Resistance-training-induced adaptations in skeletal muscle protein turnover in the fed state

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 11, 2002, Pages 1045-1053

  Phillips, S M ^a   Parise, G ^a   Roy, B D ^b   Tipton, K D ^c   Wolfe, R R ^c   Tarnopolsky, M A ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Hypertrophy; Myofibrillar protein; Protein breakdown; Protein synthesis

Indexed keywords

CREATINE; GLUCOSE; INSULIN; MUSCLE PROTEIN; NITROGEN 15; PHENYLALANINE;

ADAPTATION; ADULT; ARTICLE; CALCULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEEDING; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN BLOOD LEVEL; LEG EXERCISE; LONGITUDINAL STUDY; MALE; MUSCLE BIOPSY; MUSCLE MASS; MUSCLE STRENGTH; MUSCLE TRAINING; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; REST; SKELETAL MUSCLE; TASK PERFORMANCE;

ADULT; ANALYSIS OF VARIANCE; DOUBLE-BLIND METHOD; EXERCISE; FOOD; HUMANS; LONGITUDINAL STUDIES; MALE; MUSCLE, SKELETAL; WEIGHT LIFTING;

EID: 0036906223     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-134     Document Type: Article

References (33)

1. Alway, S.E., Grumbt, W.H., Stray-Gundersen, J., and Gonyea, W.J. 1992. Effects of resistance training on elbow flexors of highly competitive bodybuilders. J. Appl. Physiol. 72: 1512-1521.
2. Balagopal, P., Rooyackers, O.E., Adey, D.B., Ades, P.A., and Nair, K.S. 1997. Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am. J. Physiol. 273: E790-E800.
3. Baldwin, K.M., and Haddad, F. 2001. Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle. J. Appl. Physiol. 90: 345-357.
4. Biolo, G., Maggi, S.P., Williams, B.D., Tipton, K.D., and Wolfe, R.R. 1995. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am. J. Physiol. 268: E514-E520.
5. Biolo, G., Tipton, K.D., Klein, S., and Wolfe, R.R. 1997. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am. J. Physiol. 273: E122-E129.
6. Biolo, G., Williams, B.D., Fleming, R.Y., and Wolfe, R.R. 1999. Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise. Diabetes, 48: 949-957.
7. Bohe, J., Low, J.F., Wolfe, R.R., and Rennie, M.J. 2001. Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids. J. Physiol. (Lond.), 532: 575-579.
8. Caso, G., Ford, G.C., Nair, K.S., Vosswinkel, J.A., Garlick, P.J., and McNurlan, M.A. 2001. Increased concentration of tracee affects estimates of muscle protein synthesis. Am. J. Physiol. 280: E937-E946.
9. Chesley, A., MacDougall, J.D., Tarnopolsky, M.A., Atkinson, S.A., and Smith, K. 1992. Changes in human muscle protein synthesis after resistance exercise. J. Appl. Physiol. 73: 1383-1388.
10. Dangott, B., Schultz, E., and Mozdziak, P.E. 2000. Dietary creatine monohydrate supplementation increases satellite cell mitotic activity during compensatory hypertrophy. Int. J. Sports Med. 21: 13-16.
11. Earnest, C.P., Snell, P.G., Rodriguez, R., Almada, A.L., and Mitchell, T.L. 1995. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol. Scand. 153: 207-209.
12. Farrell, P.A., Fedele, M.J., Hernandez, J., Fluckey, J.D., Miller, J.L., III, Lang, C.H., Vary, T.C., Kimball, S.R., and Jefferson, L.S. 1999. Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise. J. Appl. Physiol. 87: 1075-1082.
13. Gelfand, R.A., and Barrett, E.J. 1987. Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J. Clin. Invest. 80: 1-6.
14. Harris, R.C., Soderlund, K., and Hultman, E. 1992. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. 83: 367-374.
15. Hasten, D.L., Pak-Loduca, J., Obert, K.A., and Yarasheski, K.E. 2000. Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds. Am. J. Physiol. Endocrinol. Metab. 278: E620-E626.
16. Ingwall, J.S., Weiner, C.D., Morales, M.F., Davis, E., and Stockdale, F.E. 1974. Specificity of creatine in the control of muscle protein synthesis. J. Cell. Biol. 62: 145-151.
17. MacDougall, J.D., Gibala, M.J., Tarnopolsky, M.A., MacDonald, J.R., Interisano, S.A., and Yarasheski, K.E. 1995. The time course for elevated muscle protein synthesis following heavy resistance exercise. Can. J. Appl. Physiol. 20: 480-486.
18. Parise, G., Mihic, S., MacLennan, D., Yarasheski, K.E., and Tarnopolsky, M.A. 2001. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed muscle protein synthesis. J. Appl. Physiol. 91: 1041-1047.
19. Phillips, S.M., Tipton, K.D., Aarsland, A., Wolf, S.E., and Wolfe, R.R. 1997. Mixed muscle protein synthesis and breakdown following resistance exercise in humans. Am. J. Physiol. 273: E99-E107.
20. Phillips, S.M., Tipton, K.D., Ferrando, A.A., and Wolfe, R.R. 1999. Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am. J. Physiol. 276: E118-E124.
21. Rasmussen, B.B., Tipton, K.D., Miller, S.L., Wolf, S.E., and Wolfe, R.R. 2000. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J. Appl. Physiol. 88: 386-392.
22. Rooyackers, O.E., Adey, D.B., Ades, P.A., and Nair, K.S. 1996. Effect of age on in vivo rates of mitochondrial protein synthess in human skeletal muscle. Proc. Natl. Acad. Sci. U.S.A. 93: 15 364-15 369.
23. Sale, D.G. 1992. Neural adaptation to resistance training. Med. Sci. Sports Exerc. 20: S135-S145.
24. Sipila, I., Rapola, J., Simell, O., and Vannas, A. 1981. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N. Engl. J. Med. 304: 867-870.
25. Sultan, K.R., Dittrich, B.T., Leisner, E., Paul, N., and Pette, D. 2001. Fiber type-specific expression of major proteolytic systems in fast- to slow-transforming rabbit muscle. Am. J. Physiol. Cell Physiol. 280: C239-C247.
26. Tarnopolsky, M.A., Parise, G., Yardley, N.J., Ballantyne, C.B., Olatunji, S., and Phillips, S.M. 2001. Creatine-dextrose and protein-dextrose induce similar strength gains during training. Med. Sci. Sports Exerc. 33: 2044-2052.
27. Tipton, K.D., Ferrando, A.A., Phillips, S.M., Doyle, D.J., and Wolfe, R.R. 1999. Postexercise net protein synthesis in human muscle from orally administered amino acids. Am. J. Physiol. 276: E628-E634.
28. Tipton, K.D., Rasmussen, B.B., Miller, S.L., Wolf, S.E., Owens-Stovall, S.K., Petrini, B.E., and Wolfe, R.R. 2001. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am. J. Physiol. Endocrinol. Metab. 281: E197-E206.
29. Volek, J.S., Duncan, N.D., Mazzetti, S.A., Staron, R.S., Putukian, M., Gomez, A.L., Pearson, D.R., Fink, W.J., and Kraemer, W.J. 1999. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med. Sci. Sports Exerc. 31: 1147-1156.
30. Welle, S., Bhatt, K., and Thornton, C.A. 1999. Stimulation of myofibrillar synthesis by exercise is mediated by more efficient translation of mRNA. J. Appl. Physiol. 86: 1220-1225.
31. Willoughby, D.S., and Rosene, J. 2001. Effects of oral creatine and resistance training on myosin heavy chain expression. Med. Sci. Sports Exerc. 33: 1674-1681.
32. Yarasheski, K.E., Zachwieja, J.F., and Bier, D.M. 1993. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am. J. Physiol. 265: E210-E214.
33. Zhang, X.-J., Chinkes, D.L., Sakurai, Y., and Wolfe, R.R. 1996. An isotopic method for measurement of muscle protein fractional breakdown rate in vivo. Am. J. Physiol. 270: E759-E767.