Progesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies

Obstetrics and Gynecology

Volumn 95, Issue 2, 2000, Pages 227-231

  Phipps, Maureen Glennon ^a   Hogan, Joseph W ^b   Peipert, Jeffrey F ^c   Lambert Messerlian, Geralyn M ^c   Canick, Jacob A ^c   Seifer, David B ^d  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b BROWN UNIVERSITY   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

^d UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHORIONIC GONADOTROPIN; INHIBIN; INHIBIN A; PROGESTERONE;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; FETUS DEVELOPMENT; FIRST TRIMESTER PREGNANCY; HUMAN; MAJOR CLINICAL STUDY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; STATISTICS;

ADULT; BIOLOGICAL MARKERS; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; COHORT STUDIES; FEMALE; FETAL VIABILITY; HUMANS; INHIBINS; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, FIRST; PROGESTERONE; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 0033954688     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0029-7844(99)00480-9     Document Type: Article

References (14)

1. Grosskinsky C.M., Hage M.L., Tyrey L., Christakos A.C., Hughes C.L. hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy. Obstet Gynecol. 81:1993;705-709.
2. Ness R.B., McLaughlin M.T., Heine R.P., Bass D.C., Mortimer L. Fetal fibronectin as a biomarker to discriminate between ectopic and intrauterine pregnancies. Am J Obstet Gynecol. 179:1998;697-702.
3. Seifer D.B., Lambert-Messerlian G.M., Canick J.A., Frishman G.N., Schneyer A.L. Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies. Fertil Steril. 65:1996;667-669.
4. Stovall T.G., Ling F.W., Andersen R.N., Buster J.E. Improved sensitivity and specificity of a single measurement of serum progesterone over serial quantitative beta-human chorionic gonadotropin in screening for ectopic pregnancy. Hum Reprod. 7:1992;723-725.
5. Cowan B.D., Vandermolen D.T., Long C.A., Whitworth N.S. Receiver-operator characteristic, efficiency analysis, and predictive value of serum progesterone concentration as a test for abnormal gestations. Am J Obstet Gynecol. 166:1992;1729-1737.
6. McCord M.L., Muram D., Buster J.E., Arheart K.L., Stovall T.G., Carson S.A. Single serum progesterone as a screen for ectopic pregnancy Exchanging specificity and sensitivity to obtain optimal test performance . Fertil Steril. 66:1996;513-516.
7. Dart R., Dart L., Segal M., Page C., Brancato J. The ability of a single serum progesterone to identify abnormal pregnancies in patients with beta-human chorionic gonadotropin values less than 1,000 mIU/mL. Acad Emerg Med. 5:1998;304-309.
8. D'Antona D., Mamers P.M., Lowe P.J.M., Balazs N., Groome N.P., Wallace E.M. Evaluation of serum inhibin-A as a surveillance biomarker after conservative management of tubal pregnancy. Hum Reprod. 12:1998;2305-2307.
9. Cole L.A., Kardana A., Seifer D.B., Bohler H.C.L. Urine hCG β-subunit core fragment, a sensitive test for ectopic pregnancy. J Clin Endocrinol Metab. 78:1994;497-499.
10. Haddow J.E., Palomaki G.E., Knight G.J., Williams J., Miller W.A., Johnson A. Screening of maternal serum for fetal Down's syndrome in the first trimester. N Engl J Med. 338:1998;955-961.
11. Crowder M.J., Hand D.J. Analysis of repeated measures. 1st ed. 1990;Chapman & Hall, London.
12. Agresti A. Categorical data analysis. 1990;Wiley & Sons, New York.
13. Irwig L. Modeling result-specific likelihood ratios. J Clin Epidemiol. 45:1992;1335-1336.
14. Speroff L., Glass R.H., Kase N.G. Clinical gynecologic endocrinology and infertility. 5th ed. 1994;Williams & Wilkins, Baltimore.