5α-Reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: Suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids

Journal of Steroid Biochemistry and Molecular Biology

Volumn 82, Issue 4-5, 2002, Pages 393-400

  Pham, Hung ^a   Ziboh, Vincent A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

15S hydroxyeicosapentaenoic acid; 15S hydroxyeicosatrienoic acid; 5 Reductase; Dihydrotestosterone; Gamma linolenic acid; Testosterone

Indexed keywords

ANDROSTANOLONE; ARACHIDONATE 15 LIPOXYGENASE; GAMMA LINOLENIC ACID; HYDROXYICOSAPENTAENOIC ACID; HYDROXYICOSATRIENOIC ACID; ICOSAPENTAENOIC ACID; POLYUNSATURATED FATTY ACID; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; METABOLITE; NONHUMAN; PRECURSOR; PROSTATE ADENOCARCINOMA; RAT; TESTOSTERONE METABOLISM;

ADENOCARCINOMA; ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; CELLS, CULTURED; CHOLESTENONE 5 ALPHA-REDUCTASE; DIHYDROTESTOSTERONE; EICOSAPENTAENOIC ACID; GAMMA-LINOLENIC ACID; MALE; OXIDOREDUCTASES; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; RATS; RATS, WISTAR; TESTOSTERONE; TUMOR CELLS, CULTURED;

EID: 0036879071     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(02)00217-0     Document Type: Article

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