Hypothalamic and hippocampal release of serotonin in rats bred for hyper- or hypo-anxiety

Stress

Volumn 5, Issue 4, 2002, Pages 299-305

  Umriukhin, A E ^a   Wigger, A ^b   Singewald, N ^c   Landgraf, R ^b  

^a P K ANOKHIN INSTITUTE OF NORMAL PHYSIOLOGY   (Russian Federation)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Emotionality; High anxiety related behavior (HAB); Microdialysis; Paraventricular nucleus; Stress

Indexed keywords

SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ANXIETY; ARTICLE; BEHAVIOR; BRAIN; CONTROLLED STUDY; EMOTIONAL STRESS; FEMALE; HIPPOCAMPUS; HORMONE RELEASE; MALE; MICRODIALYSIS; NEUROENDOCRINOLOGY; NONHUMAN; PHYSICAL STRESS; PRIORITY JOURNAL; RAT; SWIMMING;

ANIMALS; ANXIETY; BREEDING; FEMALE; HIPPOCAMPUS; HYPOTHALAMUS; MALE; MICRODIALYSIS; OSMOLAR CONCENTRATION; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, WISTAR; SEROTONIN; SPACE PERCEPTION; SWIMMING;

EID: 0036908778     PISSN: 10253890     EISSN: None     Source Type: Journal    
DOI: 10.1080/1025389021000061200     Document Type: Article

References (33)

1. Calogero A.E., Bernardini, R., Margioris, A.N., Bagdy, G., Gallucci, W.T., Munson, P.J., Tamarkin, L., Tomai, T.P., Brady, L., Gold, P.W. and Chrousos, G.P. (1989) "Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami", Peptides 10, 189-200.
2. De Bellis, M.D., Gold, P.W., Geracioti, T.D., Listwak, S.J. and Kling, M.A. (1993) "Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression", Am. J. Psychiatry 150, 656-657.
3. File, S.E., Kenny, P.J. and Cheeta, S. (2000) "The role of the dorsal hippocampal serotonergic and cholinergic systems in the modulation of anxiety", Pharmacol. Biochem. Behav. 66, 65-72.
4. Frazer, A., Hensler, J.G., et al. (1999) In: Siegel, G.J., eds, Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th Ed. (Lippincott-Raven, Philadelphia), pp 263-292.
5. Gould, E. (1999) "Serotonin and hippocampal neurogenesis", Neuropsychopharmacology 21, 46S-51S.
6. Handley, S.L. and McBlane, J.W. (1993) "5HT drugs in animal models of anxiety", Psychopharmacology 112, 13-20.
7. Henniger, M.S.H., Ohl, F., Hoelter, S.M., Weissenbacher, P., Toschi, N., Loerscher, P., Wigger, A., Spanagel, R. and Landgraf, R. (2000) "Unconditioned anxiety and social behavior in two rat lines selectively bred for high and low anxiety-related behavior", Behav. Brain Res. 111, 153-163.
8. Jorgensen, H., Knigge, U., Kjaer, A., Vadsholt, T. and Warberg, J. (1998) "Serotonergic involvement in stress-induced ACTH release", Brain Res. 811, 10-20.
9. Kaehler, S.T., Singewald, N., Sinner, C., Thurnher, C. and Philippu, A. (2000) "Conditioned fear and inescapable shock modify the release of serotonin in the locus coeruleus", Brain Res. 859, 249-254.
10. Karten, Y.J.G., Nair, S.M., van Essen, L., Sibug, R. and Joels, M. (1999) "Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons", PNAS 96, 13456-13461.
11. Keck, M.E., Wigger, A., Welt, T., Mueller, M.B., Gesing, A., Reul, J.M.H.M., Holsboer, F., Landgraf, R. and Neumann, I.D. (2001) "Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: Implications for pathogenesis of affective disorders", Neuropsychopharmacology 26, 94-105.
12. Keck, M.E., Welt, T., Mueller, M.B., Uhr, M., Ohl, F., Wigger, A., Toschi, N., Holsboer, F. and Landgraf, R. (2002) "Downregulation of hypothalamic vasopressinergic hyperdrive is involved in clinically relevant behavioral and neuroendocrine antidepressant drug effects", Neuropsychopharmacology (in press).
13. Kirby, L.G., Rice, K.C. and Valentino, R.J. (2000) "Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus", Neuropsychopharmacology 22, 148-162.
14. Korte, S.M. (2001) "Corticosteroids in relation to fear, anxiety and psychopathology", Neurosci. Biobehav. Rev. 25, 117-142.
15. Landgraf, R. and Wigger, A. (2002) "High vs low anxiety related behaviour rats: An animal model of extremes in trait anxiety", Behav. Genet. 32, 301-314.
16. Landgraf, R., Wigger, A., Holsboer, F. and Neumann, I.D. (1999) "Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behavior", J. Neuroendocrinol. 11, 405-407.
17. Liebsch, G., Linthorst, A.C.E., Neumann, I.D., Reul, J.M.H.M., Holsboer, F. and Landgraf, R. (1998a) "Behavioral, physiological and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior", Neuropsychopharmacology 19, 381-396.
18. Liebsch, G., Montkowski, A., Holsboer, F. and Landgraf, R. (1998b) "Behavioral profiles of two Wistar rat lines selectively bred for high or low anxiety-related behavior", Behav. Brain Res. 94, 301-310.
19. Linthorst, A.C.E., Flachskamm, C., Hopkins, S.J., Hoadley, M.E., Labeur, M.S., Holsboer, F. and Reul, J.M.H.M. (1997) "Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral and cytokine responses to a systemic inflammatory challenge", J. Neuroci. 17, 4448-4460.
20. Lowry, C.A., Rodda, J.E., Lightman, S.L. and Ingram, C.D. (2000) "Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: Evidence for activation of a topographically organized mesolimbocortical serotonergic system", J. Neurosci. 20, 7728-7736.
21. Maes, M. and Meltzer, H.Y. (1995) "The serotonin hypothesis of major depression", In: Bloom, F.E. and Kupfer, D.J., eds, Psychopharmacology: The Fourth Generation of Progress (Raven Press, New York), pp 933-944.
22. McKittrick, C.R. and McEwen, B.S. (1996) "Regulation of serotonergic function in the CNS by steroid hormones and stress", In: Stone, T.W., eds, CNS Neurotransmitters and Neuromodulators (CRC Press, Boca Raton, Florida) 4, pp 37-76.
23. Ohl, F., Toschi, N., Wigger, S., Henniger, M.S. and Landgraf, R. (2001) "Dimensions of emotionality in a rat model of innate anxiety", Behav. Neurosci. 115, 429-436.
24. Paxinos, G. and Watson, C. (1998) The Rat Brain in Stereotaxic Coordinates (Academic Press, Sydney).
25. Penalva, R.G., Flachskamm, C., Zimmermann, S., Wurst, W., Holsboer, F., Reul, J.M.H.M. and Linthorst, A.C.E. (2002) "Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: An in vivo microdialysis study in mutant mice", Neuroscience 109, 253-266.
26. Ressler, K.J. and Nemeroff, C.B. (2000) "Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders", Depress. Anxiety 12, S2-S19.
27. Rueter, L.E. and Jacobs, B.L. (1996) "A microdialysis examination of serotonin release in the forebrain induced by behavioral/environmental manipulations", Brain Res. 739, 57-69.
28. Sawchenko, P.E., Swanson, L.W., Steinbusch, H.W.M. and Verhofstad, A.A.J. (1983) "The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat", Brain Res. 277, 355-360.
29. Singewald, N., Kaehler, S., Hemeida, R. and Philippu, A. (1997) "Release of serotonin in the rat locus coeruleus: Effects of cardiovascular, stressful and noxious stimuli", Eur. J. Neurosci. 9, 556-562.
30. Stein, D.J. and Stahl, S. (2000) "Serotonin and anxiety: Current models", Int. Clin. Psychopharmacol. 15, S1-S6.
31. Takahashi, H., Takada, Y., Nagai, N., Urano, T. and Takada, A. (2000) "Serotonergic neurons projecting to hippocampus activate locomotion", Brain Res. 869, 194-202.
32. 2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells", J. Neurosci. 21, 3572-3579.
33. Wigger, A., Sánchez, M.M., Mathys, K.C., Ebner, K., Liu, D., Kresse, A., Neumann, I.D., Holsboer, F., Plotsky, P.M., Landgraf, R. (2002) "Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin", Neuroscience, (In press).