Absence of detectable HIV-1 provirus DNA after early highly active antiretroviral therapy in children infected by vertical transmission [2]

Journal of Acquired Immune Deficiency Syndromes

Volumn 31, Issue 4, 2002, Pages 450-452

  Muñoz Almagro, Carmen ^a   Fortuny, Claudia ^a   Juncosa, Teresa ^a   Garcia Fructuoso, Maria T ^a   Gonzalez Cuevas, A ^a   Latorre, C ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; NELFINAVIR; NEVIRAPINE; STAVUDINE; VIRUS DNA;

ANTIBODY RESPONSE; CASE REPORT; DEVICE; DNA DETERMINATION; DRUG EFFECT; DRUG EFFICACY; EARLY DIAGNOSIS; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; LETTER; OUTCOMES RESEARCH; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPAIN; VERTICAL TRANSMISSION; VIRUS LOAD; VIRUS REPLICATION;

EID: 0036892037     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-200212010-00013     Document Type: Letter

References (8)

1. Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999;340:1605-13.
2. Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type-1 with zidovudine treatment. N Engl J Med 1994;331:1173-80.
3. Perelson AS, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997;387:188-91.
4. Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD4+T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 1999; 5:512-7.
5. Dornadula G, Nunnari G, Vanella M, et al. Human immunodeficiency virus type 1-infected persons with residual disease and virus reservoirs on suppressive highly active antiretroviral therapy can be stratified into relevant virologic and immunologic subgroups. J Infect Dis 2001;183:1682-7.
6. Furtado MR, Kingsley L, Wolinsky SM. Changes in the viral mRNA expression pattern correlate with a rapid rate of CD4+T-cell number decline in human immunodeficiency virus type 1-infected individuals. J Virol 1995;69:2092-100.
7. Stellbrink HJ, Van Lunzen J, Hufert FT, et al. Asymptomatic HIV infection is characterized by rapid turnover of HIV RNA in plasma and lymph nodes but not of latently infected lymph-node Cd4+T cells. AIDS 1997;11:1103-10.
8. Luzuriaga K, McManus M, Catalina M, et al., for the PACTG356. Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: Control of viral replication and absence of persistent HIV-1 specific immune responses. J Virol 2000;74: 6984-91.