Colonic epithelial atrophy induced by a fibre-free diet in rats is reversed by minimal amounts of luminal butyrate, but only in the short term

ANZ Journal of Surgery

Volumn 72, Issue 12, 2002, Pages 871-876

  Sengupta, Shomik ^a   Tang, Choong Leong ^a   Wong, Cynthia S M ^a   Tjandra, Joe J ^a   Gibson, Peter R ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b BOX HILL HOSPITAL   (Australia)

Author keywords

Animal disease models; Butyrates; Cell division; Colon; Dietary fibre; Epithelium; Fatty acids; Infusions; Sprague dawley rats

Indexed keywords

BUTYRIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON DISEASE; COLONIC EPITHELIAL ATROPHY; CONTROLLED STUDY; DESCENDING COLON; DIETARY FIBER; DIETARY INTAKE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG INFUSION; INTESTINE CELL; INTESTINE CRYPT; LAPAROTOMY; MITOSIS; NONHUMAN; RAT;

ANIMALS; ATROPHY; BUTYRATES; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; MALE; MUCOUS MEMBRANE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036908357     PISSN: 14451433     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1445-2197.2002.t01-1-02586.x     Document Type: Article

References (42)

1. Lipkin M, Reddy B, Newmark H, Lamprecht SA. Dietary factors in human colorectal cancer. Annu. Rev. Nutr. 1999; 19: 545-86.
2. Szilagyi A. Altered colonic environment, a possible predisposition to colorectal cancer and colonic inflammatory bowel disease: Rationale of dietary manipulation with emphasis on disaccharides. Can. J. Gastroenterol. 1998; 12: 133-46.
3. Hill MJ. Cereals, cereal fibre and colorectal cancer risk: A review of the epidemiological literature. Eur. J. Cancer Prev. 1998; 7: S5-10.
4. Davies PS, Rhodes J. Maintenance of remission in ulcerative colitis with sulphasalazine or a high-fibre diet: A clinical trial. BMJ. 1978; 1: 1524-5.
5. Kritchevsky D. Cereal fibres and colorectal cancer: A search for mechanisms. Eur. J. Cancer Prev. 1998; 7: S33-9.
6. Klurfeld DM. Dietary fiber-mediated mechanisms in carcinogenesis. Cancer Res. 1992; 52: 2055S-9S.
7. Cook SI, Sellin JH. Review article: Short chain fatty acids in health and disease. Aliment Pharmacol. Ther. 1998; 12: 499-507.
8. Young GP, Gibson PR. Butyrate and the human cancer cell. In: Cummings JH, Rombeau J and Sakata T (eds). Physiological and Clinical Aspects of Short Chain Fatty Acids. Cambridge: Cambridge University Press, 1995; Ch. 21.
9. Velazquez OC, Lederer HM, Rombeau JL. Butyrate and the colonocyte: Implications for neoplasia. Dig. Dis. Sci. 1996; 41: 727-39.
10. Archer S, Meng S, Wu J, Johnson J, Tang R, Hodin R. Butyrate inhibits colon carcinoma cell growth through two distinct pathways. Surgery 1998; 124: 248-53.
11. Gibson PR, Moeller I, Kagelari O, Folino M, Young GP. Contrasting effects of butyrate on the expression of phenotypic markers of differentiation in neoplastic and non-neoplastic colonic epithelial cells in vitro. J. Gastroenterol. Hepatol. 1992; 7: 165-72.
12. Sakata T. Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: A possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors. Br. J. Nutr. 1987; 58: 95-103.
13. Kripke SA, Fox AD, Berman JM, Settle RG, Rombeau JL. Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids. JPEN J. Parenter. Enteral. Nutr. 1989; 13: 109-16.
14. Kissmeyer-Nielsen P, Mortensen FV, Laurberg S, Hessov I. Transmural trophic effect of short chain fatty acid infusions on atrophic, defunctioned rat colon. Dis. Colon Rectum 1995; 38: 946-51.
15. Ichikawa H, Sakata T. Stimulation of epithelial cell proliferation of isolated distal colon of rats by continuous colonic infusion of ammonia or short-chain fatty acids is nonadditive. J. Nutr. 1998; 128: 843-7.
16. Scheppach W, Sommer H, Kirchner T et al. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 1992; 103: 51-6.
17. Bartram HP, Englert S, Scheppach W et al. Antagonistic effects of deoxycholic acid and butyrate on epithelial cell proliferation in the proximal and distal human colon. Z. Gastroenterol. 1994; 32: 389-92.
18. Gibson PR, Kilias D, Rosella O et al. Effect of topical butyrate on rectal epithelial kinetics and mucosal enzyme activities. Clin. Sci. Colch. 1998; 94: 671-6.
19. Roediger WE. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 1982; 83: 424-9.
20. Tang CL, Ling BC, Fielding M, Tjandra JJ, Gibson PR. Cecal intubation model in the rat that facilitates selective in vivo study of colonic epithelial biology preliminary report. Dis. Colon Rectum 1998; 41: 1500-5.
21. Tang CL, Wong CSM, Sengupta S, Tjandra JJ, Gibson PR. Development of a chronic colonic intubation model in rats for the study of luminal factors in colonic diseases. Dis. Colon Rectum 2001; 44: 256-63.
22. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 1993; 123: 1939-51.
23. D'Argenio G, Cosenza V, Cave MD et al. Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model. Gastroenterology 1996; 110: 1727-34.
24. Folino M, McIntyre A, Young GP. Dietary fibers differ in their effects on large bowel epithelial proliferation and fecal fermentation-dependent events in rats. J. Nutr. 1995; 125: 1521-8.
25. Lupton JR, Kurtz PP. Relationship of colonic luminal short-chain fatty acids and pH to in vivo cell proliferation in rats. J. Nutr. 1993; 123: 1522-30.
26. Hass R, Busche R, Luciano L, Reale E, Engelhardt WV. Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig. Gastroenterology 1997; 112: 875-81.
27. Sakata T. Stimulatory effect of short-chain fatty acids on epithelial cell proliferation of isolated and denervated jejunal segment of the rat. Scand. J. Gastroenterol. 1989; 24: 886-90.
28. Hague A, Butt AJ, Paraskeva C. The role of butyrate in human colonic epithelial cells: An energy source or inducer of differentiation and apoptosis? Proc. Nutr. Soc. 1996; 55: 937-43.
29. Wong CSM. The mechanisms by which dietary fibre influences the early events of colon carcinogenesis. In: Department of Medicine. Parkville: University of Melbourne, 2001; Ch. 5.
30. Mariadason JM, Catto-Smith A, Gibson PR. Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats. Gut 1999; 44: 394-9.
31. Cassidy MM, Lightfoot FG, Grau LE, Story JA, Kritchevsky D, Vahouny GV. Effect of chronic intake of dietary fibers on the ultrastructural topography of rat jejunum and colon: A scanning electron microscopy study. Am. J. Clin. Nutr. 1981; 34: 218-28.
32. Govers MJ, Gannon NJ, Dunshea FR, Gibson PR, Muir JG. Wheat bran affects the site of fermentation of resistant starch and luminal indexes related to colon cancer risk: A study in pigs. Gut 1999; 45: 840-7.
33. Velazquez OC, Lederer HM, Rombeau JL. Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications. Adv. Exp. Med. Biol. 1997; 427: 123-34.
34. Rolandelli RH, Koruda MJ, Settle RG, Rombeau JL. Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat. Surgery 1986; 100: 198-204.
35. Binderow SR, Cohen SM, Wexner SD, Nogueras JJ. Must early postoperative oral intake be limited to laparoscopy? Dis. Colon Rectum 1994; 37: 584-9.
36. Ortiz H, Armendariz P, Yarnoz C. Is early postoperative feeding feasible in elective colon and rectal surgery? Int. J. Colorectal Dis 1996; 11: 119-21.
37. Rolandelli RH, Buckmire MA, Bernstein KA. Intravenous butyrate and healing of colonic anastomoses in the rat. Dis. Colon Rectum 1997; 40: 67-70.
38. Edwards CM, George B, Warren B. Diversion colitis - New light through old windows. Histopathology 1999; 34: 1-5.
39. Harig JM, Soergel KH, Komorowski RA, Wood CM. Treatment of diversion colitis with short-chain-fatty acid irrigation. N. Engl. J. Med. 1989; 320: 23-8.
40. Guillemot F, Colombel JF, Neut C et al. Treatment of diversion colitis by short-chain fatty acids. Prospective and double-blind study. Dis. Colon Rectum 1991; 34: 861-4.
41. Mortensen FV, Hessov I, Birke H, Korsgaard N, Nielsen H. Microcirculatory and trophic effects of short chain fatty acids in the human rectum after Hartmann's procedure. Br. J. Surg. 1991; 78: 1208-11.
42. Mariadason JM, Kilias D, Catto-Smith A, Gibson PR. Effect of butyrate on paracellular permeability in rat distal colonic mucosa ex vivo. J. Gastroenterol. Hepatol. 1999; 14: 873-9.