The differential effects of midazolam and diazepam on intracellular Ca2+ transients and contraction in adult rat ventricular myocytes

Anesthesia and Analgesia

Volumn 95, Issue 6, 2002, Pages 1637-1644

  Kanaya, Noriaki ^a,b   Murray, Paul A ^a   Damron, Derek S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; DIAZEPAM; FURA 2 ACETOXYMETHYL ESTER; MIDAZOLAM;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEART CONTRACTION; HEART EXCITATION; HEART MUSCLE CELL; INOTROPISM; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0036895682     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200212000-00030     Document Type: Article

References (17)

1. Reves JG, Fragen RJ, Vinik HR, Greenblatt DJ. Midazolam: Pharmacology and uses. Anesthesiology 1985;62:310-24.
2. Samuelson PN, Reves JG, Kouchoukos NT, et al. Hemodynamic responses to anesthetic induction with midazolam or diazepam in patients with ischemic heart disease. Anesth Analg 1981;60:802-9.
3. Jones DJ, Stehling LC, Zauder HL. Cardiovascular responses to diazepam and midazolam maleate in the dog. Anesthesiology 1979;51:430-4.
4. Vatner SF. Effects of anesthesia on cardiovascular control mechanisms. Environ Health Perspect 1978;26:193-206.
5. Gelissen HPMM, Epema AH, Henning RH, et al. Inotropic effects of propofol, thiopental, midazolam, etomidate, and ketamine on isolated human atrial muscle. Anesthesiology 1996;84:397-403.
6. Reves JG, Kissin I, Fournier S. Negative inotropic effects of midazolam. Anesthesiology 1984;60:517-8.
7. Saegusa K, Furukawa Y, Ogiwara Y, et al. Pharmacologic basis of responses to midazolam in the isolated, cross-perfused, canine right atrium. Anesth Analg 1987;66:711-8.
8. Stowe DF, Bosnjak ZJ, Kampine JP. Comparison of etomidate, ketamine, midazolam, propofol, and thiopental on function and metabolism of isolated hearts. Anesth Analg 1992;74:547-58.
9. Buljubasic N, Marijic J, Berczi V, et al. Differential effects of etomidate, propofol, and midazolam on calcium and potassium channel currents in canine myocardial cells. Anesthesiology 1996;85:1092-9.
10. Nakae Y, Kanaya N, Namiki A. The direct effects of diazepam and midazolam on myocardial depression in cultured rat ventricular myocytes. Anesth Analg 1997;85:729-33.
11. Baum VC, Palmisano BW. The immature heart and anesthesia. Anesthesiology 1997;87:1529-48.
12. 2+ transients and contraction in rat ventricular myocytes at supraclinical concentrations. Anesthesiology 1998;88:781-91.
13. + exchange in rat ventricular myocytes. Anesthesiology 2001;94:1096-104.
14. Gelman S, Reves JG, Harris D. Circulatory responses to midazolam anesthesia: Emphasis on canine splanchnic circulation. Anesth Analg 1983;62:135-9.
15. Wheeler DM, Katz A, Rice T, Hansford RG. Volatile anesthetic effects on sarcoplasmic reticulum content and sarcolemmal calcium flux in isolated rat cardiac cell suspensions. Anesthesiology 1994;80:372-82.
16. 2+ depletes sarcoplasmic reticulum in intact cardiac myocytes. Am J Physiol 1993;265:H517-22.
17. Klotz U, Antonin H, Bieck PR. Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat. J Pharmacol Exp Ther 1976;199:67-73.