In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain

Endocrinology

Volumn 143, Issue 12, 2002, Pages 4820-4827

  Blais, Véronique ^a   Zhang, Ji ^a   Rivest, Serge ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CORTICOSTERONE; CYTOKINE; DIMETHYL SULFOXIDE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KETOROLAC; MESSENGER RNA; MIFEPRISTONE; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GENE EXPRESSION; IMMUNE SYSTEM; IN SITU HYBRIDIZATION; INFLAMMATION; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; RAT;

ADRENAL GLANDS; ANIMALS; BRAIN; CHEMOKINE CCL2; CORTICOSTERONE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FEEDBACK; GENE EXPRESSION; GLUCOCORTICOIDS; HYPOTHALAMUS; I-KAPPA B PROTEINS; IMMUNITY; INFLAMMATION; INTERLEUKIN-1; ISOENZYMES; KETOROLAC; MALE; MICROCIRCULATION; MIFEPRISTONE; PITUITARY GLAND; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036893644     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220598     Document Type: Article

References (24)

1. Bjorkman D 1998 Nonsteroidal anti-inflammatory drug-associated toxicity of the liver, lower gastrointestinal tract, and esophagus. Am J Med 105:17S-21S
2. Giovannucci E, Egan KM, Hunter DJ, Stampfer MJ, Colditz GA, Willett WC, Speizer FE 1995 Aspirin and the risk of colorectal cancer in women. N Engl J Med 333:609-614
3. Williams CS, Smalley W, DuBois RN 1997 Aspirin use and potential mechanisms for colorectal cancer prevention. J Clin Invest 100:1325-1329
4. McGeer PL, McGeer EG 1996 Anti-inflammatory drugs in the fight against Alzheimer's disease. Ann NY Acad Sci 777:213-220
5. Kopp E, Ghosh S 1994 Inhibition of NF-κB by sodium salicylate and aspirin. Science 265:956-959
6. Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA 1997 Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406-3410
7. Minghetti L, Polazzi E, Nicolini A, Creminon C, Levi G 1997 Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs. Eur J Neurosci 9:934-940
8. Meade EA, McIntyre TM, Zimmerman GA, Prescott SM 1999 Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. J Biol Chem 274:8328-8334
9. Yuan CJ, Mandal AK, Zhang Z, Mukherjee AB 2000 Transcriptional regulation of cydooxygenase-2 gene expression: Novel effects of nonsteroidal anti-inflammatory drugs. Cancer Res 60:1084-1091
10. Xu XM, Sansores-Garcia L, Chen XM, Matijevic-Aleksic N, Du M, Wu KK 1999 Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. Proc Natl Acad Sci USA 96:5292-5297
11. Staels B, Koenig W, Habib A, Merval R, Lebret M, Torra IP, Delerive P, Fadel A, Chinetti G, Fruchart JC, Najib J, Maclouf J, Tedgui A 1998 Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature 393:790-793
12. Zhang J, Rivest S 2000 A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1β. J Neurochem 74:2134-2145
13. Blais V, Rivest S 2001 Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-κB activity and COX-2 transcription in the endothelium of the brain capillaries. J Neuropathol Exp Neurol 60:893-905
14. Lacroix S, Rivest S 1998 Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain. J Neurochem 70:452-466
15. Laflamme N, Rivest S 1999 Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor κBα within specific cellular populations of the rat brain. J Neurochem 73:309-321
16. Thibeault I, Laflamme N, Rivest S 2001 Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines. J Comp Neurol 434:461-477
17. Vane JR 1971 Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 231:232-235
18. Tegeder I, Pfeilschifter J, Geisslinger G 2001 Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J 15:2057-2072
19. Rivest S 1999 What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies. Mol Psychiatry 4:500-507
20. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M 1995 Immuno-suppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286-290
21. Ray A, Prefontaine KE 1994 Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA 91:752-756
22. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin Jr AS 1995 Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 15:943-953
23. Nissen RM, Yamamoto KR 2000 The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev 14:2314-2329
24. Paik JH, Ju JH, Lee JY, Boudreau MD, Hwang DH 2000 Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. J Biol Chem 275:28173-28179