Receptor binding and drug modulation in anxiety

European Neuropsychopharmacology

Volumn 12, Issue 6, 2002, Pages 567-574

  Malizia, Andrea L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Anxiety; Drug modulation; Receptor binding

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CARBAMAZEPINE; CARBON 11; CORTICOSTEROID; FLUMAZENIL; IOMAZENIL; MIDAZOLAM; RECEPTOR SUBUNIT; SEROTONIN UPTAKE INHIBITOR;

ANXIETY DISORDER; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN METABOLISM; BRAIN REGION; DRUG BINDING SITE; DRUG EFFECT; EPILEPSY; HUMAN; LIGAND BINDING; NEUROCHEMISTRY; NEUROTRANSMISSION; NONHUMAN; PANIC; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DENSITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRESS;

ANIMALS; ANXIETY; ANXIETY DISORDERS; BINDING, COMPETITIVE; BRAIN; HUMANS; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0036893559     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(02)00105-0     Document Type: Article

References (46)

1. Abadie P., Boulenger J.P., Benali K., Barre L., Zarifian E., Baron J.C. Relationships between trait and state anxiety and the central benzodiazepine receptor: a PET study. Eur. J. Neurosci. 11:1999;1470-1478.
2. Adamec R. Does long term potentiation in periacqueductal gray (PAG) mediate lasting changes in rodent anxiety-like behavior (ALB) produced by predator stress? Effects of low frequency stimulation (LFS) of PAG on place preference and changes in ALB produced by predator stress. Behav. Brain Res. 120:2001;111-135.
3. Brandt C.A., Meller J., Keweloh L., Hoschel K., Staedt J., Munz D., Stoppe G. Increased benzodiazepine receptor density in the prefrontal cortex in patients with panic disorder. J. Neural Trans. 105:(10-12):1998;1325-1333.
4. Bremner J.D., Innis R.B., White T., Fujita M., Silbersweig D., Goddard A.W., Staib L., Stern E., Cappiello A., Woods S., Baldwin R., Charney D.S. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biol. Psychiatry. 47:(2):2000;96-106.
5. Bremner J.D., Innis R.B., Southwick S.M., Staib L., Zoghbi S., Charney D.S. Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. Am. J. Psychiatry. 157:(7):2000;1120-1126.
6. Buchsbaum M.S., Wu J., Haier R., Hazlett E., Ball R., Katz M., Sokolski K., Lagunas-Solar M., Langer D. Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder. Life Sci. 40:(25):1987;2393-2400.
7. Corbett R., Fielding S., Cornfeldt M., Dunn R.W. GABAmimetic agents display anxiolytic like effects in the social interaction and elevated plus maze procedures. Psychopharmacology (Berl.). 104:1991;312-316.
8. A-receptor clustering results in enhanced anxiety and a bias for threat cues. Nature Neurosci. 2:1999;833-839.
9. Dantendorfer K., Prayer D., Kramer J., Amering M., Baischer W., Berger P., Schoder M., Steinberger K., Windhaber J., Imhof H., Katschnig H. High frequency of EEG and MRI brain abnormalities in panic disorder. Psychiatry Res. 68:(1):1996;41-53.
10. Dorow R., Horowski R., Paschelke G., Amin M. Severe anxiety induced by FG 7142, a beta carboline ligand for benzodiazepine receptors. Lancet. 2:(8341):1983;98-99.
11. Drugan R.C., Maier S.F., Skolnick P., Paul S.M., Crawley J.N. An anxiogenic benzodiazepine receptor ligand induces learned helplessness. Eur. J. Pharmacol. 113:1985;453-457.
12. File S.E., Lister R.G. Do the reductions in social interaction produced by picrotoxin and pentylenetetrazole indicate anxiogenic actions? Neuropharmacology. 23:1984;793-796.
13. Gulinello M., Gong Q.H., Li X., Smith S.S. Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res. 910:(1-2):2001;55-66.
14. Gunn R.N., Gunn S.R., Cunningham V.J. Positron emission tomography compartmental models. J. Cereb. Blood Flow Metab. 21:(6):2001;635-652.
15. Hoehn Saric R. Effects of THIP on chronic anxiety. Psychopharmacology (Berl.). 80:1983;338-341.
16. 3H]Ro 15 1788 in mice by acute stress: possible changes in in vivo binding availability of brain benzodiazepine receptor. Int. J. Nucl. Med. Biol. 12:1985;369-374.
17. Kaschka W., Feistel H., Ebert D. Reduced benzodiazepine receptor binding in panic disorders measured by iomazenil SPECT. J. Psychiatr. Res. 29:1995;423-427.
18. Kaufman J., Plotsky P.M., Nemeroff C.B., Charney D.S. Effects of early adverse experiences on brain structure and function: clinical implications. Biol. Psychiatry. 48:(8):2000;778-790.
19. Kuikka J.T., Pitkanen A., Lepola U., Partanen K., Vainio P., Bergstrom K.A., Wieler H.J., Kaiser K.P., Mittelbach L., Koponen H. Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with panic disorder. Nucl. Med. Commun. 16:1995;273-280.
20. Low K., Crestani F., Keist R., Benke D., Brunig I., Benson J.A., Fritschy J.M., Rulicke T., Bluethmann H., Mohler H., Rudolph U. Molecular and neuronal substrate for the selective attenuation of anxiety. Science. 290:(5489):2000;131-134.
21. Malizia A.L., 2001. Positron Emitting Ligands in the Study of the Clinical Psychopharmacology of Anxiety and Anxiety Disorders. MD thesis, University of Bristol.
22. Malizia A.L., Cunningham V.J., Bell C.J., Liddle P.F., Jones T., Nutt D.J. Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Arch. Gen. Psychiatry. 55:(8):1998;715-720.
23. Malizia A.L., Wilson S.J., Nutt D.J., Grasby P.M. Brain networks in conditioned anticipatory anxiety in normal volunteers. J. Psychopharmacol. 10:(3):1996;A42.
24. Nutt D.J., Glue P., Lawson C., Wilson S. Flumazenil provocation of panic attacks. Arch. Gen. Psychiatry. 47:1990;917-925.
25. Nutt D.J., Malizia A.L. New insights into the role of the GABA(A)-benzodiazepine receptor in psychiatric disorder. Br. J. Psychiatry. 179:(5):2001;390-396.
26. Orchinik M., Carroll S.S., Li Y.H., McEwen B.S., Weiland N.G. Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone. J. Cereb. Blood Flow Metab. 21:2001;330-339.
27. Onishi Y., Yonekura Y., Tanaka F., Nishizawa S., Ozakawa H., Ishizu K., Fujita T., Konishi J., Mukai T. Delayed image of iodine-123 iomazenil as a relative map of benzodiazepine receptor binding: the optimal scan time. Eur. J. Nucl. Med. 23:(11):1996;1491-1497.
28. Ploghaus A., Tracey I., Gati J.S., Clare S., Menon R.S., Matthews P.M., Rawlins J.N. Dissociating pain from its anticipation in the human brain. Science. 284:1999;1979-1981.
29. A receptor subunit mRNA levels are differentially influenced by chronic FG 7142 and diazepam exposure. Eur. J. Pharmacol. 226:1992;21-28.
30. Rago L., Kiivet R.A., Harro J., Pold M. Behavioral differences in an elevated plus maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex. Naunyn Schmiedeberg's Arch Pharmacol. 337:1988;675-678.
31. Rodin E.A., Calhoun H.D. Metrazol tolerance in a 'normal' volunteer population. A ten year follow up report. J. Nerv. Ment. Dis. 150:1970;438-443.
32. Roy Byrne P.P., Cowley D.S., Greenblatt D.J., Shader R.I., Hommer D. Reduced benzodiazepine sensitivity in panic disorder. Arch. Gen. Psychol. 47:1990;259-272.
33. Roy Byrne P.P., Lewis N., Villacres E., Diem H., Greenblatt D.J., Shader R.I., Veith R. Preliminary evidence of benzodiazepine subsensitivity in panic disorder. Arch. Gen. Psychiatry. 46:1989;165-169.
34. 11C]WAY 100635. Neuroimage. 11:(5):2000;S189.
35. 11C]WAY-100635: effects of depression and antidepressant treatment. Arch. Gen. Psychiatry. 57:(2):2000;174-180.
36. Schlegel S., Steinert H., Bockisch A., Hahn K., Schloesser R., Benkert O. Decreased benzodiazepine receptor binding in panic disorder measured by Iomazenil SPECT. A preliminary report. Eur. Arch. Psychiatry Clin. Neurosci. 244:1994;49-51.
37. Sibille E., Pavlides C., Benke D., Toth M. Genetic inactivation of the serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety. J. Neurosci. 20:(8):2000;2758-2765.
38. Strohle A., Romeo E., di Michele F., Pasini A., Yassouridis A., Holsboer F., Rupprecht R. GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment. Am. J. Psychiatry. 59:(1):2002;145-147.
39. Tiihonen J., Kuikka J., Rasanen P., Lepola U., Koponen H., Liuska A., Lehmusvaara A., Vainio P., Kononen M., Bergstrom K., Yu M., Kinnunen I., Akerman K., Karhu J. Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis. Mol. Psychiatry. 2:(6):1997;463-471.
40. 123I-iomazenil SPECT. Radiat. Med. 15:(3):1997;163-169.
41. Vythilingam M., Anderson E.R., Goddard A., Woods S.W., Staib L.H., Charney D.S., Bremner J.D. Temporal lobe volume in panic disorder - a quantitative magnetic resonance imaging study. Psychiatry Res. 99:(2):2000;75-82.
42. Walker D.L., Davis M. The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction. Pharmacol. Biochem. Behav. 71:2002;379-392.
43. A benzodiazepine receptors in the mouse. Brain Res. 519:1990;347-350.
44. Weizman R., Weizman A., Kook K.A., Vocci F., Deutsch S.I., Paul S.M. Repeated swim stress alters brain benzodiazepine receptors measured in vivo. J. Pharmacol. Exp. Ther. 249:1989;701-707.
45. Wu J.C., Buchsbaum M.S., Hershey T.G., Hazlett E., Sicotte N., Johnson J.C. PET in generalized anxiety disorder. Biol. Psychiatry. 29:(12):1991;1181-1199.
46. Yu R., Follesa P., Ticku M.K. Down-regulation of the GABA receptor subunits mRNA levels in mammalian cultured cortical neurons following chronic neurosteroid treatment. Mol. Brain Res. 41:(1-2):1996;163-168.