NF-κB regulates the expression of the human complement receptor 2 gene

Journal of Immunology

Volumn 169, Issue 11, 2002, Pages 6236-6243

  Tolnay, Mate ^a,b   Vereshchagina, Lyudmila A ^a   Tsokos, George C ^a,b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C2 RECEPTOR; COMPLEMENT COMPONENT C3D RECEPTOR; COMPLEMENT RECEPTOR; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; RIBONUCLEOPROTEIN; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG; DNA; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL SURFACE; CHROMATIN; CONTROLLED STUDY; FLOW CYTOMETRY; GENE DELETION; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REGULATORY MECHANISM; BINDING SITE; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION;

B-LYMPHOCYTES; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA; GENE EXPRESSION REGULATION; HUMANS; LIPOPOLYSACCHARIDES; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROMOTER REGIONS (GENETICS); RECEPTORS, COMPLEMENT 3D; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 0036884941     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.11.6236     Document Type: Article

References (42)

1. Aubry, J. P., S. Pochon, P. Graber, K. U. Jansen, and J. Y. Bonnefoy. 1992. CD21 is a ligand for CD23 and regulates IgE production. Nature 358:505.
2. Delcayre, A. X., F. Salas, S. Mathur, K. Kovats, M. Lotz, and W. Lernhardt. 1991. Epstein-Barr virus/complement C3d receptor is an interferon α receptor. EMBO J. 10:919.
3. Fingeroth, J. D., J. J. Weis, T. F. Tedder, J. L. Strominger, P. A. Biro, and D. T. Fearon. 1984. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc. Natl. Acad. Sci. USA 81:4510.
4. Tanner, J., J. Weis, D. Fearon, Y. Whang, and E. Kieff. 1987. Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis. Cell 50:203.
5. Carroll, M. C., E. M. Alicot, P. J. Katzman, L. B. Klickstein, J. A. Smith, and D. T. Fearon. 1988. Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1. J. Exp. Med. 167:1271.
6. Fischer, E., C. Delibrias, and M. D. Kazatchkine. 1991. Expression of CR2 (the C3dg/EBV receptor, CD21) on normal human peripheral blood T lymphocytes. J. Immunol. 146:865.
7. Tsoukas, C. D., and J. D. Lambris. 1988. Expression of CR2/EBV receptors on human thymocytes detected by monoclonal antibodies. Eur. J. Immunol. 18:1299.
8. Young, L. S., J. W. Sixbey, D. Clark, and A. B. Rickinson. 1986. Epstein-Barr virus receptors on human pharyngeal epithelia. Lancet 1:240.
9. Tedder, T. F., L. T. Clement, and M. D. Cooper. 1984. Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. J. Immunol. 133:678.
10. Fearon, D. T., and M. C. Carroll. 2000. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu. Rev. Immunol. 18:393.
11. Dempsey, P. W., M. E. D. Allison, S. Akkaraju, C. C. Goodnow, and D. T. Fearon. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271:348.
12. Boyd, A. W., K. C. Anderson, A. S. Freedman, D. C. Fisher, B. Slaughenhoupt, S. F. Schlossman, and L. M. Nadler. 1985. Studies of in vitro activation and differentiation of human B lymphocytes. I. Phenotypic and functional characterization of the B cell population responding to anti-Ig antibody. J. Immunol. 134:1516.
13. Griffioen, A. W., E. A. Toebes, B. J. Zegers, and G. T. Rijkers. 1992. Role of CR2 in the human adult and neonatal in vitro antibody response to type 4 pneumococcal polysaccharide. Cell. Immunol. 143:11.
14. Timens, W., A. Boes, and S. Poppema. 1989. Human marginal zone B cells are not an activated B cell subset: strong expression of CD21 as a putative mediator for rapid B cell activation. Eur. J. Immunol. 19:2163.
15. Takahashi, K., Y. Kozono, T. J. Waldschmidt, D. Berthiaume, R. J. Quigg, A. Baron, and V. M. Holers. 1997. Mouse complement receptor type 1 (CR1; CD35) and type 2 (CR2; CD21) expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice. J. Immunol. 159:1557.
16. Vereshchagina, L. A., M. Tolnay, and G. C. Tsokos. 2001. Multiple transcription factors regulate the inducible expression of the human complement receptor 2 promoter. J. Immunol. 166:6156.
17. Tolnay, M., J. D. Lambris, and G. C. Tsokos. 1997. Transcriptional regulation of the complement receptor 2 gene: role of a heterogeneous nuclear ribonucleoprotein. J. Immunol. 159:5492.
18. Tolnay, M., L. A. Vereshchagina, and G. C. Tsokos. 1999. Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein. Biochem. J. 338:417.
19. Tolnay, M., Y. T. Juang, and G. C. Tsokos. 2002. Protein kinase A enhances, whereas glycogen synthase kinase-3β inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion. Biochem. J. 363:127.
20. Hu, H., B. K. Martin, J. J. Weis, and J. H. Weis. 1997. Expression of the murine CD21 gene is regulated by promoter and intronic sequences. J. Immunol. 158:4758.
21. Makar, K. W., C. T. Pham, M. H. Dehoff, S. M. O'Connor, S. M. Jacobi, and V. M. Holers. 1998. An intronic silencer regulates B lymphocyte cell- and stage-specific expression of the human complement receptor type 2 (CR2. CD21) gene. J. Immunol. 160:1268.
22. Ulgiati, D., and V. M. Holers. 2001. CR2/CD21 proximal promoter activity is critically dependent on a cell type-specific repressor. J. Immunol. 167:6912.
23. Akira, S., and T. Kishimoto. 1997. NF-IL6 and NF-κB in cytokine gene regulation. Adv. Immunol. 65:1.
24. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225.
25. Segal, S. 1986. DEAE dextran-mediated transfection of nonadherent and adherent mammalian cells. In Basic Methods in Molecular Biology. L. G. Davis, M. D. Dibner, and J. F. Battey, eds. Elsevier, New York, pp. 290-292.
26. Garoufalis, E., I. Kwan, R. Lin, A. Mustafa, N. Pepin, A. Roulston, J. Lacoste, and J. Hiscott. 1994. Viral induction of the human β interferon promoter: modulation of transcription by NF-κB/rel proteins and interferon regulatory factors. J. Virol. 68:4707.
27. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Assays for chloramphenicol acetyltransferase. In Molecular Cloning. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, p. 16.60-16.62.
28. Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res. 17:6419.
29. Orlando, V., H. Strutt, and R. Paro. 1997. Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11:205.
30. Johnson, T. A., H. L. Wilson, and W. J. Roesler. 2001. Improvement of the chromatin immunoprecipitation (ChIP) assay by DNA fragment size fractionation. BioTechniques 31:740.
31. Caretti, G., F. Cocchiarella, C. Sidoli, J. Villard, M. Peretti, W. Reith, and R. Mantovani. 2000. Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter. J. Mol. Biol. 302:539.
32. Ulgiati, D., C. Pham, and V. M. Holers. 2002. Functional analysis of the human complement receptor 2 (CR2/CD21) promoter: characterization of basal transcriptional mechanisms. J. Immunol. 168:6279.
33. Massari, M. E., and C. Murre. 2000. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20:429.
34. Tolnay, M., L. Baranyi, and G. C. Tsokos. 2000. Heterogeneous nuclear ribonucleoprotein DO contains transactivator and DNA-binding domains. Biochem. J. 348:151.
35. Thomas, M. J., and E. Seto. 1999. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene 236:197.
36. Fujita, T., G. P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:775.
37. Lin, R., D. Gewert, and J. Hiscott. 1995. Differential transcriptional activation in vitro by NF-κB/Rel proteins. J. Biol. Chem. 270:3123.
38. Fujita, T., G. P. Nolan, H. C. Liou, M. L. Scott, and D. Baltimore. 1993. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes Dev. 7:1354.
39. Kretzschmar, M., M. Meisterernst, C. Scheidereit, G. Li, and R. G. Roeder. 1992. Transcriptional regulation of the HIV-1 promoter by NF-κB in vitro. Genes Dev. 6:761.
40. Sugano, N., W. Chen, M. L. Roberts, and N. R. Cooper. 1997. Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-κB induction. J. Exp. Med. 186:731.
41. Zhou, L. J., H. M. Smith, T. J. Waldschmidt, R. Schwarting, J. Daley, and T. F. Tedder. 1994. Tissue-specific expression of the human CD19 gene transgenic mice inhibits antigen-independent B-lymphocyte development. Mol. Cell. Biol. 14:3884.
42. Quandt, K., K. Frech, H. Karas, E. Wingender, and T. Werner. 1995. MatInd and MatInspector: new fast and versatile tools for detection of consensus rnatches in nucleotide sequence data. Nucleic Acids Res. 23:4878.