Prolonged depletion of guanosine triphosphate induces death of insulin- secreting cells by apoptosis

Endocrinology

Volumn 139, Issue 9, 1998, Pages 3752-3762

  Li, Guodong ^a,b,c   Segu, Venkatesh Babu G ^a   Rabaglia, Mary E ^a   Luo, Rui Hua ^b,c   Kowluru, Anjaneyulu ^a,e   Metz, Stewart A ^a,d,e  

^a WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^e DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; GUANOSINE TRIPHOSPHATE; INOSINATE DEHYDROGENASE; MEVINOLIN; MIZORIBINE; MYCOPHENOLIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; DNA BINDING; ELECTRON MICROSCOPY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; INSULIN RELEASE; NONHUMAN; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN PROCESSING; RAT; SIGNAL TRANSDUCTION;

EID: 0031730108     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.9.6207     Document Type: Article

References (76)

1. Wyllie AH, Kerr JF, Currie AR 1980 Cell death: the significance of apoptosis. Int Rev Cytol 68:251-306
2. Collins MK, Lopez Rivas A 1993 The control of apoptosis in mammalian cells. Trends Biochem Sci 18:307-309
3. Metz SA, Rabaglia ME, Pinlar TJ 1992 Selective inhibitors of GTP synthesis impede exocytotic insulin release from intact rat islets. J Biol Chem 267:12517-12527
4. Metz SA, Meredith M, Rabaglia ME, Kowluru A 1993 Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5′-triphosphate in rat islets. J Clin Invest 92:872-882
5. Metz SA, Rabaglia ME, Stock JB, Kowluru A 1993 Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. Biochem J 295:31-40
6. Kowluru A, Rabaglia ME, Muse KE, Metz SA 1994 Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells. Biochim Biophys Acta 1222:348-359
7. Meredith M, Rabaglia ME, Metz SA 1995 Evidence of a role for GTP in the potentiation of Ca(2+)-induced insulin secretion by glucose in intact rat islets. J Clin Invest 96:811-821
8. Vadakekalam J, Rabaglia ME, Chen QH, Metz SA 1996 Glucose-induced phosphoinositide hydrolysis: a requirement for GTP in calcium-induced phospholipase C activation in pancreatic islets. Am J Physiol 271:E85-E95
9. Meredith M, Li GD, Metz SA 1997 Inhibition of calcium-induced insulin secretion from intact HIT-T15 or INS-1 β cells by GTP depletion. Biochem Pharmacol 53:1873-1882
10. Allison AC, Eugui EM 1993 Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 136:5-28
11. Allison AC, Eugui EM 1994 Preferential suppression of lymphocyte proliferation by mycophenolic acid and predicted long-term effects of mycophenolate mofetil in transplantation. Transplant Proc 26:3205-3210
12. Sandler S, Sandberg JO, Andersson A 1994 RS-61443-induced glucose intolerance in mice. Transplant Proc 26:741-742
13. Sandberg JO, Andersson A, Sandler S 1993 Exposure of rat pancreatic islets to RS-61443 inhibits beta-cell function. Transplantation 56:1197-1201
14. Sollinger HW, Deierhoi MH, Belzer FO, Diethelm AG, Kauffman RS 1992 RS-61443-a phase I clinical trial and pilot rescue study. Transplantation 53:428-432
15. Morris RE, Wang J, Blum JR, Flavin T, Murphy MP, Almquist SJ, Chu N, Tam YL, Kaloostian M, Allison AC, Eugui EM 1991 Immunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allografts. Transplant Proc [Suppl 2] 23:19-25
16. Li GD, Rungger-Brandle E, Just I, Jonas JC, Aktories K, Wollheim CB 1994 Effect of disruption of actin filaments by clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets. Mol Biol Cell 5:1199-1213
17. Asfari M, Janjic D, Meda P, Li GD, Halban PA, Wollheim CB 1992 Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178
18. Segu, VBG, Li GD, Metz SA 1998 Use of a soluble tetrazolium compound to assay metabolic activation of intact β cells. Metabolism 47:824-830
19. Cory AH, Owen TC, Barltrop JA, Cory JG 1991 Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun 3:207-212
20. Janjic D, Wollheim CB 1992 Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 35:482-485
21. Loweth AC, Williams GT, Scarpello JHB, Moran NG 1996 Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic β-cells. Exp Cell Res 229:69-76
22. Wyllie AH, Morris RG, Smith AL, Dunlop D 1984 Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 142:67-77
23. Dowd DR 1995 Calcium regulation of apoptosis. Adv Second Messenger Phosphoprotein Res 30:255-280
24. Batistatou A, Greene LA 1991 Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J Cell Biol 115:461-471
25. Lucas M, Sanchez-Margalet V 1995 Protein kinase C involvement in apoptosis. Gen Pharmacol 26:881-887
26. Takai Y, Kaibuchi K, Kikuchi A, Kawata M 1992 Small GTP-binding proteins. Int Rev Cytol 133:187-230
27. Kowluru A, Seavey SE, Li GD, Sorenson RL, Weinhaus AJ, Nesher R, Rabaglia M, Vadakekalam J, Metz SA 1996 Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure β cells: evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. J Clin Invest 98:540-555
28. Kowluru A, Li GD, Metz SA 1997 Glucose activates the carboxyl methylation of γ subunits of trimeric GTP-binding proteins in pancreatic β cells. J Clin Invest 100:1596-1610
29. Li GD, Regazzi R, Roche E, Wollheim CB 1993 Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells, probable involvement of small GTP-binding proteins. Biochem J 289:379-385
30. Moorman JP, Bobak DA, Hahn CS 1996 Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4. J Immunol 156:4146-4153
31. Moorman J, Gilmer L, Hahn C, Bobak D 1996 Inactivation of the small G-protein Rho disrupts cellular adhesion and spreading and activates apoptosis. J Invest Med 44:240A
32. Lacal JC 1997 Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling. FEBS Lett 410:73-77
33. Jimenez B, Arends M, Esteve P, Perona R, Sanchez R, Cajal SR, Wyllie A, Lacal JC 1995 Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of Rho-p21, a GTPase protein of the Ras superfamily. Oncogene 10:811-816
34. Fiorentini C, Fabbri A, Matarrese P, Falzano L, Boquet P, Malorni W 1997 Hinderance of apoptosis and phagocytic behaviour induced by Escherichia coli cytotoxic necrotizing factor 1: two related activities in epithelial cells. Biochem Biophys Res Commun 241:341-346
35. Ghosh PM, Mott GE, Ghosh-Choudhury N, Radnik RA, Stapleton ML, Ghidoni JJ, Kreisberg JI 1997 Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. Biochim Biophys Acta 1359:13-24
36. Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories K 1995 Glucosylation of rho proteins by clostridium difficile toxin B. Nature 375:500-503
37. Olson MF, Ashworth A, Hall A 1995 An essential role for Rho, Rac, and CDC42 GTPases in cell cycle progression through G1. Science 269:1270-1274
38. Barres BA, Hart IK, Coles HSR, Burne JF, Voyvodic JT, Richardson WD, Raff MC 1992 Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70:31-46
39. Ishida Y, Agata Y, Shibahara K, Honjo T 1992 Induced expression of pd-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 11:3887-3895
40. Vitale M, Zamai L, Falcieri E, Zauli G, Gobbi P, Santi S, Cinti C, Weber G 1997 IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells. Cytometry 30:61-66
41. Nguyen BT, Sadee W 1986 Compartmentation of guanine nucleotide precursors for DNA synthesis. Biochem J 234:263-269
42. Yoshioka A, Tanaka S, Hiraoka O, Koyama Y, Ayusawa D, Seno T, Garrett C, Wataya Y 1987 Deoxyribonucleoside trisphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J Biol Chem 262:8235-8241
43. Huang P, Plunkett W 1997 Induction of apoptosis by gemcitabine. Semin Oncol 22:19-25
44. Cohen MB, Maybaum J, Sadee W 1981 Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells. J Biol Chem 256:8713-8717
45. Catapano CV, Dayton JS, Mitchell BS, Fernandes DJ 1995 GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. Mol Pharmacol 47:948-955
46. Sherley JL 1991 Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration. J Biol Chem 266:24815-24828
47. Liu Y, Bohn SA, Sherley JL 1998 Inosine-5′-monophosphate dehydrogenase is a rate determining factor for p53-dependent growth regulation. Mol Biol Cell 9:15-28
48. Selivanova G, Iotsova V, Okan I, Fritsche M, Ström M, Groner B, Grafström RC, Wiman KG 1997 Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat Med 3:632-638
49. Dunlop D, Metz SA, Clark S 1995 Guanine nucleotide-dependent β-cell replication by phospholipase D and A2 products. In: Baba S, Kaneko T (eds) Diabetes 1994. Elsevier, Amsterdam, pp 198-202
50. Duan D-S, Sadee W 1987 Distinct effects of adenine and guanine starvation on DNA synthesis associated with different pool size of nucleotide precursors. Cancer Res 47:4047-4051
51. Plagemann PGW 1971 Nucleoside transport by Novikoff rat hepatoma cells growing in suspension culture. Specificity and mechanism of transport reaction and relationship to nucleoside incorporation into nucleic acids. Biochim Biophys Acta 233:688-701
52. Mitchell BS, Kelley WN 1980 Purinogenic immunodeficiency diseases: clinical features and molecular mechanisms. Ann Intern Med 92:826-831
53. Van GM, Lin SZ, Irwin RP, Paul SM 1995 Activation of G proteins directionally affects apoptosis of cultured cerebellar granule neurons. J Neurochem 65:2425-2431
54. Yan GM, Lin SZ, Irwin RP, Paul SM 1995 Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol Pharmacol 47:248-257
55. Chen CY, Faller DV 1995 Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene 11:1487-1498
56. h: a GTP-binding protein with transglutaminase activity and receptor signaling function. Science 264:1593-1596
57. Tarcsa E, Kedei N, Thomazy V, Fesus L 1992 An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis. J Biol Chem 267:25648-25651
58. Lindsay MA, Bungay PJ, Griffin M 1990 Transglutaminase involvement in the secretion of insulin from electropermeabilized rat islets of Langerhans. Biosci Rep 10:557-561
59. Spaargaren M, Bischoff JR, McCormick F 1995 Signal transduction by ras-like GTPases: a potential target for anticancer drugs. Gene Expr 4:345-356
60. Chuang TH, Hahn KM, Lee JD, Danley DE, Bokoch GM 1997 The small GTPase CDC42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Mol Biol Cell 8:1687-1698
61. Hata U, Natsumeda Y, Weber G 1993 Tiazofurin decreases Ras-GTP complex in K562 cells. Oncol Res 5:161-164
62. 2/prophase of the first meiotic cell cycle and in prevention of apoptosis. EMBO J 16:5550-5561
63. Jones KD, Couldwell WT, Hinton DR, Su Y, He S, Anker L, Law RE 1994 Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells. Biochem Biophys Res Commun 205:1681-1687
64. Perez-Sala D, Collado-Escobar D, Mollinedo F 1995 Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem 270:6235-6242
65. Reedquist KA, Pope TK, Roess DA 1995 Lovastatin inhibits proliferation and differentiation and causes apoptosis in lipopolysaccharide-stimulated murine B cells. Biochem Biophys Res Commun 211:665-670
66. Patterson SD, Grossman JS, D'Andrea P, Latter GI 1995 Reduced numatrin/ b23/nucleophosmin labeling in apoptotic jurkat T-lymphoblasts. J Biol Chem 270:9429-9436
67. Borner MM, Myers CE, Sartor O, Sei Y, Toko T, Trepel JB, Schneider E 1995 Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line pc-3. Cancer Res 55:2122-2128
68. Marcelli M, Cunningham GR, Haidacher SJ, Padayatty SJ, Sturgis L, Kagan C, Denner L 1998 Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res 58:76-83
69. Iimura O, Vrtovsnik F, Terzi F, Friedlander G 1997 HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Kidney Int 52:962-972
70. European Mycophenolate Mofetil Cooperative Study Group 1995 Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. European mycophenolate mofetil cooperative study group. Lancet 345:1321-1325
71. Teitelman G 1993 On the origin of pancreatic endocrine cells, proliferation and neoplastic transformation. Tumor Biol 14:167-173
72. Morgan NG, Cable HC, Newcombe NR, Williams GT 1994 Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis. Biosci Rep 14:243-250
73. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS 1998 Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat. Diabetes 47:358-364
74. 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DlSlA damage. Genes Dev 10:934-947
75. Meredith M, Rabaglia ME, Corbett JA, Metz SA 1996 Dual functional effects of interleukin-1β on purine nucleotides and insulin secretion in rat islets and INS-1 cells. Diabetes 45:1783-1791
76. Dunger A, Augstein P, Schmidt S, Fischer U 1996 Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA. J Autoimmun 9:309-313