Relation between MDR1 mRNA levels, resistance factor, and the efficiency of P-glycoprotein-mediated efflux of pirarubicin in multidrug-resistant K562 sublines

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 11, 2002, Pages 1054-1063

  Meesungnoen, Jintana ^a,b   Jay Gerin, Jean Paul ^b   Mankhetkorn, Samlee ^a  

^a BURAPHA UNIVERSITY   (Thailand)

^b UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Acidic organelles; Fluorescence spectroscopy; Kinetic parameters; MDR1 mRNA levels; Multidrug resistance; P glycoprotein; Pirarubicin

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PIRARUBICIN; POTASSIUM PROTON EXCHANGE PROTEIN;

ACIDIFICATION; ARTICLE; CELL COUNT; CELL ORGANELLE; CELL PH; CELL SELECTION; CELL STRAIN K 562; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG TARGETING; DRUG TRANSPORT; HUMAN; HUMAN CELL; IC 50; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; R FACTOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECTROFLUOROMETRY; TRANSPORT KINETICS;

DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; P-GLYCOPROTEIN; RNA, MESSENGER;

EID: 0036902448     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-132     Document Type: Article

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