Protein kinase A enhances, whereas glycogen synthase kinase-3β inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion

Biochemical Journal

Volumn 363, Issue 1, 2002, Pages 127-136

  Tolnay, Mate ^a   Juang, Yuang Taung ^a   Tsokos, George C ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

HnRNP D; Phosphorylation; Protein kinase C; Transcription

Indexed keywords

AMINO ACIDS; ASSAYS; ENZYME INHIBITION; POLYPEPTIDES;

ISOFORMS;

PROTEINS;

CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINASE C; RIBONUCLEOPROTEIN; TATA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; DNA-BINDING PROTEINS; EXONS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; SERINE; TATA-BOX BINDING PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0036534730     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630127     Document Type: Article

References (45)

1. hnRNP proteins and the biogenesis of mRNA
2. hnRNP complexes: Composition, structure and function
3. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family
4. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein
5. Structure and genomic organization of the human AUF1 gene: Alternative pre-mRNA splicing generates four protein isoforms
6. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element
7. Heterogeneous nuclear ribonucleoprotein D0 contains transactivator and DNA-binding domains
8. Transcriptional regulation of the complement receptor 2 gene: Role of a heterogeneous nuclear ribonucleoprotein
9. Regulation of the Epstein-Barr virus C promoter by AUF1 and the cyclic AMP/protein kinase A signaling pathway
10. Identification and cloning of a novel heterogeneous nuclear ribonucleoprotein C-like protein that functions as a transcriptional activator of the hepatitis B virus enhancer II
11. Heterogeneous nuclear ribonucleoproteins as regulators of gene expression through interactions with the human thymidine kinase promoter
12. Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein
13. A specific isoform of hnRNP D interacts with DNA in the LR1 heterodimer: Canonical RNA binding motifs in a sequence-specific duplex DNA binding protein
14. AUF1 binding affinity to A + U-rich elements correlates with rapid mRNA degradation
15. Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex
16. A mechanism for translationally coupled mRNA turnover: Interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex
17. Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n
18. In vitro properties of the conserved mammalian protein hnRNP D suggest a role in telomere maintenance
19. Regulation of in vitro nucleic acid strand annealing activity of heterogeneous nuclear ribonucleoprotein protein A1 by reversible phosphorylation
20. Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes
21. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1
22. Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells
23. Assays for chloramphenicol acetyltransferase
24. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
25. PhosphoBase, a database of phosphorylation sites: Release 2.0
26. Assembly of AUF1 oligomers on U-rich RNA targets by sequential dimer association
27. Inactivation of glycogen synthase kinase-3β by phosphorylation: New kinase connections in insulin and growth-factor signalling
28. A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2
29. Role of secondary structure in discrimination between constitutive and inducible activators
30. A minimal transcription activation domain consisting of a specific array of aspartic acid and leucine residues
31. Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP DO
32. Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm
33. Local structural elements in the mostly unstructured transcriptional activation domain of human p53
34. Phosphorylation of p300 at serine 89 by protein kinase C
35. Glycogen synthase kinase-3: Functions in oncogenesis and development
36. Crystal structure of glycogen synthase kinase 3beta: Structural basis of phosphate-primed substrate specificity and autoinhibition
37. Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1
38. Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc
39. A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression
40. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
41. Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes
42. Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C
43. Inactivation of glycogen synthase kinase-3 by protein kinase C delta: Implications for regulation of tau phosphorylation
44. Control of glycogen synthase by hierarchal protein phosphorylation
45. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: A model for activator:coactivator interactions