Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

British Journal of Clinical Pharmacology

Volumn 54, Issue 6, 2002, Pages 643-651

  Wanwimolruk, Sompon ^a,b   Paine, Mary F ^a,b   Pusek, Susan N ^a,b   Watkins, Paul B ^a,b,c  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

Author keywords

CYP3A4; In vivo; Metabolism; Pharmacokinetics; Probe; Quinine

Indexed keywords

3 HYDROXYQUININE; ANTIMALARIAL AGENT; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DRUG METABOLITE; DRUG METABOLIZING ENZYME; ERYTHROMYCIN; LIVER ENZYME; QUININE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BREATH ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; AGED; ANTIMALARIALS; AREA UNDER CURVE; BREATH TESTS; CROSS-OVER STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROMYCIN; FEMALE; HUMANS; LIVER; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MOLECULAR PROBES; OVARIAN NEOPLASMS; QUINIDINE; QUININE; TROLEANDOMYCIN;

EID: 0036903698     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2002.01687.x     Document Type: Article

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