; Waikoloa, HI. p. 238.
19. Messenheimer JA. Rash in adult and pediatric patients treated with lamotrigine. Can J Neurol Sci. 1998;25:S14-S18.
20. Lamictal® (lamotrigine) product information. Research Triangle Park, NC: Glaxo Wellcome Inc., 2001.
21. Montgomery SA, Schatzberg AF, Guelfi JD, et al. Pharmacotherapy of depression and mixed states in bipolar disorder. J Affect Disord. 2000;59(Suppl 1):S39-S56.
22. Calabrese JR, Rapport DJ, Kimmel SE, Shelton MD. Controlled trials in bipolar I depression: Focus on switch rates and efficacy. Eur Neuropsychopharm. 1999;9(Suppl 4):S109-S112.
23. Howland RH. Induction of mania with serotonin reuptake inhibitors. J Clin Psychopharmacol. 1996;16:425-427.
24. Compton MT, Nemeroff CB. The treatment of bipolar depression. J Clin Psychiatry. 2000;61(Suppl 9):57-67.
25. Peet M. Induction of mania with selective serotonin reuptake inhibitors and tricyclic antidepressants. Br J Psychiatry. 1994;164:549-550.
26. Sachs GS. Bipolar mood disorder: Practical strategies for acute and maintenance phase treatment. J Clin Psychopharmacol. 1996;16(Suppl 1):32S-47S.
27. Bowden CL. New concepts in mood stabilization: Evidence for the effectiveness of valproate and lamotrigine. Neuropsychopharmacol. 1998;19:194-199.
28. Calabrese JR, Rapport DJ. Mood stabilizers and the evolution of maintenance study designs in bipolar I disorder. J Clin Psychiatry. 1999;60(Suppl 5):5-15.
29. Ghaemi SN. On defining 'mood stabilizer.' Bipolar Disord. 2001;3:154-158.
30. Keck PE Jr, McElroy SL, Richtand N, et al. What makes a drug a primary mood stabilizer? Mol Psychiatry. 2002;7:S8-S14.
31. Nemeroff CG. An ever-increasing pharmacopoeia for the management of patients with bipolar disorder. J Clin Psychiatry. 2000;61(Suppl 13):19-25.
32. Calabrese JR, Shelton MD, Bowden CL, et al. Bipolar rapid cycling: Focus on depression as its hallmark. J Clin Psychiatry. 2001;62(Suppl 14):34-41.