Polymorphisms in interleukin-1 β and interleukin-1 receptor antagonist genes and malaria in Ghanaian children

Scandinavian Journal of Immunology

Volumn 56, Issue 6, 2002, Pages 619-622

  Gyan, B ^a,b   Goka, B ^c   Cvetkovic, J T ^d   Perlmann, H ^b   Lefvert, A K ^d   Akanmori, B ^a   Troye Blomberg, M ^b  

^a University of Ghana   (Ghana)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c UNIVERSITY OF GHANA   (Ghana)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; IL1RN PROTEIN, HUMAN; PROTOZOON ANTIBODY; SIALOGLYCOPROTEIN;

AGE; ALLELE; ANEMIA; ARTICLE; BRAIN MALARIA; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; EXON; GENE FREQUENCY; GENOTYPE; GHANA; HUMAN; MAJOR CLINICAL STUDY; MALARIA; PARASITEMIA; PATHOGENESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; BLOOD; CASE CONTROL STUDY; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; INFANT; MALARIA FALCIPARUM; PRESCHOOL CHILD;

ANEMIA; ANTIBODIES, PROTOZOAN; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; GENE FREQUENCY; GENOTYPE; GHANA; HUMANS; INFANT; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; PARASITEMIA; POLYMORPHISM, GENETIC; SIALOGLYCOPROTEINS;

EID: 0036884397     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2002.01161.x     Document Type: Article

References (16)

1. Jakobsen PH, McKay V, Morris-Jones SD et al. Increased concentrations of interleukin-6 and interleukin-1 receptor antagonist and decreased concentrations of beta-2-glycoprotein I in Gambian children with cerebral malaria. Infect Immun 1994;62:4374-9.
2. Kurtzhals JA, Adabayeri V, Quarm-Goka B et al. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Lancet 1998;351:1768-72.
3. Kwiatkowski D, Hill AV, Sambou I et al. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 1990;336:1201-4.
4. McGuire W, Knight JC, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D. Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. J Infect Dis 1999;179:287-90.
5. Molyneux EM, Taylor TE, Wirima JJ, Borgstein A. Tumor necrosis factor, interleukin-6, and malaria. Lancet 1991;337:1098.
6. Akanmori BD, Kurtzhals JA, Goka BQ et al. Distinct patterns of cytokine regulation in discrete clinical forms of Plasmodium falciparum malaria. Eur Cytokine Netw 2000;11:113-8.
7. Dinarello C. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095-147.
8. Steinkasserer A, Spurr NK, Cox S, Jeggo P, Sim RB. The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics 1992;13:654-7.
9. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur J Clin Invest 1992;22:396-402.
10. Tarlow JK, Blakemore AI, Lennard A et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 1993;91:403-4.
11. Bellamy R, Kwiatkowski D, Hill AV. Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. Trans R Soc Trop Med Hyg 1998;92:312-6.
12. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: A study of 131 comatose Malawian children. Q J Med 1989;71:441-59.
13. Marmur J. A procedure for the isolation of deoxyribonucleic acid from microorganisms. J Mol Biol 1961;3:208-18.
14. Bioque G, Crusius JB, Koutroubakis I et al. Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease. Clin Exp Immunol 1995;102:379-83.
15. Perlmann H, Helmby H, Hagstedt M et al. IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: Association of high IgE levels with cerebral malaria. Clin Exp Immunol 1994;97:284-92.
16. Rockett KA, Awburn MM, Rockett EJ, Clark IA. Tumor necrosis factor and interleukin-1 synergy in the context of malaria pathology. Am J Trop Med Hyg 1994;50:735-42.